Pellet type pantoprazole sodium enteric capsule and preparation method thereof
A technology of pantoprazole sodium and enteric-coated capsules, applied in the field of medicine, can solve the problems of insufficient release of active ingredients, easy degradation of active ingredients, large gastrointestinal irritation, etc., and achieves improved bioavailability, good curative effect reproducibility, The effect of improving solubility
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Embodiment 1
[0027] A micropill type pantoprazole sodium enteric-coated capsule is a sustained-release preparation, and the micropill type pantoprazole sodium enteric-coated capsule is composed of a capsule shell and pantoprazole sodium mixed uniformly contained in the capsule shell. Composition of azole sodium pellets, pantoprazole sodium pellets are blank ball core, main drug layer, isolation layer, enteric-coated layer successively from inside to outside, main drug layer weight is 14% of blank ball core, and isolation layer weight is 9% of the total weight of the blank core and the main drug layer, and the weight of the enteric layer is 28% of the total weight of the blank core, the main drug layer and the isolation layer, wherein 40% of the pantoprazole sodium pellets are outside the enteric layer Also coat the pigment layer, the pigment layer weight is 0.5% of the total weight of the blank ball core, the main drug layer, the isolation layer and the enteric layer, the diameter of the bl...
Embodiment 2
[0039] A micropill type pantoprazole sodium enteric-coated capsule is a sustained-release preparation, and the micropill type pantoprazole sodium enteric-coated capsule is composed of a capsule shell and pantoprazole sodium mixed uniformly contained in the capsule shell. Composition of azole sodium pellets, pantoprazole sodium pellets are blank ball core, main drug layer, isolation layer, enteric-coated layer successively from inside to outside, main drug layer weight is 20% of blank ball core, and isolation layer weight is 9.3% of the total weight of the blank core and the main drug layer, and the weight of the enteric layer is 29% of the total weight of the blank core, the main drug layer and the isolation layer, wherein 45% of the pantoprazole sodium pellets are outside the enteric layer Also coat the pigment layer, the pigment layer weight is 0.7% of the total weight of the blank ball core, the main drug layer, the isolation layer and the enteric coating layer, the diameter...
Embodiment 3
[0051] A micropill type pantoprazole sodium enteric-coated capsule is a sustained-release preparation, and the micropill type pantoprazole sodium enteric-coated capsule is composed of a capsule shell and pantoprazole sodium mixed uniformly contained in the capsule shell. Composed of azole sodium pellets, the pantoprazole sodium pellets are successively blank core, main drug layer, isolation layer, enteric-coated layer from inside to outside, the weight of the main drug layer is 30% of the blank core, and the isolation layer Weight is 9.5% of the total weight of blank ball core and main drug layer, and the weight of enteric layer is 30% of blank ball core, main drug layer and isolation layer total weight, wherein the pantoprazole sodium pellets of 50% are in enteric coat Also coat pigment layer outside the layer, the weight of pigment layer is 0.8% of the total weight of blank ball core, main drug layer, isolation layer and enteric coating layer, the diameter of blank ball core ...
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