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Intravenous injection lipid emulsion having anti-inflammatory and anti-thrombosis functions as well as preparation method and application thereof

A technology of fat emulsion and anti-inflammatory effect, which is applied in the field of medicine and can solve the problems of no obvious anti-inflammatory effect

Active Publication Date: 2015-07-01
JIANKANGYUAN PHARMA GROUP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has no obvious anti-inflammatory effect on patients with inflammation in the body

Method used

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  • Intravenous injection lipid emulsion having anti-inflammatory and anti-thrombosis functions as well as preparation method and application thereof
  • Intravenous injection lipid emulsion having anti-inflammatory and anti-thrombosis functions as well as preparation method and application thereof
  • Intravenous injection lipid emulsion having anti-inflammatory and anti-thrombosis functions as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] image 3 It is a diagram showing the influence of preparations of different examples on platelet aggregation induced by collagen (a) and arachidonic acid (b) (Example 1 (◆), Example 2 (■), Example 3 (▲))

[0072] The present invention is further described below through specific examples, but the following examples are only used to illustrate the present invention rather than limit the present invention.

[0073] The experimental methods in the following examples are conventional methods unless otherwise specified. The raw materials and reagent materials used in the following examples are all commercially available products unless otherwise specified. The eicosapentaenoic acid ethyl ester, eicosapentaenoic acid glyceride, butyric acid glyceride, fish oil rich in eicosapentaenoic acid ester and omega-3 unsaturated fatty acid glyceride, docosan Ethylpentaenoate, docosapentaenoic acid (DPA), docosapentaenoic acid-enriched seal oil, refined seal oil, and fur seal oil are a...

Embodiment 2

[0078] Add 20g of omega-3 fatty acid glycerides, 50g of docosapentaenoic acid glycerides, 20g of olive oil, 100g of medium-chain triglycerides, 300mg of oleic acid, and 200mg of α-tocopherol into a container, preheat To about 60 ~ 70 ℃, add 15g of soybean lecithin, vigorously stir until uniform dispersion, as the oil phase. 20 g of glycerol and 300 mg of sodium oleate were dissolved in 764 g of water as the water phase. Under the stirring condition of 10000 rpm, slowly add the oil phase into the water phase, stir for 5-10 minutes, and form milky white colostrum after uniform dispersion; adjust the pH to 6.5-8.5 (adjust the total weight of the fat emulsion to 1000g) , transferred to a high-pressure milk homogenizer, homogenized under 10000-15000Psi pressure for 6-10 times, sampling and measuring the particle size until the average particle size is below 0.5 microns, passed through a microporous filter membrane of 0.45 microns, and sterilized at 121 °C After 12 minutes, the obt...

Embodiment 3

[0080] Glyceryl eicosapentaenoate 15g, ethyl docosapentaenoate 20g, medium chain triglyceride 100g, soybean oil 60g, ascorbyl palmitate 400mg, oleic acid 300mg, α-tocopherol 100mg, Add it into a container, preheat it to about 60-70°C, add 17g of refined egg yolk lecithin, stir vigorously until it is evenly dispersed, and use it as the oil phase. 25 g of propylene glycol was dissolved in 760 g of water as the aqueous phase. Under the stirring condition of 10000 rpm, slowly add the oil phase into the water phase, stir for 5-10 minutes, and form milky white colostrum after uniform dispersion; adjust the pH to 7.0-9.0 with sodium hydroxide (adjust the total The weight is 1000g), transferred to the high-pressure milk homogenizer, homogenized under the pressure of 10000-15000Psi for 6-10 times, sampling and measuring the particle size until the average particle size is less than 0.5 micron, passing through the microporous membrane of 0.45 micron, 121 ℃ Sterilize at high temperature...

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Abstract

The invention relates to an intravenous injection lipid emulsion having anti-inflammatory and anti-thrombosis functions as well as a preparation method and an application thereof. The lipid emulsion consists of anti-inflammatory lipid, lipid having an anti-platelet aggregation function, an emulsifier, polyhydric alcohol and other pharmaceutical accessories, wherein the anti-inflammatory lipid is lipid which can form timnodonic acid or butyric acid through metabolism in vivo; and the lipid having an anti-platelet aggregation function is lipid which can form docosapentaenoic acid through metabolism in vivo. On one hand, the lipid emulsion disclosed by the invention can effectively relieve inflammatory reaction in patients, and can significantly reduce platelet aggregation and reduce the risk of high-risk thrombosis on the other hand. In addition, by virtue of reasonable lipid composition, the lipid emulsion can improve metabolism rate of fatty acid lipid and accelerate energy supply.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a fat emulsion for intravenous injection with anti-inflammation and anti-thrombosis effects and its preparation method and application. Background technique [0002] Fat emulsion is a new drug dosage form that has developed rapidly in recent years. It can provide the fat and energy needed by human nutrition. It is suitable for patients who need high energy, kidney damage, forbidden protein, and those who cannot take food through the gastrointestinal tract for some reason. Patients are mainly used for the treatment of symptoms such as inability to eat before and after major surgery, severe energy consumption, chronic diarrhea, extensive burns, malignant tumors, severe nutritional deficiencies, and essential fatty acid deficiencies, and provide nutritional support and energy for the above-mentioned patients. [0003] Soybean oil is the main source of fatty acids in cur...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K35/35A61K31/232A61K31/22A61P29/00A61P7/02A61P9/00A61P19/02A61P1/00A61P35/00
Inventor 甘勇赵凤光张馨欣任鹏王晓丽梁卫文李菲菲朱春柳
Owner JIANKANGYUAN PHARMA GROUP
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