Preparation of hepatic targeting nanoparticles carried with curcumin based on albumin serving as carrier material

A technology of albumin nanoparticles and curcumin, applied in the field of medicine

Inactive Publication Date: 2015-07-08
CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

After patent and literature search, there is no report on the technology of active targeted drug delivery system - glycyrrhetinic acid modified curcumin albumin nanoparticles

Method used

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  • Preparation of hepatic targeting nanoparticles carried with curcumin based on albumin serving as carrier material
  • Preparation of hepatic targeting nanoparticles carried with curcumin based on albumin serving as carrier material
  • Preparation of hepatic targeting nanoparticles carried with curcumin based on albumin serving as carrier material

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Embodiment

[0016] 1. Preparation of glycyrrhetinic acid active ester

[0017] (a) Weigh 1.0 g of glycyrrhetinic acid into a 50 mL round bottom flask, add 20.0 mL of anhydrous dimethyl sulfoxide to it, add 0.5 mL of triethylamine, and stir to dissolve.

[0018] (b) Add 0.94g of N,N'-dicyclohexylcarbodiimide (DCC) and 0.52g of N-hydroxysuccinimide (NHS) under stirring conditions, and stir at room temperature for 24h in the dark to obtain light yellow suspension. Filter to remove the by-product dicyclohexylurea in the reaction, then add anhydrous diethyl ether under stirring conditions to precipitate a solid and dry it in vacuum for 24 hours to obtain a light yellow solid powder.

[0019] 2. Preparation of Curcumin Albumin Nanoparticles

[0020] Weigh 0.0095-0.0104g of albumin powder and dissolve it in 1mL of ultrapure water, and weigh 0.0035-0.0044g of curcumin in 6mL of absolute ethanol, and add the ethanol solution of the drug dropwise at a speed of 0.1-5mL / min. Add 50.0 μL of 0.5% gl...

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Abstract

The invention discloses a preparation method of hepatic targeting nanoparticles carried with curcumin based on albumin serving as carrier material, belongs to the field of medicine, and in particular relates to prepare the hepatic targeting nanoparticles, curcumin albumin nanoparticles modified by glycyrrhetinic acid, through covalent binding. Each nanoparticle carried with medicine comprises the curcumin, the albumin and the glycyrrhetinic acid. The hepatic targeting nanoparticles are formed by the glycyrrhetinic acid binding to the surfaces of the albumin nanoparticles carried with the medicine. The prepared targeting nanoparticles have the effect of releasing, the glycyrrhetinic acid can mediate the curcumin albumin nanoparticles to target to a hepatic cell, the toxic and side effect of the medicine are lowered, the curative effect of the medicine is improved, the preparation craft is simple, the production cost is low, and wide application prospect is possessed.

Description

【Technical field】 [0001] The invention belongs to the field of medicine, and in particular relates to a preparation method of liver-targeting nanoparticles loaded with curcumin based on albumin 【Background technique】 [0002] Primary liver cancer is one of the common malignant tumors that seriously threaten human health in my country. Its morbidity and mortality are on the rise, and the economic burden it brings and the harm to social development are increasingly prominent. Chemotherapy is still the main means of clinical treatment of liver cancer at present, but due to the inability of conventional chemotherapy drugs to selectively transport to the lesion site, serious side effects occur. With the continuous development of liver-targeted drug delivery system research, extensive attention has been paid to the research on glycyrrhizic acid and glycyrrhetinic acid, the active ingredients in licorice at home and abroad, especially the covalent modification and structure-activit...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/42A61K47/28A61K31/12A61P1/16A61P35/00
Inventor 张良珂李静静邓凤李圳
Owner CHONGQING MEDICAL UNIVERSITY
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