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Composition for treating dermatoses caused by bacteria, fungi, viruses or parasites

A parasite and composition technology, applied in the field of skin disease composition, can solve problems such as infectivity, impact on quality of life, and sensitivity of diseased parts

Active Publication Date: 2015-12-09
WUXI HONGRUI BIOMEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Some of these skin diseases seriously affect the appearance, and some diseased parts are sensitive and contagious, seriously affecting the quality of life, and even causing long-term adverse effects. There is an urgent need to develop medical drugs that are effective in treatment, safe to use, and have a wide range of applications.
However, there is no use of ascorbyl esters of non-steroidal anti-inflammatory drugs such as gossypol, dialkyl quaternary ammonium salts and ibuprofen as effective active ingredients to formulate and develop solutions for the treatment of skin diseases caused by bacteria, fungi, viruses or parasites. Any reports of topical formulations such as pastes, creams, lotions, ointments, tinctures, and emulsions

Method used

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  • Composition for treating dermatoses caused by bacteria, fungi, viruses or parasites
  • Composition for treating dermatoses caused by bacteria, fungi, viruses or parasites
  • Composition for treating dermatoses caused by bacteria, fungi, viruses or parasites

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Dissolve 5g of Span 80 and 15g of Tween 80 in 780g of water, then add 200g of glycerin to prepare 1kg of matrix.

[0023] Add 97 g of gossypol acetate and 100 g of ibuprofen ascorbate in 800 g of the matrix, and stir while adding, so that they are evenly dispersed in the matrix. Then continue to stir, and add 3 g of didecyldimethylammonium bromide while stirring, and continue to stir for 30 minutes after the addition is completed, to obtain an ointment.

[0024] The ointment base is diluted according to the ratio of ointment: base = 10:0, 1:1, 1:9, and prepared into preparations with different drug content concentrations for testing.

Embodiment 2

[0026] Dissolve 5 g of egg yolk lecithin and 15 g of monoglyceride in 980 g of cottonseed oil to prepare 1 kg of oily base.

[0027] Add 3 g of dihexadecyldimethyl ammonium bromide, 97 g of gossypol acetate and 300 g of ketoprofen ascorbate in 600 g of the oily base, and stir while adding to make them evenly dispersed in the oily base. Continue to stir for 30min to obtain ointment.

[0028] The ointment is diluted with an oily base according to the ratio of ointment: oily base = 10:0, 1:1, 1:9, and prepared into preparations with different drug content concentrations for testing.

Embodiment 3

[0030] Add didodecyldimethylammonium bromide 3g, gossypol 300g and flurbiprofen axetil ascorbate 47g in 75% ethanol aqueous solution 650g, stir while adding, make them disperse evenly in 75% ethanol aqueous solution, Continue stirring for 30 minutes after the addition is complete, and the tincture is obtained.

[0031] The tincture was diluted with 75% ethanol aqueous solution according to the ratio of tincture:75% ethanol aqueous solution=10:0, 1:1, 1:9, and prepared into preparations with different drug content concentrations for testing.

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Abstract

The invention belongs to the technical field of pharmaceutical preparation formulae and particularly relates to a composition for treating dermatoses caused by bacteria, fungi, viruses or parasites. The composition, which is tincture, spray, cream or ointment for external use, is capable of killing various bacteria, fungi, parasites and protozoa and inhibiting various viruses, and can be used for treating various dermatoses such as dermatitis, epifolliculitis, acne, acne rosacea, non-gonococcal urethritis, condyloma acuminate, syphilis, flat wart, onychomycosis, tinea of feet and hands, tinea cruris, gonorrhea, scabies, crab lice, trichomonas parasites, chlamydial infection, herpes progenitalis, herpes zoster, measles, roseola infantum, hand-foot-mouth disease and rubella caused by the bacteria, the fungi, the viruses or the parasites. The composition which is a preparation for external use takes gossypol and double alkyl quaternary ammonium salts as main active components for sterilization, deinsectization and virus resistance and supplementally takes ascorbic acid esters of non-steroidal anti-inflammatory drugs such as ibuprofen as main active components for diminishing inflammation, easing pain and restoring and enhancing normal function of the skin, thereby being quite safe and effective.

Description

technical field [0001] The invention belongs to the technical field of formulation of pharmaceutical preparations, in particular to a composition for treating skin diseases caused by bacteria, fungi, viruses or parasites. Background technique [0002] The skin on the surface of the body is the largest organ of the human body and one of the most important. Skin consists of epidermis, dermis, and subcutaneous tissue from outside to inside. Although our skin has a strong ability to resist external stimuli and self-repair, there are still many bacteria (such as folliculitis, erysipelas and leprosy), fungi (hand and foot tinea, jock itch and onychomycosis, etc.), viruses (such as hand, foot and mouth disease) , flat warts, herpes, etc.) or parasites (such as scabies) infection caused by skin diseases seriously threaten human health. [0003] Some of these skin diseases seriously affect the appearance, and some affected parts are sensitive and contagious, seriously affecting the...

Claims

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Application Information

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IPC IPC(8): A61K31/375A61K31/404A61K31/407A61K31/436A61P31/04A61P31/10A61P31/12A61P33/00A61P17/00A61K31/11A61K31/14
Inventor 汤鲁宏杨菲菲冯玉舟徐慧芬万青华
Owner WUXI HONGRUI BIOMEDICAL TECH CO LTD
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