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Wild guava oral administration tablets capable of reducing blood sugar and resisting oxidation and preparation method of wild guava oral administration tablets

A technology for oxidizing oral tablets and wild guava, which is applied in the field of tablets and its preparation, can solve the problems of insufficient development and utilization of wild guava fruit, and achieve the effects of delaying tissue and organ damage, accelerating metabolism, and slightly sweet taste

Inactive Publication Date: 2015-12-23
YUNNAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problem of insufficient development and utilization of the existing wild guava fruit, the present invention provides a wild guava oral anti-diabetic tablet and a preparation method thereof

Method used

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  • Wild guava oral administration tablets capable of reducing blood sugar and resisting oxidation and preparation method of wild guava oral administration tablets
  • Wild guava oral administration tablets capable of reducing blood sugar and resisting oxidation and preparation method of wild guava oral administration tablets

Examples

Experimental program
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Effect test

Embodiment 1

[0031] In this example, wild guavas produced in Huaping County, Lijiang City, Yunnan Province were used as raw materials, and oral tablets were prepared according to the following steps:

[0032] Ripe wild guava fruit is cut into fruit pieces whose length and thickness are 4-5 mm, and dried at 50° C. and 0.07 MPa vacuum to obtain dried fruit pieces. Tween-80 was weighed and prepared into an aqueous solution with a mass percent concentration of 0.1%, and its pH value was adjusted to 5 with hydrochloric acid.

[0033]Weigh the dried fruit slices, add 8 times the weight of the above-mentioned aqueous solution containing Tween-80 with a pH value of 5, use 28kH, 300W ultrasonic temperature control to treat at 35°C for 60 minutes, collect the extract, and then repeat the above ultrasonic treatment operation twice , combined the extracts, and concentrated the extracts at 50°C and 0.07MPa vacuum to a mass equivalent to 0.8g / mL of dried fruit slices to obtain wild guava fruit extracts....

Embodiment 2

[0038] In this embodiment, wild guava produced in Miyi County, Panzhihua City, Sichuan Province is used as raw material, and oral tablets are prepared according to the following steps:

[0039] Ripe wild guava fruit is cut into fruit pieces whose length and thickness are 4-5 mm, and dried at 50° C. and 0.07 MPa vacuum to obtain dried fruit pieces. Tween-80 was weighed and prepared into an aqueous solution with a mass percent concentration of 0.05%, and its pH value was adjusted to 3 with hydrochloric acid.

[0040] Weigh the dried fruit slices, add 8 times the weight of the above-mentioned aqueous solution containing Tween-80 with a pH value of 3, use 28kH, 300W ultrasonic temperature control to treat at 35°C for 60 minutes, collect the extract, and then repeat the above ultrasonic treatment operation twice , combined the extracts, and concentrated the extracts at 50°C and 0.07MPa vacuum to a mass equivalent to 1.4g / mL of dried fruit slices to obtain wild guava fruit extracts....

Embodiment 3

[0045] In this embodiment, wild guava produced in Yongsheng County, Lijiang City, Yunnan Province is used as raw material, and oral tablets are prepared according to the following steps:

[0046] Ripe wild guava fruit is cut into fruit pieces whose length and thickness are 4-5 mm, and dried at 50° C. and 0.07 MPa vacuum to obtain dried fruit pieces. Sodium lauryl sulfate was weighed to prepare an aqueous solution with a concentration of 0.05% by mass, and its pH value was adjusted to 4 with hydrochloric acid.

[0047] Weigh the dried fruit slices, add 8 times the weight of the above-mentioned aqueous solution containing sodium lauryl sulfate with a pH value of 4, use 28kH, 300W ultrasonic temperature control to treat at 35°C for 60 minutes, collect the extract, and then repeat the above ultrasonic treatment operation Twice, the extracts were combined, and the extracts were concentrated at 50°C and 0.07 MPa vacuum to a mass equivalent to 1.0 g / mL of dried fruit slices to obtain...

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Abstract

The invention discloses wild guava oral administration tablets capable of reducing blood sugar and resisting oxidation and a preparation method of the wild guava oral administration tablets. Each wild guava oral administration tablet comprises 50 parts of a wild guava extract, 10-20 parts of a filler, 8-15 parts of an adhesive, 2-5 parts of a disintegrant and 0.5-2 parts of a lubricant. After intragastric administration is performed on a mouse for 30 days through the oral administration tablets, the fasting blood sugar value of the mouse with diabetes induced by alloxan can restore to a value under a normal value of 7mmol / L, and besides, the activity of superoxide dismutase in mouse serum is improved. The preparation method comprises the following steps: using an acidic aqueous solution containing surface active substances for extracting wild guavas in a short time under the assistance of ultrasonic waves under lower temperature conditions so as to obtain active substances capable of reducing blood sugar and resisting oxidation, and then controlling reasonable parameters to prepare the oral administration tablet. The tablets contain rich protein and polysaccharide, so that a hypoglycemic reaction can be avoided. The tablets are small in size, small in dosage, and natural, safe and efficient, and can solve the problem that a dried guava chankings tea is low in utilization rate and poor in efficacy. The oral administration tablets have multiple efficacies of reducing the blood sugar, resisting oxidation, nutritional support and the like, and can provide a new selection for auxiliary treatment and nutritional health care of patients with diabetes.

Description

technical field [0001] The invention belongs to the technical field of tablets and their preparation, in particular to a wild guava fruit hypoglycemic and anti-oxidant oral tablet and a preparation method thereof. Background technique [0002] With the improvement of people's living standards, the incidence of diabetes is increasing year by year. As we all know, Western medicine has many adverse reactions in the treatment of diabetes, and the patient’s financial burden is heavy, while the use of Chinese herbal medicine in the treatment of diabetes has the characteristics of mild and long-lasting hypoglycemia, with few side effects, and can delay complications through the antioxidant effect of natural phytochemical components. There is an increasing demand for plant ingredients to prevent and assist in the treatment of diabetes. [0003] Wild guava belongs to the genus Guava of Myrtaceae. It is a folk Chinese herbal medicine. It is mainly distributed in Yunnan, Sichuan, Guiz...

Claims

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Application Information

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IPC IPC(8): A23L1/30A23P1/02A61K36/61A61K9/20A61P3/10A61P39/06
CPCA23V2002/00A61K36/00A23V2200/30A23V2200/328
Inventor 龚英陈继平常杰鲜
Owner YUNNAN NORMAL UNIV
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