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Fenofibric acid glycine ethyl ester crystal form and preparation method thereof

A technology of acid glycine ethyl ester and fenofibrate, which is applied in the field of preparation of fenofibrate acid glycine ethyl ester salt crystal form, and achieves the effects of broad application prospects, improved stability and bioavailability, and simple process

Inactive Publication Date: 2015-07-29
TETRANOV PHARMA CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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  • Fenofibric acid glycine ethyl ester crystal form and preparation method thereof
  • Fenofibric acid glycine ethyl ester crystal form and preparation method thereof
  • Fenofibric acid glycine ethyl ester crystal form and preparation method thereof

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Embodiment 1

[0034] The crystal form of fenofibric acid glycine ethyl ester salt of the present embodiment is the crystal form of fenofibric acid glycine ethyl ester salt shown in structural formula (I):

[0035]

[0036] Its preparation method comprises the following steps:

[0037] 1) Get the fenofibric acid glycine ethyl ester salt shown in 20g structural formula (I) and be dispersed in 200ml isopropanol, obtain mixture;

[0038] 2) Warm up the mixture obtained in step 1) to 55° C., stir for 1 hour, and then perform hot filtration to obtain a filtrate;

[0039] 3) Cool the filtrate obtained in step 2) to 15°C, let it stand for crystallization for 24 hours, filter, wash the obtained solid with the filtrate obtained in step 2), and dry it in vacuum at 35°C for 24 hours to obtain the fenofibric acid Glycine ethyl ester salt crystal form.

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Abstract

The invention discloses a fenofibric acid glycine ethyl ester crystal form and a preparation method thereof. The crystal form is the fenofibric acid glycine ethyl ester crystal form shown in a structural formula (I) and is represented through a 2theta angle in an X-ray powder diffraction map, and X-ray powder diffraction peaks exist at the angles of 6.650 degrees, 8.010 degrees, 9.850 degrees, 12.350 degrees, 13.290 degrees, 14.620 degrees, 14.910 degrees, 16.090 degrees, 17.710 degrees, 18.430 degrees, 19.840 degrees, 20.049 degrees, 21.380 degrees, 22.290 degrees, 23.050 degrees, 23.460 degrees, 27.810 degrees and 33.760 degrees. The fenofibric acid glycine ethyl ester crystal form has high stability, the stability and the bioavailability of fenofibric acid glycine ethyl ester are greatly improved, and the fenofibric acid glycine ethyl ester has a broad application prospect in the hyperlipidemia treatment process.

Description

technical field [0001] The invention belongs to the technical field of compound crystal forms, and in particular relates to a fenofibric acid glycine ethyl ester salt crystal form, and also relates to a preparation method of a fenofibrate acid glycine ethyl ester salt crystal form. Background technique [0002] Hyperlipidemia is a kind of disease that seriously threatens human health, including high cholesterol, high triglycerides, high low-density lipoprotein, etc. These three diseases cause a series of common clinical diseases, such as coronary heart disease, angina pectoris, myocardial infarction Wait. Hyperlipidemia is a common and frequently-occurring disease, and with the aging of the population, hyperlipidemia is increasing year by year. [0003] Fenofibrate is a commonly used drug for the treatment of hyperlipidemia. It can effectively reduce the level of low-density lipoprotein and ultra-low-density lipoprotein, and at the same time can increase the level of high-d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C59/90C07C51/43C07C227/42C07C229/08A61P3/06
Inventor 吴豫生牛成山邹大鹏梁阿鹏谭延方郭瑞云李敬亚
Owner TETRANOV PHARMA CO LTD
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