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Novel application of honghuaxiaoyao preparation to treatmentt of premature ovarian failure

A technology for premature ovarian failure and new uses, which is applied in the directions of medical preparations containing active ingredients, plant raw materials, sexual diseases, etc., can solve the problems of premature ovarian failure without relevant literature and patent reports, etc. good, energy and cost savings

Inactive Publication Date: 2018-09-14
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the clinical application and literature reports of safflower Xiaoyao preparation are mainly aimed at chest and hypochondrium pain, dizziness, loss of appetite and irregular menstruation, but there are no relevant literature and patent reports for the treatment of premature ovarian failure.

Method used

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  • Novel application of honghuaxiaoyao preparation to treatmentt of premature ovarian failure
  • Novel application of honghuaxiaoyao preparation to treatmentt of premature ovarian failure
  • Novel application of honghuaxiaoyao preparation to treatmentt of premature ovarian failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Angelica 260kg, Radix Paeoniae Alba 260kg, Atractylodes macrocephala 260kg, Poria cocos 260kg, safflower 50kg, saponin thorn 80kg, bamboo leaf Bupleurum 260kg, mint 10kg, licorice 195kg, starch 150kg, magnesium stearate 10kg, a total of 1,000,000 safflowers were made Xiaoyao tablets (0.39g / tablet).

[0018] And the following preparation steps are adopted: (1) After crushing Angelica, Atractylodes Rhizoma Atractylodes Rhizome and Peppermint, soak the medicinal materials with 12 times the amount of water for 1.5 hours, then steam distill for 4 hours, extract volatile oil, and set aside; Safflower, saponins, bupleurum and licorice are crushed into fine powders with a diameter of about 20 μm, and the dregs extracted in step (1) are added with water and decocted, and the amount of water added is 10 times the weight of the medicinal materials , decoct 2 times, 2 hours each time, filter, combine the filtrate, and set aside. (3) Concentrate the filtrate of step (2) under reduc...

Embodiment 2

[0089] Angelica 780kg, Radix Paeoniae Alba 780kg, Atractylodes macrocephala 780kg, Poria cocos 780kg, safflower 150kg, saponins thorn 240kg, bamboo leaf Bupleurum 780kg, mint 30kg, licorice 585kg, dextrin 500kg, made 3,000,000 safflower Xiaoyao capsules (0.4g / grain).

[0090] And the following preparation steps are adopted: (1) After crushing Angelica, Atractylodes Rhizoma Atractylodes Rhizome and Peppermint, soak the medicinal materials with 12 times the amount of water for 1.5 hours, then steam distill for 4 hours, extract volatile oil, and set aside; Grind safflower, saponins, bupleurum and licorice into a fine powder with a diameter of about 30 μm, add water and decoct together with the dregs extracted in step (1), the amount of water added is 10 times the weight of the medicinal materials , decoct 2 times, 2 hours each time, filter, combine the filtrate, and set aside; (3) Concentrate the filtrate of step (2) under reduced pressure into a thick paste with a relative dens...

Embodiment 3

[0092] Angelica 520kg, Radix Paeoniae Alba 520kg, Atractylodes Rhizoma Atractylodis 520kg, Poria 520kg, Safflower 100kg, Saponaria thorn 160kg, Bamboo Leaf Bupleurum 520kg, Mint 20kg, Licorice 390kg, Microcrystalline Cellulose 100kg, HPMC K4M 250kg, Magnesium Stearate 20kg, A total of 2,000,000 safflower Xiaoyao sustained-release tablets (0.4g / tablet) were made.

[0093] And the following preparation steps are adopted: (1) After crushing Angelica, Atractylodes Rhizoma Atractylodes Rhizome and Peppermint, soak the medicinal materials with 12 times the amount of water for 1.5 hours, then steam distill for 4 hours, extract volatile oil, and set aside; Safflower, saponins, bupleurum and licorice are crushed into fine powders with a diameter of about 20 μm, and the dregs extracted in step (1) are added with water and decocted, and the amount of water added is 10 times the weight of the medicinal materials , decocted 2 times, each 2 hours, filtered, combined filtrate, standby; (3) w...

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Abstract

The invention relates to the field of traditional Chinese medicine preparations, in particular to novel application of a honghuaxiaoyao preparation to treatmentt of premature ovarian failure. The honghuaxiaoyao preparation is prepared as follows: taking nine traditional Chinese medicines such as radix angelicae sinensis, radix paeoniae alba, rhizoma atractylodis macrocephalae, poria cocos, flos carthami, Chinese honeylocust spine, radix bupleuri, herba menthae and radix glycyrrhizae as raw materials; and extracting and separating active ingredients through a relatively improved extracting andseparating technology to prepare various preparations. Through a modern extracting and separating technology, extracting and separating effects are relatively good, a volatile oil extracting rate is relatively high, sufficient utilization of medical materials is facilitated, energy resource and cost are reduced, and product quality is improved. More importantly, the honghuaxiaoyao preparation is firstly applied to treat premature ovarian failure, so that a novel application is developed for clinical application of the honghuaxiaoyao preparation.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to the new application of safflower Xiaoyao preparation in treating premature ovarian failure. Background technique [0002] Premature ovarian failure (POF) refers to a gynecological disease in which women under the age of 40 experience amenorrhea, decreased estrogen secretion, and increased gonadotropin levels due to ovarian failure. Premature ovarian failure has always been a difficult point in reproductive medicine that has always been plagued by treatment. In recent years, the incidence rate has been increasing year by year. POF not only leads to clinical symptoms such as amenorrhea, secondary infertility, and low estrogen in young women, but also affects the nervous system, cardiovascular and cerebrovascular, endocrine, bone and other multiple organs in the whole body, seriously affecting the physical and mental health of patients. ...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K36/65A61P15/00A61P15/08
CPCA61K36/076A61K36/232A61K36/233A61K36/284A61K36/286A61K36/483A61K36/484A61K36/534A61K36/65A61K36/71A61K2236/331A61P15/00A61P15/08A61K2300/00
Inventor 李小锋刘厚权周朝忠李海金梁佳
Owner JIANGXI POZIN PHARMA
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