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Disinfecting and sterilizing medical ultrasonic coupling agent with moisturizing and skin-moistening effects and preparation method of disinfecting and sterilizing medical ultrasonic coupling agent

An ultrasonic coupling agent, disinfection and sterilization technology, applied in medical preparations containing active ingredients, echo/ultrasonic imaging agents, pharmaceutical formulations, etc. Antibiotic properties, good biocompatibility, and fast-acting effects

Inactive Publication Date: 2015-06-24
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007]3. The existing medical couplants use propylene glycol, glycerol or polyethylene glycol as heat preservation agents, and these substances can only function as products during the storage of couplants. Stability and moisturizing effect, wiped off immediately after use, the moisturizing effect on the skin is not obvious, and symptoms such as dry skin, itching, redness and swelling are often felt after ultrasound examination, although allantoin is used as an anti-irritant ingredient in CN101716354A, but due to The solubility of allantoin is low, and the amount of allantoin in the gel is more than 0.2% and it is easy to separate out, but the effect is poor below this concentration. In all the examples in CN101716354A, the amount of allantoin used is 0.1%

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1). Prepare materials according to the quality of each material in Table 1

[0034] Table 1 The feeding quality of each material and the percentage of the total mass (based on the preparation of 100 kg)

[0035] Material name Feeding quality (kg) Percentage of total mass (%) Polyhexamethyleneguanidine hydrochloride 0.1 0.1 2-Hydroxypropyltrimethylammonium Chloride Chitosan 4 4 Cationic Guar Gum 2 2 Allantoin basic aluminum chloride 0.4 0.4 water soluble vitamin E 0.1 0.1 Glycerol 5 5 distilled or purified water 88.4 88.4

[0036] (2) Prepare according to the following steps

[0037] The first step: take 5 kilograms of glycerol and 88.4 kilograms of distilled water, stir and mix to obtain a mixed solution;

[0038] The second step: heat and boil the mixed solution prepared in the first step to 100°C, and remove the air;

[0039] Step 3: Cool the mixed solution prepared in the second step to 60-70°C, ad...

Embodiment 2

[0053] (1). Prepare materials according to the quality of each material in Table 1

[0054] Table 1 The feeding quality of each material and the percentage of the total mass (based on the preparation of 100 kg)

[0055] Material name Feeding weight (kg) Percentage of total weight (%) Polyhexamethyleneguanidine hydrochloride 0.5 0.5 N-Trimethylammonium Chloride Chitosan 3 3 Cationic cellulose JR-400 6 6 Allantoin basic aluminum chloride 0.8 0.8 water soluble vitamin E 0.3 0.3 Glycerol 15 15 distilled or purified water 74.4 74.4

[0056] (2) Prepare according to the following steps

[0057] The first step: take 15 kilograms of glycerol and 74.4 kilograms of distilled water, stir and mix to obtain a mixed solution;

[0058] The second step: heat and boil the mixed solution prepared in the first step to 100°C, and remove the air;

[0059] Step 3: Cool the mixed solution prepared in the second step to 60-70°C, add...

Embodiment 3

[0065] (1). Prepare materials according to the quality of each material in Table 1

[0066] Table 1 The feeding quality of each material and the percentage of the total mass (based on the preparation of 100 kg)

[0067] Material name Feeding weight (kg) Percentage of total weight (%) polyhexamethyleneguanidine phosphate 0.1 0.1 2-Hydroxypropyltrimethylammonium Chloride Chitosan 4 4 Cationic Guar Gum 1 1 Cationic cellulose JR-400 4 4 Allantoin basic aluminum chloride 1.0 1.0 water soluble vitamin E 0.1 0.1 Glycerol 12 12 distilled or purified water 77.8 77.8

[0068] (2) Prepare according to the following steps

[0069] The first step: take 12 kilograms of glycerol and 77.8 kilograms of distilled water, stir and mix to obtain a mixed solution;

[0070] The second step: heat and boil the mixed solution prepared in the first step to 100°C, and remove the air;

[0071] The third step: the mixed solution pr...

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Abstract

The invention relates to a disinfecting and sterilizing medical ultrasonic coupling agent with moisturizing and skin-moistening effects and a preparation method of the disinfecting and sterilizing medical ultrasonic coupling agent. The coupling agent comprises the following raw materials in percentage by weight: 0.1%-0.5% of polyhexamethylene guanidine, 1%-4% of cationic chitosan, 1%-8% of a cationic polymer, 0.4%-1.5% of allantoin polyaluminum chloride, 0.1%-0.5% of water-soluble vitamin E, 5%-20% of glycerin and the balance of distilled water. The preparation technology comprises the following steps: measuring distilled water and glycerin, stirring and mixing evenly, heating to 100 DEG C; when cooling water to 60-70 DEG C, adding polyhexamethylene guanidine, cationic chitosan, cationic polymer, allantoin polyaluminum chloride and water-soluble vitamin E under agitation; and further slowly stirring for 30-60 minutes, standing for 24 hours, filling and packaging. The medical ultrasonic coupling agent prepared by the method has the advantages of fast disinfecting and sterilizing effects, no corrosion on an ultrasonic probe, few bubbles (clear image), excellent biocompatibility and high lubricating property, and has moisturizing and skin-moistening efficacies; meanwhile, the preparation technology is simple and environmentally friendly; large-scale production is easy to realize; and the cost is low.

Description

technical field [0001] The invention relates to a medical ultrasonic coupling agent, in particular to a disinfecting and sterilizing medical ultrasonic coupling agent with moisturizing and moisturizing effects and a preparation method thereof. Background technique [0002] The clarity and resolution of ultrasonic diagnostic images not only depend on the quality of the diagnostic instrument itself, but also are closely related to the quality of the sound-conducting medium, that is, the ultrasonic coupling agent. Medical ultrasonic coupling agent refers to the intermediary medium used to transmit sound waves that is filled or applied between the skin (or mucous membrane) and the probe (or treatment head) during ultrasonic diagnosis and treatment operations. With the widespread application of ultrasonic diagnostic technology, while bringing convenience, problems such as cross-infection due to the use of coupling agents, dryness, and allergies after use cannot be ignored. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K31/785A61P31/02A61K31/722
Inventor 刘红杜鹏韩凤梅陈勇
Owner HUBEI UNIV
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