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Medicine liquor for treating cervical cancer complication radiation proctitis through coloclysis

A technology for radiation proctitis and cervical cancer, which is applied in the field of traditional Chinese medicine, can solve the problems of low cure rate, affect the quality of life of patients, prolong the course of treatment, etc., and achieve the effects of being easy to master, protecting the intestinal mucosa, and simple to prepare

Inactive Publication Date: 2015-11-04
江琴
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Radiation proctitis not only affects the quality of life of patients, but also prolongs the course of treatment, causing unnecessary psychological pressure and economic burden on patients
At present, the amount of drug actually reaching the damaged rectal mucosa after systemic intravenous and oral administration is low, so the cure rate is low

Method used

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  • Medicine liquor for treating cervical cancer complication radiation proctitis through coloclysis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: the preparation of enema liquid

[0014] Weigh 0.25kg of pomegranate peel, 0.12kg of Eclipta, 0.09kg of white fresh peel, 0.07kg of xihe willow, 0.09kg of madder, 0.12kg of dog spine, 0.15kg of pulsatilla, 0.12kg of Phellodendron 0.12kg, 0.12kg of westerwort and 0.12kg of agrimony kg, combined, put in a multi-functional extractor, add water and decoct 3 times, add 12 times the amount of water for 2 hours for the first time, add 12 times the amount of water for 1.5 hours for the second time, add 10 times the amount for the third time decoct in water for 1.2h. Take 3 decoctions and combine them, add 0.3% diatomite filter aid after cooling down to room temperature, filter, concentrate the filtrate to 1.08-1.10g crude drug content per ml, add 0.02% preservative, stir to dissolve, extinguish Bacteria, can be filled by the specification of 100ml / bag, obtain enema medicinal liquid.

Embodiment 2

[0015] Embodiment 2: the preparation of enema liquid

[0016] Weigh 0.28kg of pomegranate peel, 0.15kg of Eclipta, 0.12kg of white fresh peel, 0.10kg of xihe willow, 0.12kg of madder, 0.12kg of dog spine, 0.20kg of pulsatilla, 0.15kg of Phellodendron 0.15kg, 0.15kg of westerwort and 0.15kg of agrimony kg, combined, put in a multi-functional extractor, add water and decoct 3 times, add 12 times the amount of water for 2 hours for the first time, add 12 times the amount of water for 1.5 hours for the second time, add 10 times the amount for the third time decoct in water for 1.2h. Combine the 3 decoctions, add 0.3% diatomite as a filter aid after cooling down to room temperature, filter, concentrate the filtrate to contain 1.10-1.15g of crude drug per ml, add 0.02% preservative, stir to dissolve, extinguish Bacteria, can be filled by the specification of 100ml / bag, obtain enema medicinal liquid.

Embodiment 3

[0017] Example 3: Study on the Curative Effect of Medicinal Liquid Enema on Radiation Proctitis Patients with Cervical Cancer

[0018] There were 58 patients with cervical cancer radiotherapy complicated with proctitis. Bloody stools and mucus stools were the main symptoms in all patients. All patients were diagnosed by colonoscopy, and pathological examinations were performed for erosions and ulcers to exclude the possibility of tumors. According to Sherman's grading: Grade 1: 40 cases of intestinal wall congestion or erosion; Grade 2: 16 cases of ulcer; grade 3 (both intestinal lumen stenosis) and grade 4 (fistula formation) patients were excluded. All patients were divided into control group and experimental group, with 29 cases in each group. There was no significant difference in age, primary disease, treatment method, and severity of radiation proctitis between the two groups, and they were comparable. The control group received gentamicin 80,000 units + dexamethasone 5...

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Abstract

The invention discloses medicine liquor for treating cervical cancer complication radiation proctitis through coloclysis. The medicine liquor is prepared from the following traditional Chinese medicinal materials in parts by weight: 21-29 parts of pomegranate bark, 9-15 parts of eclipta, 7-12 parts of the root bark of shaggy-fruited dittany, 5-10 parts of Chinese tamarisk twig, 7-12 parts of madder, 9-15 parts of rhizoma cibotii, 12-20 parts of the root of Chinese pulsatilla, 9-15 parts of amur corktree bark, 9-15 parts of herba siegesbeckiae, and 9-15 parts of hairyvein agrimony. The medicine liquor has multiple effects of astringing, relieving pain, stopping bleeding, diminishing inflammation and protecting intestinal mucosa, and is particularly suitable for treating the patients suffering from radiation proctitis; the preparation of the compound clysis fluid is simple, and low in cost.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a liquid enema for treating radiation proctitis of cervical cancer. Background technique [0002] Radiation enteritis is the most important complication after radiotherapy for cervical cancer, and the incidence rate is 10%-20% (Zhang Tianze, Xu Guangwei. Oncology (Volume 2) [M]. Tianjin: Tianjin Science and Technology Press, 1996:1921.), It can occur two weeks after starting radiation therapy, or it can occur between 6 months and two years after radiation therapy. It often manifests as increased stool frequency, falling discomfort, and even tenesmus, mucus, pus and blood in the stool, and in severe cases, it develops into intestinal ulcer, stricture, fistula, etc. Its pathogenesis is mainly as follows: the proliferation of intestinal epithelial cells is inhibited after the irradiation, and the intestinal submucosal arterioles are damaged, causing...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61P1/00
Inventor 不公告发明人
Owner 江琴
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