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Synthesis method of MnO nanometer material of T1 contrast agent

A technology of nanomaterials and synthesis methods, which is applied in the field of synthesis of T1 contrast agent MnO nanomaterials, can solve the problems of inconspicuous particle contrast effect, uneven particle size, unfavorable modification, etc., and achieve good biological safety, good dispersibility, good dispersion effect

Inactive Publication Date: 2015-03-25
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, as far as the inorganic material such as manganese oxide is concerned, the contrast effect of the prepared particles is often not obvious, that is, the r1 value is low, which is not conducive to further modification and multifunctional imaging.
The synthesis of manganese oxide nanoparticles often has a series of problems such as uneven particle size and poor dispersion to varying degrees, making it difficult to put into practical applications

Method used

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  • Synthesis method of MnO nanometer material of T1 contrast agent
  • Synthesis method of MnO nanometer material of T1 contrast agent
  • Synthesis method of MnO nanometer material of T1 contrast agent

Examples

Experimental program
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Effect test

Embodiment 1

[0027] A method for synthesizing T1 contrast agent MnO magnetic nanoparticles, the steps are as follows:

[0028] 1) According to the molar ratio determined in advance, measure 3ml (6.8mmol) of trioctylamine and 0.8ml (2.4mmol) of oleic acid into a 100ml three-necked bottle, stir and mix well, and the solution can be seen to be clear and colorless. Then weigh 0.22g (0.8mmol) of manganese acetate light pink powder in the above mixed solution, fully stir until the powder is more evenly dispersed in the solution.

[0029] 2) Move the three-necked flask with the reaction system prepared in step 1) to the heating mantle, adopt a slightly open reaction mode, heat the reaction temperature from room temperature to 320°C, and set the reaction time at the target reaction temperature to 60min. After the reaction was complete, it was naturally cooled to room temperature.

[0030] 3) Pour the reaction product into a beaker, add excess absolute ethanol for sedimentation, and collect by cen...

Embodiment 2

[0040] A method for synthesizing T1 contrast agent MnO magnetic nanoparticles, the steps are the same as in Example 1, except that trioctylamine is 6.8 mmol, oleic acid is 2.4 mmol, and manganese acetate is 0.8 mmol. The reaction temperature is 310° C., and the reaction time is 30 minutes.

Embodiment 3

[0042]A method for synthesizing T1 contrast agent MnO magnetic nanoparticles, the steps are the same as in Example 1, except that 6.8 mmol of trioctylamine, 3.2 mmol of oleic acid, and 2 mmol of manganese acetate are used. The reaction temperature is 320° C., and the reaction time is 60 minutes.

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Abstract

The invention discloses a synthesis method of a MnO nanometer material of a T1 contrast agent, and relates to a magnetic nanometer material. The method comprises the following steps: mixing trioctylamine with an oleic acid solution evenly; adding manganese acetate powder; dispersing, carrying out heating reaction, and cooling to room temperature; and participating and centrifuging reaction products, and washing, so as to obtain the MnO nanometer material of the T1 contrast agent. The method for preparing the MnO nanometer material of the T1 contrast agent is simple to operate; a reactant is cheap, and low in cost; the reaction is rapidly finished; the required time is short; the synthesis method hardly causes side reactions and high in product yield; energy utilization rate is high; the reaction process is free from generation of harmful substances and is energy-saving and environment-friendly; and the MnO nanometer material has good paramagnetism and T1 contrast effect; r1 value is 2.369mM<-1>s<-1>; and the prepared MnO magnetic nanometer particles are uniform in particle size, have good dispersity and stability, and can be stored for a long period of time after being dispersed in cyclohexane.

Description

technical field [0001] The invention relates to a magnetic nano material, in particular to a method for synthesizing a T1 contrast agent MnO nano material. Background technique [0002] Magnetic resonance imaging MRI (Magnetic resonance imaging) is a non-invasive imaging method that uses magnetic resonance phenomena, computer technology and two-dimensional image reconstruction methods for imaging. It has high imaging rate, no ionizing radiation, and can provide multi-level diagnostic information. Therefore, it has been widely used in medical testing. Magnetic nanoparticles have superparamagnetic properties, which can increase the imaging sensitivity of magnetic resonance imaging, thus exhibiting a unique contrast agent function. [0003] T1 contrast agents are mostly transition metals or lanthanide metals, because they have more single electrons and larger magnetic moments in the outermost layers of their atoms. The most common T1 contrast agent is the chelate of Gd(Ⅲ), wh...

Claims

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Application Information

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IPC IPC(8): A61K49/18
Inventor 周樨雷胜岚陈志伟任磊
Owner XIAMEN UNIV
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