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Laminated microneedle system and preparation method thereof

A microneedle and lamination technology, applied in the field of microneedle arrays, can solve the problems of limited hardness of soluble materials, insufficient compression resistance, unfavorable operation, etc. Effect

Inactive Publication Date: 2015-02-11
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Solid microneedles are easy to operate, but the microchannels formed by microneedles on the skin are limited by time; coated microneedles are simple to prepare, but limit the drug dose; hollow microneedles can deliver liquid drugs, but the fabrication is complicated and the needles are easy to install. Dangerous due to breakage in the body
[0003] Soluble microneedles have the advantages of avoiding the safety hazard caused by the breakage of microneedle needles made of metal or silicon materials in the body, and the advantages of simple production, but there are still some disadvantages, mainly including several points: soluble materials will have certain effects on the activity of drugs and vaccines. The hardness of the soluble material is limited, so the needle body cannot penetrate the stratum corneum of the skin as a whole, which reduces the drug delivery rate and increases the waste of drugs and vaccines; the base has insufficient compression resistance and is easy to break during the pressure application process , is not conducive to the operation

Method used

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  • Laminated microneedle system and preparation method thereof
  • Laminated microneedle system and preparation method thereof
  • Laminated microneedle system and preparation method thereof

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preparation example Construction

[0024] The preparation method of the laminated microneedle system provided by the invention (see image 3 ), specifically include the following steps:

[0025] (a) Making a microneedle master 5: preparing a microneedle master of silicon material or metal material by using micro-nano processing technology, laser cutting or mechanical engraving;

[0026] (b) Make microneedle template 6: Mix polydimethylsiloxane prepolymer and curing agent in a volume ratio of 8:1 to 12:1 (the curing agent is preferably a silicone rubber curing agent or other types of curing agent) agent), after fully stirring evenly and vacuuming, remove the air bubbles, then pour the liquid polydimethylsiloxane with curing agent onto the microneedle motherboard, and place it in an oven at 70-85°C for 1 to 2 hours. Obtain solid polydimethylsiloxane, and then tear it off from the microneedle master to form a microneedle template with arrayed microholes;

[0027] (c) Preparation of the outer layer of the needle ...

Embodiment 1

[0034] (a) Microneedle master plate of stainless steel material prepared by laser cutting method;

[0035] (b) Fabrication of polydimethylsiloxane microneedle templates using microneedle masters. Mix polydimethylsiloxane prepolymer and silicone rubber curing agent at a volume ratio of 8:1, stir well and vacuumize, remove air bubbles, and then add the liquid polydimethylsiloxane with curing agent Pour alkane onto the microneedle master, place it in an oven at 70°C for 2 hours, and obtain solid polydimethylsiloxane, which is then torn off from the microneedle master to form an array of microneedles. Porous polydimethylsiloxane microneedle template;

[0036] (c) Preparation of the outer layer of the needle body: After mixing the silk fibroin solution with a mass volume ratio of 7.8% and 0.2IU insulin in a volume ratio of 4:1 to form a mixed solution, the needle body array with a volume of 3 / 4 The total volume of the mixed solution was poured onto the polydimethylsiloxane micron...

Embodiment 2

[0040](a) Microneedle master plate of silicon material prepared by micro-nano processing technology;

[0041] (b) Fabrication of polydimethylsiloxane microneedle templates using microneedle masters. Mix the polydimethylsiloxane prepolymer and the silicone rubber curing agent at a volume ratio of 10:1, stir well and vacuumize, remove the air bubbles, and then add the curing agent to the liquid polydimethylsiloxane Pour alkane onto the microneedle master, place it in an oven at 80°C for 1.5 hours to obtain solid polydimethylsiloxane, and then tear it off from the microneedle master to form an array of microneedles. Porous polydimethylsiloxane microneedle template;

[0042] (c) Preparation of the outer layer of the needle body: After mixing the hyaluronic acid solution with a mass volume ratio of 15% and the hepatitis B vaccine of 20 μg / mL in a volume ratio of 10:1 to form a mixed solution, the needle with a volume of 5 / 8 The mixed solution of the total volume of the body array...

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Abstract

The invention relates to a laminated microneedle system and a preparation method thereof and belongs to the technical field of medical devices. A laminated structure, namely an outer layer and an inner layer of a needle body, is prepared from a soluble natural polymer material or a high molecular polymer. The outer layer of the needle body for wrapping a target drug has good soundness, can easily penetrate keratoderma, can be rapidly dissolved in a skin environment rich in water, and exerts an effect of releasing the target drug. The inner layer of the needle body cannot penetrate skin and therefore is free of the target drug. The system can strengthen a skin penetration effect of the needle body and reduce waste of the target drug at the same time. A base of the system has better compression resistance, and the problem of frangibility of the base under pressure is improved. The preparation method is easy, avoids high-temperature treatment, facilitates keeping activity of the target drug and is easy and simple to operate.

Description

technical field [0001] The present invention relates to a microneedle array for transdermal drug delivery. The present invention has good targeting, and releases target substances such as medicines and vaccines at the target site, thereby achieving higher drug delivery efficiency. Background technique [0002] The microneedle system improves the shortcomings of the traditional transdermal drug delivery method, and has the advantages of painlessness, easy operation, and miniaturization, and brings hope to patients who have endured the pressure caused by drug injection for a long time. Microneedles are usually processed by bio-oriented micro-electromechanical technology (MEMs), and are mainly divided into four categories: solid microneedles, coated microneedles, soluble microneedles, and hollow microneedles. Solid microneedles are easy to operate, but the microchannels formed by microneedles on the skin are limited by time; coated microneedles are simple to prepare, but limit...

Claims

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Application Information

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IPC IPC(8): A61M37/00B81B1/00
CPCA61M37/0015A61K9/0021A61M2037/0046A61M2037/0053
Inventor 刘冉罗欣莹仰雪瑶
Owner TSINGHUA UNIV
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