Compound Famotidine sustained release tablets and preparing method thereof

A technology of famotidine and sustained-release tablets, applied in the field of medicine, can solve the problems of leukopenia and increase, and achieve the effects of fast onset, good curative effect and good synergistic effect.

Inactive Publication Date: 2016-02-10
QINGDAO HAIZHIYUAN INTELLIGENT TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, headache, dizziness, constipation and diarrhea are the most common when using this drug, and the incidence rates are 4.7%, 1.3%, 1.2% and 1.7% respectively. Occasionally, rash, urticaria, leukopenia, elevated transaminase, etc.; Symptoms such as abdominal fullness, loss of appetite, increased heart rate, increased blood pressure, flushed face, and irregular menstruation limit the widespread use of famotidine

Method used

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  • Compound Famotidine sustained release tablets and preparing method thereof
  • Compound Famotidine sustained release tablets and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A compound sustained-release tablet of famotidine, the components and parts by weight of the sustained-release tablet include: 1 part of famotidine, 10 parts of Yuanhu, 12 parts of Ferulicum, 10 parts of aloe, 11 parts of Yu Liren, radish 9 parts of lotus seeds, 10 parts of hollow bubbles, 12 parts of poria cocos, 11 parts of Codonopsis pilosula, 10 parts of licorice, 14 parts of microcrystalline cellulose pellets, 2 parts of polyacrylic resin, 0.3 parts of glyceride, 0.2 parts of hypromellose, starch 5 parts, 2 parts of calcium stearate, 13 parts of sodium carbonate, 1 part of hydroxypropyl cellulose.

[0023] A preparation method for famotidine compound sustained-release tablets, the specific steps comprising:

[0024] 1) raw material preparation: prepare raw materials according to the above-mentioned components and parts by weight of a kind of famotidine compound sustained-release tablet, starch, calcium stearate, sodium carbonate are pulverized respectively and pass...

Embodiment 2

[0031] A compound sustained-release tablet of famotidine, the components and parts by weight of the sustained-release tablet include: 4 parts of famotidine, 19 parts of Yuanhu, 23 parts of ferulicum, 20 parts of aloe, 24 parts of Yu Liren, radish 18 parts of lotus seeds, 22 parts of hollow bubbles, 23 parts of poria cocos, 24 parts of Codonopsis pilosula, 18 parts of licorice, 25 parts of microcrystalline cellulose pellets, 5 parts of polyacrylic resin, 0.7 parts of glyceride, 0.5 parts of hypromellose, starch 14 parts, 7 parts of calcium stearate, 19 parts of sodium carbonate, 4 parts of hydroxypropyl cellulose.

[0032] The preparation method of above-mentioned a kind of famotidine compound sustained-release tablet is the same as embodiment 1.

Embodiment 3

[0034] A compound sustained-release tablet of famotidine, the components and parts by weight of the sustained-release tablet include: 2 parts of famotidine, 13 parts of Yuanhu, 15 parts of Ferulicum, 13 parts of aloe, 16 parts of Yu Liren, radish 12 parts of lotus seeds, 12 parts of hollow bubbles, 15 parts of poria cocos, 16 parts of Codonopsis pilosula, 13 parts of licorice, 17 parts of microcrystalline cellulose pellets, 3 parts of polyacrylic resin, 0.4 parts of glyceride, 0.3 parts of hypromellose, starch 6 parts, 3 parts of calcium stearate, 14 parts of sodium carbonate, 2 parts of hydroxypropyl cellulose.

[0035] The preparation method of above-mentioned a kind of famotidine compound sustained-release tablet is the same as embodiment 1.

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Abstract

The invention relates to compound Famotidine sustained release tablets and a preparing method thereof. The compound Famotidine sustained release tablets are prepared from, by weight, 1-4 parts of Famotidine, 10-19 parts of rhizoma corydalis, 12-23 parts of ferula asafetida, 10-20 parts of aloe, 11-24 parts of bunge cherry seeds, 9-18 parts of metaplexis fruit, 10-22 parts of rubus rosifolius, 12-23 parts of poria cocos, 11-24 parts of codonopsis pilosula, 10-18 parts of liquorice, 14-25 parts of microcrystalline cellulose pills, 2-5 parts of polyacrylic resin, 0.3-0.7 part of glyceride, 0.2-0.5 part of hydroxypropyl methylcellulose, 5-14 parts of starch, 2-7 parts of calcium stearate, 13-19 parts of sodium carbonate and 1-4 parts of hydroxypropyl cellulose. The compound Famotidine sustained release tablets can quickly relieve pains and other symptoms for patients and improve the compliance of patients.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a compound sustained-release famotidine tablet and a preparation method thereof. Background technique [0002] Esophagitis is esophagitis, which generally refers to inflammation caused by edema and congestion of the esophageal mucosa due to irritation or damage to the superficial or deep layers of the esophageal mucosa. Chemical stimuli include gastric acid, bile, spirits, strong acid, strong alkali, drugs, etc.; physical stimuli include hot food, drink, esophageal foreign body (fishbone, etc.) incarceration, long-term placement of nasogastric tube, etc. Famotidine is commonly used to treat esophagitis. It is a histamine H2 receptor antagonist. Its action strength is 30-100 times greater than cimetidine and 6-10 times greater than ranitidine. It has obvious effects on gastric acid secretion. Inhibitory effect, has a good therapeutic effect on esophagitis. However, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/886A61K36/896A61K9/36A61P1/04A61K31/426A61K47/38A61K47/32
Inventor 王芬张伟唐佳张祥
Owner QINGDAO HAIZHIYUAN INTELLIGENT TECH
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