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Preparation and application of anti-inflammatory effective part of rhaponticum uniflorum

A technology of effective parts and leaking reed flowers, which is applied in the field of medicine, can solve the problems of anti-inflammatory activity and unclear pharmacological mechanism, and achieve the effects of clear active ingredients and mechanism of action, strong operability, and good separation effect

Active Publication Date: 2015-04-08
BEIJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Leuluhua has a long history of clinical use and strong anti-inflammatory pharmacological activity in Mongolian medicine, its anti-inflammatory activity and pharmacological mechanism are still unclear

Method used

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  • Preparation and application of anti-inflammatory effective part of rhaponticum uniflorum
  • Preparation and application of anti-inflammatory effective part of rhaponticum uniflorum
  • Preparation and application of anti-inflammatory effective part of rhaponticum uniflorum

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Grind 1Kg of the medicinal material of Reedflower into coarse powder, add 15Kg of 75% ethanol, reflux extraction twice, each time for 1.5 hours, filter, recover the solvent from the filtrate, dry under reduced pressure, and obtain the alcohol extract (CEE) of Reedflower.

[0028] (2) Dilute the above-mentioned Alcohol extract of Aloe chinensis with water, the liquid extract of Aloe chinensis: water=1:8 (weight), the dilution is enriched through the AB-8 type macroporous adsorption resin column, first use deionized water 4BV ( Resin volume) elution, then elution with 70% ethanol 8BV, collect the eluent, reclaim the solvent under reduced pressure to obtain a fluid extract, and dry the fluid extract to obtain 0.20Kg of the anti-inflammatory effective part extract of Lehmania chinensis.

Embodiment 2

[0030] (1) Grind 1Kg of the medicinal material of Reedflower into coarse powder, add 12Kg of 60% ethanol, reflux extraction twice, each time for 1 hour, filter, recover the solvent from the filtrate, and dry under reduced pressure to obtain the ethanol extract (CEE).

[0031] (2) Dilute the above-mentioned Alcohol Extract of Leuflora with water, water extract: water=1:10 (weight), the dilution is enriched through D101 type macroporous adsorption resin column, first use deionized water 3BV (resin volume ) elution, then eluted with 80% ethanol 7BV, collected the eluent, and recovered the solvent under reduced pressure to obtain a fluid extract, which was dried to obtain 0.23Kg of the anti-inflammatory effective part extract of Lehmania chinensis.

Embodiment 3

[0033] Tablet preparation: extract 200g of the effective part of the flower of the flower, add 175g of hydroxypropyl methylcellulose, 60g of micropowder silica gel, and 2g of magnesium stearate, mix well, pass through a 80-mesh sieve, and dry Granules, compressed tablets.

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Abstract

The invention discloses a preparation and an application of an anti-inflammatory effective part of rhaponticum uniflorum. The preparation method comprises the following main steps: carrying out reflux extraction on rhaponticum uniflorum with ethyl alcohol, and recovering ethyl alcohol; separating an alcohol extract with D101 or AB-8 macroporous resin; and eluting with 50%-90% ethyl alcohol, and concentrating and drying an eluant, so as to obtain the anti-inflammatory effective part of the rhaponticum uniflorum. The anti-inflammatory effective part of the rhaponticum uniflorum disclosed by the invention has relatively good anti-inflammatory activity on acute and chronic inflammations, and is simple in process and suitable for industrialized production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular, the invention relates to a preparation method (extraction and separation) of the anti-inflammatory effective part of the Mongolian medicine Leu reed flower and the application of the effective part. Background technique [0002] Inflammation is a very common and important basic pathological process, which can occur in any part of the body and any tissue. Most human diseases are often related to inflammatory processes. Inflammation is also the most important protective response of the body, and the long-term survival of human beings is inseparable from the inflammatory response. But in some cases, the inflammatory reaction also has different degrees of harm to the body, and the severe inflammatory reaction can even endanger the life of the patient. Therefore, it will be of great significance to actively develop various drugs to prevent and control the adverse effects of inflam...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P29/00C07J9/00C07H15/26C07H1/08C07C65/03C07C51/48C07D311/30C07D311/40C07H17/07C07C53/126A61K133/00
CPCA61K36/28A61K2236/333A61K2236/39A61K2236/55C07C51/42C07D311/30C07D311/40C07H1/08C07H15/26C07H17/07C07J9/00C07C65/03C07C53/126
Inventor 李霄邓振涛图雅李泽琳肖向茜赵爱娟
Owner BEIJING UNIV OF TECH
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