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Calcium peroxide microcapsule and preparation method thereof

A technology of calcium peroxide and microcapsules, which is applied to the active ingredients of peroxides, the digestive system, and pharmaceutical formulations to achieve the effects of simple and easy preparation methods, complete and uniform appearance, and prolonged drug release time

Active Publication Date: 2015-08-19
PEKING UNIV SCHOOL OF STOMATOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For this reason, the present invention will solve the problem of existing calcium peroxide microencapsulation, because calcium peroxide is easy to react with water, the method used in the present invention can avoid using water as a part in the reaction system, can also efficiently realize calcium peroxide simultaneously. Microencapsulation

Method used

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  • Calcium peroxide microcapsule and preparation method thereof
  • Calcium peroxide microcapsule and preparation method thereof
  • Calcium peroxide microcapsule and preparation method thereof

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Embodiment 1

[0031] Embodiment 1. The preparation of calcium peroxide microcapsules

[0032] The preparation method of calcium peroxide microcapsules of the present invention is as follows:

[0033] 1. Calcium peroxide pretreatment:

[0034] Use pulverizer to process calcium peroxide for 1 hour, the particle size of calcium peroxide powder after processing is 100-300nm, stand-by;

[0035] 2. Preparation of calcium peroxide microcapsules:

[0036] 1) Dissolve 2.4 g of ethyl cellulose in 50 mL of dichloromethane, use ethyl cellulose as the drug carrier, that is, the encapsulation material, and stir with a JJ-1 high-speed stirrer to completely dissolve the polymer ethyl cellulose;

[0037] 2) Disperse 19.2g of calcium peroxide in the solution (i.e. the drug to polymer input weight ratio is 8 to 1), set the rotation speed at 1200rpm, stir and disperse for 2h;

[0038] 3) Slowly add 160mL of petroleum ether into the reaction system at a rate of 2 drops / second; continue to stir and disperse f...

Embodiment 2

[0039] Embodiment 2. The preparation of calcium peroxide microcapsules

[0040] The preparation method of calcium peroxide microcapsules of the present invention is as follows:

[0041] 1. Calcium peroxide pretreatment:

[0042] Use pulverizer to process calcium peroxide for 1 hour, the particle size of calcium peroxide powder after processing is 100-300nm, stand-by;

[0043] 2. Preparation of calcium peroxide microcapsules:

[0044] 1) Mix polylactic acid and ethyl cellulose according to a certain ratio (the weight ratio is 8:1 respectively, and the mixed material is used as a drug carrier, that is, an encapsulation material; take 2.4g of the polymer and dissolve it in 50ml of dichloromethane, and use JJ- A type 1 high-speed stirrer stirs to completely dissolve the polymer; among them, the polylactic acid has a number average molecular weight of 28,000, a weight average molecular weight of 48,000, and a polydispersity coefficient of 1.71.

[0045] 2) Disperse 19.2g of calciu...

Embodiment 3

[0047] Embodiment 3. The preparation of calcium peroxide microcapsules

[0048] The preparation method of calcium peroxide microcapsules of the present invention is as follows:

[0049] 1. Calcium peroxide pretreatment:

[0050] Use pulverizer to process calcium peroxide for 1 hour, the particle size of calcium peroxide powder after processing is 100-300nm, stand-by;

[0051] 2. Preparation of calcium peroxide microcapsules:

[0052] 1) Dissolve 2.4g of ethyl cellulose in 50mL of dichloromethane, use ethyl cellulose as the drug carrier, that is, the encapsulation material, and stir with a JJ-1 high-speed stirrer to completely dissolve the polymer;

[0053] 2) Disperse 2.4g of calcium peroxide in the solution (that is, the weight ratio of drug to polymer input is 1:1), set the rotation speed at 1200rpm, and stir for 2h;

[0054] 3) Slowly add 160mL of petroleum ether into the reaction system at a rate of 2 drops / second; continue to stir and disperse for 2 hours at a speed of...

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Abstract

The invention discloses a preparation method of a calcium peroxide microcapsule. The method comprises the following steps: 1, dissolving a polymer in dichloromethane to obtain a polymer solution, wherein the polymer is ethylcellulose or a polylactic acid and ethylcellulose mixture; 2, adding calcium peroxide to the polymer solution obtained in step 1, and stirring for dispersion; and 3, adding petroleum ether to a reaction system obtained in step 2 in a dropwise manner, and stirring for dispersion to obtain the calcium peroxide microcapsule. The calcium peroxide microcapsule prepared through the preparation method has the advantages of controllable dimension, regular profile, and controllable drug release rate, and a pulvis is convenient for oral local application; and the preparation method has the advantages of simplicity, feasibility, high preparation efficiency, and convenience for large scale application.

Description

technical field [0001] The invention relates to a calcium peroxide microcapsule for local oral application and a preparation method thereof. Background technique [0002] Microencapsulation refers to the preparation of microcapsules (spheres), nanoparticles, micelles, liposomes and micropills (particles) using specific techniques. In a narrow sense, drug microencapsulation refers to the use of specific technologies to use natural, synthetic or semi-synthetic polymer materials to encapsulate drugs (form microcapsules) or disperse materials in polymer carriers (form microspheres). Microencapsulation can solve the shortcomings of traditional drugs, in which slow or controlled release of drugs through microencapsulation can reduce drug toxicity and prolong drug efficacy. [0003] Calcium peroxide is a white or yellow solid peroxide, which is a commonly used fungicide in the fields of food, fruit and vegetable preservation. The dry product is very stable at room temperature, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/40A61K9/52A61P1/02A61P31/04
Inventor 刘凯宁韩冰李小曼朱浚鑫袁重阳陈智滨王晓燕
Owner PEKING UNIV SCHOOL OF STOMATOLOGY
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