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Application of dry curcumin nano-powder inhalant in treatment of acute lung injury

A technology for dry powder inhalation and acute lung injury, which is applied in the field of medicine and can solve the problems that there are no specific drugs for acute lung injury.

Inactive Publication Date: 2015-03-18
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, there is no clinically effective drug for acute lung injury

Method used

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  • Application of dry curcumin nano-powder inhalant in treatment of acute lung injury
  • Application of dry curcumin nano-powder inhalant in treatment of acute lung injury
  • Application of dry curcumin nano-powder inhalant in treatment of acute lung injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1. curcumin liposome dry powder inhalation

[0044] Take 100mg of curcumin, 320mg of soybean lecithin, and 30mg of cholesterol in an eggplant-shaped bottle, add 5ml of tetrahydrofuran to dissolve completely, and then rotatively evaporate in a water bath at 35°C to remove the organic solvent, forming a thin layer of uniform film on the inner wall of the eggplant-shaped bottle. Add 200ml of pH 5.0 phosphate buffer solution with 2.26g of lactose into the eggplant-shaped bottle, place at 37°C and shake at a constant temperature of 100 rpm for 1 hour to fully hydrate it. Ultrasonic dispersion 10min after taking out, obtains curcumin liposome suspension ( figure 1 ). Curcumin liposomes are obtained by spray-drying curcumin liposome dry powder inhalation ( figure 2 ). The spray drying parameters are as follows: air inlet temperature: 100°C, air outlet temperature: 50°C, fan power: 55Hz, peristaltic pump speed: 280mL / h, firing pin interval: 2 seconds.

[0045] G...

Embodiment 2

[0046] Embodiment 2. curcumin solid lipid nanoparticle dry powder inhalation

[0047] Take 50mg of curcumin, 0.7g of glyceryl monostearate, and 800.03g of Tween in a beaker and heat to 80°C, gradually add 10ml of 80°C water containing 10mg of sodium lauryl sulfate, keep the temperature constant, and it becomes a transparent liquid ; and then inject it into 0 ℃ water with high-speed stirring containing 1.2g of lactose with a syringe, and it becomes a transparent liquid; observed under a scanning electron microscope, most of them are particles below 100 nanometers. Curcumin solid lipid nanoparticles are spray-dried to obtain curcumin solid lipid nanoparticles dry powder inhalation. The spray drying parameters are as follows: air inlet temperature: 100°C, air outlet temperature: 50°C, fan power: 55Hz, peristaltic pump speed: 280mL / h, firing pin interval: 2 seconds.

Embodiment 3

[0048] Embodiment 3. curcumin nanoemulsion dry powder inhalation

[0049] Take 50 mg of curcumin and dissolve it in 5 ml of ethyl oleate / tetrahydrofuran mixed solvent, add appropriate amount of polyoxyethylene castor oil and monoglyceride, heat and stir to form a solution, add about 4 ml of water under high-speed stirring conditions, and continue stirring to obtain half Transparent dispersion liquid. The results of particle size measurement show that most of the particles are below 120nm, which is curcumin nanoemulsion. Get 100mg mannitol and add in 4ml curcumin nanoemulsion for dissolving, freeze-dry in freeze dryer to obtain curcumin nanoemulsion powder with good fluidity. Take 100 mg of curcumin nanoemulsion powder and mix with 100 mg of Inhalac230 lactose produced by Meggle to obtain curcumin nanoemulsion dry powder inhalation.

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Abstract

The invention discloses an application of a dry curcumin nano-powder inhalant in treatment of acute lung injury. The dry curcumin nano-powder inhalant is prepared from a curcumin nanometer administration system. The dosage form of the curcumin nanometer administration system is selected from a liposome, a nano-particle, a nano-emulsion and a micro-emulsion. The curcumin nanometer administration system with or without auxiliary materials is dried to form a solid powder, and the solid powder is mixed with a carrier to obtain the dry curcumin nano-powder inhalant. The dry curcumin nano-powder inhalant has the advantages of stable drugs, easy entrance of the deep portion of lung tissues, targeted positioning, carrying and use convenience, and benefiting for the treatment of the acute lung injury. The dry curcumin nano-powder inhalant is used for treating acute lung injury caused by infection, shock, smoking, wounds, poisoning, irritating gas inhalation, radiation, high oxygen and low oxygen. Irritating gases comprise phosgene, diphosgene, triphosgene, chlorine, nitrogen oxide, formaldehyde, dimethyl sulfate, hydrogen chloride, hydrogen bromide, hydrogen fluoride, ammonia, ozone and sulfur dioxide.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of curcumin nano dry powder inhalation in the treatment of acute lung injury. Background technique [0002] Turmeric is a commonly used traditional Chinese medicine, which is recorded in various editions of "Chinese Pharmacopoeia". Curcumin is an active ingredient extracted from the rhizomes of turmeric, zedoary and other plants in the ginger family. The molecular formula of curcumin is C 21 h 20 o 6 , is a polyphenolic compound with a β-diketone structure. The pure product is orange-yellow needle-shaped crystals with a special odor, slightly acidic, and easily decomposed when exposed to light. Curcumin is easily soluble in glacial acetic acid and alkali solution, soluble in methanol, ethanol, propylene glycol and acetone, insoluble in cold water and petroleum ether. Curcumin is a highly photosensitive substance that needs to be stored away from light. It is unstable ...

Claims

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Application Information

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IPC IPC(8): A61K9/72A61K9/14A61K31/12A61P11/00
Inventor 金义光李淼杜丽娜张晶
Owner ACADEMY OF MILITARY MEDICAL SCI
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