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Preparation method of biodegradable nano-microsphere and application

A nano-microsphere, biodegradable technology, used in medical science, prosthesis, etc., to achieve uniform particle size, improve facial contours, and simplify post-processing processes.

Active Publication Date: 2015-06-03
杨青芳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the development and application of biodegradable polymer nanospheres as filling materials for orthopedic filling and repairing injection gels or as cell carriers has not been reported yet.

Method used

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  • Preparation method of biodegradable nano-microsphere and application
  • Preparation method of biodegradable nano-microsphere and application
  • Preparation method of biodegradable nano-microsphere and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The preparation method of the biodegradable nano microspheres of the present embodiment comprises the following steps:

[0040] Step 1, the viscosity average molecular weight is 6.0×10 5 PHB was dissolved in chloroform to obtain solution A; the mass percentage of PHB in solution A was 8%;

[0041]Step 2, adding the solution A obtained in step 1 into the emulsifier solution, and then placing it under ultrasonic waves for ultrasonic dispersion to obtain an emulsion; the volume of the emulsifier solution is 10 times the volume of the solution A; the emulsifier solution is obtained by The composition of the following mass percentage content: polyvinyl alcohol 1%, polyoxyethylene 0.10%, the balance is water; the temperature of the ultrasonic dispersion is 52 ℃, the power is 1000W, and the time is 18s; the polyvinyl alcohol The molecular weight is 7.7×10 4 , the molecular weight of polyoxyethylene is 2.5×10 6 ;

[0042] Step 3, carrying out negative pressure distillation ...

Embodiment 2

[0051] This example is the same as Example 1, except that the biodegradable material is PHBV, PHB-PEG copolymer, PLA, PLGA, PCL or PDLLA-PEG-PDLLA copolymer, or PHB, PHBV, At least two of PHB-PEG copolymer, PLA, PLGA, PCL, and PDLLA-PEG-PDLLA copolymer.

Embodiment 3

[0053] The preparation method of the biodegradable nano microspheres of the present embodiment comprises the following steps:

[0054] Step 1. Make the viscosity-average molecular weight 3.0×10 5 PHBV was dissolved in chloroform to obtain solution A; the mass percentage of PHBV in solution A was 5%;

[0055] Step 2, adding the solution A obtained in step 1 into the emulsifier solution, and then placing it under ultrasonic waves for ultrasonic dispersion to obtain an emulsion; the volume of the emulsifier solution is 15 times the volume of the solution A; the emulsifier solution is made of The composition of the following mass percentage content: polyethylene glycol 3%, polyoxyethylene 0.05%, the balance is water; the temperature of the ultrasonic dispersion is 55 ℃, the power is 900W, and the time is 15s; the polyethylene glycol The molecular weight of alcohol is 0.9×10 3 , the molecular weight of polyoxyethylene is 1.5×10 6 ;

[0056] Step 3, carrying out negative pressur...

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Abstract

The invention discloses a preparation method of a biodegradable nano-microsphere. The method comprises the following steps: 1, dissolving a biodegradable material into an organic solvent to obtain a solution A; 2, adding an emulsifier solution to the solution A, and carrying out ultrasonic dispersion to obtain an emulsified liquid; 3, carrying out negative pressure distillation on the emulsified liquid and discharging the organic solvent to prepare a suspension liquid; 4, pouring the suspension liquid into ethanol water, washing, standing, participating and filtering to obtain filtrate; and 5, carrying out spray drying on filtrate to obtain the biodegradable nano-microsphere. In addition, the invention further discloses an application of the prepared biodegradable nano-microsphere. The biodegradable nano-microsphere prepared by the invention is milk white, transparent or semi-transparent, tasteless, and uniform and consistent in particle size, and can completely meet the nano-microsphere size requirements for injection and application. The biodegradable nano-microsphere is combined with medical hydrogel, and can respectively play good filling and repairing roles at a short period, a middle period and a long period after being injected into a body.

Description

technical field [0001] The invention belongs to the technical field of soft tissue repair and molding processing of tissue engineering materials, and in particular relates to a preparation method and application of biodegradable nano microspheres. Background technique [0002] Biodegradable medical materials refer to materials that can be used to implant into organisms or combine with biological tissues, such as: PHB, PHBV, PHB-PEG copolymer, PLA, PLGA, PCL and PDLLA-PEG-PDLLA copolymer and other materials. With the development of material science and the advancement of biomedical science, the application of biomaterials involves almost every field of biomedicine. Therefore, biodegradable medical polymer products have received more and more attention according to their functionality and molding processing methods for different purposes. [0003] Clinical studies in recent years have shown that people have successfully prepared biodegradable polymer materials into orthopedi...

Claims

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Application Information

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IPC IPC(8): A61L27/26A61L27/18A61L27/50A61L27/58
Inventor 杨青芳艾玉峰
Owner 杨青芳
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