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Chelating adsorbent for blood purification and preparation method for chelating adsorbent

A blood purification and adsorbent technology, applied in chemical instruments and methods, blood circulation treatment, other chemical processes, etc., can solve the problems of poor blood compatibility, process production efficiency reduction, limitations, etc., achieve simple methods, improve adsorption and removal Ability, the effect of structural simplification

Active Publication Date: 2015-12-02
佛山市博新生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Among the existing adsorbents, the main functional monomers of ion exchange resins commonly used to remove heavy metals are acrylic acid, sulfonic acid benzene, etc., and their preparation methods are simple, but their compatibility with blood is poor, which limits their use.
[0005] In addition, the current adsorbent carrier is mainly microspherical particles, and the adsorption column often needs to install structures such as grids and filters to prevent the adsorbent particles from falling into the human body. Such a structure will reduce the production efficiency of the process

Method used

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  • Chelating adsorbent for blood purification and preparation method for chelating adsorbent
  • Chelating adsorbent for blood purification and preparation method for chelating adsorbent

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preparation example Construction

[0032] A preparation method for blood purification chelating adsorbent, comprising the steps of:

[0033] 1) polymer is immersed in the organic solvent solution of the monomer containing vinyl and maleic anhydride, carries out radiation treatment;

[0034] 2) remove unreacted monomer, maleic anhydride and organic solvent to obtain adsorbent;

[0035] Wherein, the vinyl-containing monomer is selected from styrene, vinyl acetate or vinylpyrrolidone.

[0036] Preferably, in the above preparation method, the adsorbent prepared in step 2) is further subjected to chloromethylation and amination, and then coupled with an anticoagulant; or the adsorbent prepared in step 2) is further subjected to sulfonation modification sex.

[0037] Preferably, in the above preparation method, the organic solvent is at least one of acetone and butanone.

[0038] Preferably, in the above preparation method, the polymer is porous sheet-like polyethylene, polyurethane, polycarbonate, microspherical ...

Embodiment 1

[0047]1) Take 1g of polyethylene sheet material (pore diameter 140um, can directly use commercial goods on the market), add 2.0wt% vinyl acetate, 2.5wt% maleic anhydride in acetone solution 50mL, use 60 Co gamma ray irradiation dose of 50kGy;

[0048] 2) Soak and rinse with acetone and 5% sodium hydroxide, and then clean with water for injection.

Embodiment 2

[0050] 1) Take 1g of polyethylene sheet material (pore diameter 130um, can directly use commercial goods on the market), add 2.5wt% styrene, 50mL of acetone solution of 2.5wt% maleic anhydride, and use 60 Co γ-ray irradiation dose of 30kGy;

[0051] 2) Soak and rinse with acetone and 5% sodium hydroxide, and then clean with water for injection.

[0052] After testing, the moisture content of the modified sheet after washing with injected water is 68%.

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Abstract

The invention discloses a chelating adsorbent for blood purification and a preparation method for the chelating adsorbent. The adsorbent comprises a macromolecular carrier which is grafted with a copolymer of maleic anhydride and styrene, vinyl acetate or vinyl pyrrolidone. According to an adsorbing material, a charge transfer complex can be formed by virtue of maleic anhydride and vinyl monomers and is grafted with a copolymer of maleic anhydride, so that the grafting amount of maleic anhydride is improved to a great extent; after the adsorbing material is hydrolyzed, the hydrophilicity of the adsorbing material can be improved so as to improve the blood compatibility. The maleic anhydride obtained by hydrolysis can be chelated with heavy metal ions in blood to form a relatively stable seven-membered ring structure, so that the selective absorption capacity on the heavy metal ions is improved, and therefore, other electrolyte cations are not greatly influenced while the heavy metal ions are removed from blood.

Description

technical field [0001] The invention relates to a material for blood purification and a preparation method thereof, in particular to a chelating adsorbent for blood purification and a preparation method thereof. Background technique [0002] Heavy metal poisoning refers to poisoning caused by heavy metal elements or their compounds with a relative atomic mass greater than 65, such as mercury poisoning, lead poisoning, etc. Because heavy metals can cause irreversible changes in the structure of proteins, thereby affecting the function of tissue cells and affecting human health. Especially workers who have been exposed to heavy metals for a long time are prone to chronic poisoning and occupational diseases. In addition, for patients with acute heavy metal poisoning, timely rescue is also necessary. On the basis of conventional drug treatment, combined with blood adsorption therapy, it can better remove the heavy metal toxins in the patient's body, improve the survival rate o...

Claims

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Application Information

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IPC IPC(8): B01J20/26B01J20/30A61M1/38
Inventor 李设桥姜建明
Owner 佛山市博新生物科技有限公司
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