Recombinant human basic fibroblast growth factor instant gel preparation and preparation method thereof

A technology of fibroblasts and growth factors, applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of reducing bioavailability and administration cycle, and improve the ease of use Effects of usability and bioavailability, prolonged dosing period, and prolonged residence time

Active Publication Date: 2017-09-15
ZHUHAI ESSEX BIO PHARMA
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

thereby reducing its bioavailability and dosing cycle

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Recombinant human basic fibroblast growth factor instant gel preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] This embodiment provides recombinant human basic fibroblast growth factor instant gel preparation, including the following components: recombinant human basic fibroblast growth factor 5.0 mg, carbomer 9400.1 g, hypromellose (E4M) 0.1g, glycerin 0.1g, chlorobutanol 0.001g, appropriate amount of hydrochloric acid solution, add water for injection to 1000ml.

[0020] This embodiment also provides a preparation method of recombinant human basic fibroblast growth factor instant gel preparation, comprising the following steps:

[0021] A1: Add 5.0 mg of recombinant human basic fibroblast growth factor into the container;

[0022] A2: Add 0.1g of glycerin and 0.001g of chlorobutanol, and stir;

[0023] A3: Add 0.1 g of hydroxypropyl methylcellulose (E4M), and stir until a transparent solution is formed;

[0024] A4: Sprinkle carbomer 9400.1g into the container in batches, stir while adding, and keep stirring until the swelling is completely dispersed;

[0025] A5: Add water...

Embodiment 2

[0027] This embodiment provides recombinant human basic fibroblast growth factor instant gel preparation, including the following components: recombinant human basic fibroblast growth factor 30.0mg, carbomer 9400.3g, hypromellose (E4M) 1g, 2.5g glycerin, 0.1g chlorobutanol, appropriate amount of hydrochloric acid solution, add water for injection to 1000ml.

[0028] The preparation method of the instant gel preparation of recombinant human basic fibroblast growth factor provided in this example is the same as that in Example 1.

Embodiment 3

[0030] This embodiment provides recombinant human basic fibroblast growth factor instant gel preparation, including the following components: recombinant human basic fibroblast growth factor 40.0mg, carbomer 94020g, hypromellose (E4M) 50g , 20.0 g of glycerin, 10.0 g of chlorobutanol, an appropriate amount of hydrochloric acid solution, and water for injection was added to 1000 ml.

[0031] The preparation method of the instant gel preparation of recombinant human basic fibroblast growth factor provided in this example is the same as that in Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides an instant gel preparation of recombinant human basic fibroblast growth factor, which comprises the following components according to the weight ratio: 5.0×10-3-40×10-3 parts of recombinant human basic fibroblast growth factor, Poloxamer 2‑50 parts. The instant gel preparation of recombinant human basic fibroblast growth factor provided by the invention can prolong the retention time in eyes and improve the bioavailability.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a recombinant human basic fibroblast growth factor instant gel and a preparation method thereof. Background technique [0002] Basic Fibroblast Growth Factor (basic Fibroblast Growth Factor, bFGF) is a single-chain polypeptide composed of 146 amino acids, with a molecular weight of 17KD. biological activity. It is also a normal physiological component of corneal tissue, and it is distributed in all thicknesses of normal corneal tissue. Under normal conditions, bFGF mainly exists in the interstitium in the form of no or low activity. When the cornea is damaged, rFGF can stimulate the proliferation and migration of corneal epithelial cells, accelerate corneal epithelial regeneration and promote wound healing. Clinical trials have shown that bFGF eye preparations can delay and alleviate corneal epithelial reshedding damage to a certain extent. [0003] The dosage forms of reco...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/18A61K9/06A61K47/10A61K47/32A61K47/38A61P27/02
Inventor 曲伟许岩杨波方海洲郑赞顺
Owner ZHUHAI ESSEX BIO PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap