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Application of composition to preparation of medicines for preventing and treating senile dementia

A technology for senile dementia and its composition, applied in the field of medicine, can solve the problems of not being able to meet the clinical needs of senile dementia, not being able to treat senile dementia at will, and difficult to obtain good curative effect of drugs, so as to achieve the goal of being suitable for clinical application and reducing Oxygen free radical damage, excellent effect of drug effect

Active Publication Date: 2016-02-03
GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently commonly used drugs are mainly aimed at different etiological hypotheses, and proposed alternative drug treatments, including cholinesterase inhibitors, cerebral vasodilators, calcium antagonists, drugs to prevent Aβ deposition, anti-inflammatory drugs, etc., but the elderly The onset of dementia involves multi-system and multi-target abnormalities. Drugs with a single point of action are generally difficult to achieve good curative effect, and some drugs have disadvantages such as large side effects. The treatment of senile dementia, the treatment of brain damage and other drugs can be used in the prevention and treatment of senile dementia still needs to be further studied and explored, so the existing drugs can not meet the clinical needs of the prevention and treatment of senile dementia

Method used

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  • Application of composition to preparation of medicines for preventing and treating senile dementia
  • Application of composition to preparation of medicines for preventing and treating senile dementia
  • Application of composition to preparation of medicines for preventing and treating senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The test drug of this embodiment experimental group is made up of the following components by weight:

[0025]

[0026] 1. Experimental method

[0027] 1.1 Preparation of Alzheimer's dementia rats

[0028] 105 rats were randomly divided into 7 groups, namely the normal group, the sham operation group, the model group, the positive group, and the high, middle and low dose experimental groups, with 15 rats in each group. After the rats in the model group, the positive group, and the high, middle and low dose experimental groups were anesthetized with pentobarbital sodium, the hair on the top of the head was removed, the skin was disinfected and cut open, and the injection points in the bilateral hippocampus (AP-3.5mm, ML±2.5mm, DV3.0mm) were injected with 5 μL (10 μg) of aggregated Aβ25-35; the sham operation group was injected with the same amount of normal saline; the normal group did not perform any of the above operations, and the injection was completed within 10...

Embodiment 2

[0048] The test drug of this embodiment experimental group is made up of the following components by weight:

[0049]

[0050] 1. Experimental method

[0051] 1.1 Preparation of vascular dementia rats

[0052] 105 rats were randomly divided into 7 groups, namely the normal group, the sham operation group, the model group, the positive group, and the high, middle and low dose experimental groups, with 15 rats in each group. The five groups of rats in the model group, the positive group, and the high-middle-low-dose experimental group were anesthetized with pentobarbital sodium, fixed in the supine position, and after the midline of the neck was shaved and disinfected, the midline of the neck was cut, and the bilateral common carotid arteries were separated, and both sides were ligated with double silk thread. The lateral common carotid artery was sutured; the sham operation group only freed the bilateral common carotid artery; the normal group did not perform any of the abo...

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Abstract

The invention relates to application of a composition to preparation of medicines for preventing and treating senile dementia. The composition comprises the following components: gamma-aminobutyric acid, choline chloride, oryzanol, vitamin E, vitamin B1, niacin, pseudo-ginseng powder, a salvia miltiorrhiza extract, an acanthopanax extract, a polygonum multiflorum extract and an acorus gramineus extract. The composition can obviously improve alzheimer type dementia, vascular dementia model rat working dysmnesia and spatial discrimination studying dysmnesia and the like, can relieve oxygen radical damage, and has an excellent curative effect of preventing and treating senile dementia.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a new application of a pharmaceutical composition in the preparation of medicines for preventing and treating senile dementia. Background technique [0002] Alzheimer's disease is a neurodegenerative disease with memory and cognitive impairment as the main clinical manifestations. It can be divided into Alzheimer's dementia (AD), vascular dementia (VaD) and mixed dementia ( Mix D). In addition to deteriorating cognition and memory functions, senile dementia is accompanied by a progressive decline in the ability of daily living, often accompanied by various neuropsychiatric symptoms and behavioral disorders. The prevalence rate of senile dementia in my country is about 2% to 5%. With the growth of age, the prevalence rate gradually increases, and the elderly can reach 10% to 20%. The average survival period of senile dementia patients is only 5.9 years, and its mortality rate is second o...

Claims

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Application Information

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IPC IPC(8): A61K36/888A61P25/28A61K31/197A61K31/14A61K31/575A61K31/355A61K31/51A61K31/455
Inventor 朱少璇郑丽真许春江王健松王玮陈晓燕
Owner GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY
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