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Lanthanide-series compound and preparation method and application thereof

A technology of lanthanide compounds and compounds, which is applied in the field of ultra-micro analysis in vitro, can solve the problems of being vulnerable to temperature, sensitivity and precision, and achieve the effect of strong stability

Active Publication Date: 2016-01-06
SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But in general, the activity of the enzyme used in this method is easily affected by temperature, pH and the concentration of various ions in the solution, which makes the sensitivity and precision of this method inferior to radioimmunoassay in most cases.

Method used

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  • Lanthanide-series compound and preparation method and application thereof
  • Lanthanide-series compound and preparation method and application thereof
  • Lanthanide-series compound and preparation method and application thereof

Examples

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Embodiment 1

[0058] A preparation method of lanthanide compounds, the method comprising the following steps

[0059] (1) Synthesis of Compound A2:

[0060] Mix 11.17g of compound A1, 15.77g of pyridinium salt, 22.35g of ammonium acetate and 200mL of anhydrous methanol, reflux for 12h, filter with suction, wash the solid with anhydrous methanol and dry to obtain a white product, which can be obtained by drying Compound A2, wherein compound A1 is (1E,5E)-1,6-bis(2-furyl)-1,5-hexadiene-3,4-dione;

[0061] (2) Synthesis of Compound A3:

[0062] Add 1 mol of compound A2 and 2 mol of potassium permanganate into 180 mL of tert-butanol solution in turn, stir and reflux for 7 hours, cool to room temperature, adjust the pH value to 2 with hydrochloric acid, and wash the precipitated solid with ice methanol after suction filtration. Obtain a brown or yellow product and dry it to obtain compound A3;

[0063] (3) Synthesis of Compound A4:

[0064] Dissolve 0.3514g of compound A3 in 20mL of methanol...

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Abstract

The invention provides a lanthanide-series compound and a preparation method and an application thereof; the lanthanide-series compound has the chemical structural formula described in the description. The lanthanide-series compound has no inversion center, is beneficial for the compound to generate higher-brightness fluorescence, and enables a strongest emission peak to be used in a fluorescence analysis peak of time-resolved fluorescence immunoassay; and at the same time, the compound has relatively strong stability, and still can be used for marking and testing after being placed for a certain time.

Description

technical field [0001] The invention belongs to the technical field of in vitro ultra-trace analysis, and in particular relates to a lanthanide compound and its preparation method and application. Background technique [0002] The marker immunoassay method created in the early 1960s is a comprehensive product that combines high-tech marker and tracer technology with medical immunology. That is, the method and technology that combines the labeling technology with special advantages and the unique specific reaction in immunology. This technique has a high degree of specificity, and also has an extremely good microanalysis effect. Now this technology has been widely used in the research of important aspects such as disease diagnosis and curative effect observation. American chemists discovered an analytical technique that can measure ultra-trace substances in the process of studying antibodies. This technique is called radioimmunoassay (radioimmunoassay, RIA), which uses spec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F5/00C09K11/06G01N21/64
Inventor 彭义杰唐玉国武晓东
Owner SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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