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A kind of ferrohematoporphyrin material, preparation and application of encapsulating gold nanoparticles

A gold nanoparticle and nanoparticle technology, applied in the field of biological analysis, can solve the problems of low catalytic activity and lack of bionic environment, and achieve the effects of good biocompatibility, improved catalytic efficiency, and promotion of electron transfer.

Inactive Publication Date: 2018-05-01
NANJING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hemin has extremely high catalytic performance for nitrogen, oxygen, nitric oxide, carbon dioxide and peroxide, but its catalytic activity is much lower than that of natural enzymes due to the lack of a suitable bionic environment.

Method used

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  • A kind of ferrohematoporphyrin material, preparation and application of encapsulating gold nanoparticles
  • A kind of ferrohematoporphyrin material, preparation and application of encapsulating gold nanoparticles
  • A kind of ferrohematoporphyrin material, preparation and application of encapsulating gold nanoparticles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Preparation of polyethyleneimine-wrapped gold nanoparticles (PEI-AuNPs): at room temperature, polyethyleneimine was added to a 1 mmol / L chloroauric acid solution, and the mixed solution was stirred and heated to 80°C. Keep for a certain period of time until the solution turns light ruby ​​red, then stop heating and stirring, and cool at room temperature. Wherein, the volume ratio of polyethyleneimine and chloroauric acid is 1:30, the stirring rate is 200 rpm, and the holding time is 5 min.

Embodiment 2

[0027] Example 2: Preparation of polyethyleneimine-wrapped gold nanoparticle material (PEI-AuNPs): at room temperature, polyethyleneimine was added to a 1 mmol / L chloroauric acid solution, and the mixed solution was stirred and heated to 80°C, Keep for a certain period of time until the solution turns light ruby ​​red, then stop heating and stirring, and cool at room temperature. Wherein, the volume ratio of polyethyleneimine and chloroauric acid is 1:5, the stirring rate is 700 rpm, and the retention time is 30 min.

Embodiment 3

[0028] Example 3: Preparation of polyethyleneimine-wrapped gold nanoparticles (PEI-AuNPs): at room temperature, polyethyleneimine was added to a 1 mmol / L chloroauric acid solution, and the mixed solution was stirred and heated to 80°C. Keep for a certain period of time until the solution turns light ruby ​​red, then stop heating and stirring, and cool at room temperature. Wherein, the volume ratio of polyethyleneimine and chloroauric acid is 1:10, the stirring rate is 400 rpm, and the holding time is 20 min.

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Abstract

The invention discloses a novel material containing biomimetic enzymes. The material uses PEI to synthesize gold nanoparticles. PEI is a positively charged polymer rich in imine groups and amine groups and has good water solubility. It can be combined with chloroauric acid Coordination of gold ions in the PEI, using the reduction of PEI branched chain amino groups to prepare gold nanoparticles with uniform particle size and stability. In addition, because the PEI molecule contains amino groups, it is easy to form an amide bond with Hemin, so that the Hemin molecule is connected to the PEI containing gold nanoparticles, and through centrifugation and separation and purification, a hematoporphyrin biomimetic material wrapped with gold nanoparticles is obtained. . This new type of material not only has the high catalytic performance of biomimetic enzymes, it can be used as an electrochemical probe to detect the content of pollutants in water, such as hydrogen peroxide, catechol, etc. On the other hand, due to the porous structure of the material itself, it can Dye molecules, such as methyl orange, rhodamine, etc., are adsorbed to protect the ecological environment.

Description

technical field [0001] The invention belongs to the technical field of biological analysis, and specifically relates to a bionic material, its preparation and its application, in particular to a material, its preparation and its application for highly sensitive detection of hydrogen peroxide. Background technique [0002] The research and development of nanotechnology has provided a wider application space for nanomaterials, and currently the main focus is on the immobilization of biomolecules by nanomaterials. Among numerous nanomaterials, gold nanoparticles have become a promising candidate in optics, electronics, catalysis, and biomedicine due to their good stability, small size effect, surface effect, optical effect, and special bioaffinity effect. Research and application hotspots. In terms of electrochemistry, the sensor prepared by using gold nanoparticles has strong selectivity, good stability and simple operation method. Gold nanoparticles have a large specific su...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/327
Inventor 孔金明于雪花胡伟文顾淑梅张学记
Owner NANJING UNIV OF SCI & TECH
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