Non-steroidal anti-inflammatory drug ultra-fine powder and preparation method thereof

Abstract

The invention relates to non-steroidal anti-inflammatory drug ultra-fine powder and a preparation method thereof. A non-steroidal anti-inflammatory drug has the functions of resisting inflammations and rheumatism, relieving pain, bringing down a fever and resisting blood coagulation and is widely used for alleviating osteoarthritis, rheumatoid arthritis, various fevers and various painful symptoms in clinic. The method for preparing the non-steroidal anti-inflammatory drug ultra-fine powder comprises the steps that non-steroidal anti-inflammatory drug crystals are rapidly obtained by exerting ultrasonic waves with the frequency ranging from 10 kHz to 500 kHz, the power ranging from 1 mW to 5000 W and the sound intensity ranging from 0.1 mW / cm<2> to 500 w / cm<2> into a homogeneous solution containing the non-steroidal anti-inflammatory drug, and then the non-steroidal anti-inflammatory drug ultra-fine powder is directly obtained after normal operations such as solid collection, washing and drying are conducted. The non-steroidal anti-inflammatory drug ultra-fine powder is free of substrate materials and has the advantages that the drug-loading rate is high, the dissolution velocity is high, higher bioavailability is easy to achieve, and the stability and the safety are achieved, so that the requirements for improving the bioavailability of the drug, decreasing the drug dosage and reducing adverse reactions are met, and a wide application prospect in clinic is achieved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an ultrafine powder of non-steroidal anti-inflammatory drugs and a preparation method thereof. Background technique [0002] Non-steroidal anti-inflammatory drugs (NSAIDs) are called non-steroidal anti-inflammatory drugs (NSAIDs) because of their chemical structure and anti-inflammatory mechanism are different from glucocorticoid steroidal anti-inflammatory drugs (SAIDS); pain effect. In addition to the commonly used oral and injection dosage forms, it is also widely used in topical medicine such as eyes. At present, NSAIDs are one of the most used drugs in the world, and about 30 million people in the world use them every day. [0003] Aspirin is slightly soluble in water and easily soluble in ethanol. It is one of the three classic drugs in the history of medicine, and is the most widely used antipyretic and analgesic anti-inflammatory drug in clinical practice. If the dos...

AI Technical Summary

Problems solved by technology

However, due to the high requirements of supercritical technology on equipment and the state of supercritical fluid is greatly affected by temperature and pressure, it is difficult to maintain the state, and the research on related application equipment still needs to be further strengthened

[0028] Anti-solvent recrystallization, solvent diffusion, solvent evaporation, reaction precipitation and other methods, due to uncontrollable crystal growth, resulting in large product size differences, and generally accompanied by high-speed stirring or high-speed centrifugation or high-pressure homogenization, while spray drying and freezing Drying is used as a drying method to collect dry particles and usually needs to be combined with other methods; the above methods are not easy to configure industrial production equipment, the operation risk factor is high, and the cost is high

[0029] The various defects of the above-mentioned ultrafine powder preparation method are the main factors that lead to the extremely small number and types of drugs that are currently listed as non-steroidal anti-inflammatory drugs in the form of ultrafine powder.

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