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Carboxymethyl chitosan microsphere embolization agent and preparation method thereof

A technology of carboxymethyl chitosan microspheres and carboxymethyl chitosan, which is applied in the field of medicine and chemical industry, can solve the problems of time-consuming and labor-intensive, high lethality, easy to cause ectopic embolism, etc., and achieve stable and uniform quality and safety factor High, operable effect

Active Publication Date: 2015-02-11
SHIJIAZHUANG YISHENGTANG MEDICAL SUPPLIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of using microspheres in interventional therapy is to embolize the blood vessels in the lesion. The uniformity of the particle size of the microspheres is very high, and the general deviation should be less than 15%. The particle size of the microspheres required for interventional embolization therapy is generally 50. ~500μm, which belongs to small particle size microspheres. Within this particle size range, the particle size difference will further increase under the same process. Ordinary microspheres are used for interventional therapy with poor curative effect, easy to cause ectopic embolism, high fatality rate, and poor safety. , in order to make up for the defect of uneven particle size, precision screening is required, which is not only time-consuming and laborious, but also causes material loss and high cost
[0005] Therefore, there is a lack of carboxymethyl chitosan microspheres suitable for interventional therapy in the prior art, which can meet the requirements of small particle size, high uniformity, degradability and tissue compatibility that embolization technology should possess for microspheres. requirements, improve the safety and effectiveness of interventional therapy, and reduce production costs

Method used

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  • Carboxymethyl chitosan microsphere embolization agent and preparation method thereof
  • Carboxymethyl chitosan microsphere embolization agent and preparation method thereof
  • Carboxymethyl chitosan microsphere embolization agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Adopt the following method to prepare carboxymethyl chitosan microsphere embolic agent:

[0060] (1) Carboxymethyl chitosan pretreatment: weigh 20g of carboxymethyl chitosan, dissolve it in a sodium chloride solution with a mass fraction of 0.9%, filter out the insoluble matter, and obtain carboxymethyl chitosan with a mass fraction of 2%. base chitosan solution;

[0061] (2) Emulsification reaction: Adjust the temperature of the reactor to 45°C, add 140g of Span 80 to 4L of liquid paraffin to disperse, and after the temperature of the reactor is constant, add the carboxymethyl chitosan solution obtained in step (1) to the liquid paraffin In the middle, adjust the rotation speed and stir to obtain a stable emulsification system;

[0062] (3) Crosslinking reaction: Slowly add 60ml of glutaraldehyde aqueous solution with a concentration of 50% dropwise, and the reaction time is 4 hours. After the reaction is completed, stop stirring and discharge the material. Washed 4 ...

Embodiment 2

[0067] Adopt the following method to prepare carboxymethyl chitosan microsphere embolic agent:

[0068] (1) Carboxymethyl chitosan pretreatment: weigh 20g of carboxymethyl chitosan, dissolve it in a sodium bicarbonate solution with a mass fraction of 1%, filter out the insoluble matter, and obtain carboxymethyl chitosan with a mass fraction of 2%. base chitosan solution;

[0069] (2) Emulsification reaction: Adjust the temperature of the reactor to 45°C, add 100g of Span 80 to 4L of liquid paraffin to disperse, and after the temperature of the reactor is constant, add the carboxymethyl chitosan solution obtained in step (1) to the liquid paraffin In the middle, adjust the rotation speed and stir to obtain a stable emulsification system;

[0070] (3) Cross-linking reaction: Slowly add 40ml of glutaraldehyde aqueous solution with a concentration of 50% dropwise, and the reaction time is 2 hours. After the reaction is completed, stop stirring and discharge the material. Washed ...

Embodiment 3

[0075] Adopt the following method to prepare carboxymethyl chitosan microsphere embolic agent:

[0076] (1) Carboxymethyl chitosan pretreatment: weigh 20g of carboxymethyl chitosan, dissolve it in a sodium carbonate solution with a mass fraction of 1%, filter out insoluble matter, and obtain carboxymethyl chitosan with a mass fraction of 2%. Chitosan solution;

[0077] (2) Emulsification reaction: adjust the temperature of the reactor to 45°C, add 160g of Span 80 to 4L of liquid paraffin to disperse, and after the temperature of the reactor is constant, add the carboxymethyl chitosan solution obtained in step (1) to the liquid paraffin In the middle, adjust the rotation speed and stir to obtain a stable emulsification system;

[0078] (3) Cross-linking reaction: Slowly add 50ml of glutaraldehyde aqueous solution with a concentration of 50% dropwise, and the reaction time is 3 hours. After the reaction is completed, stop stirring and discharge the material. Washed 4 times wit...

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Abstract

The invention relates to a carboxymethyl chitosan microsphere embolization agent. The embolization agent takes carboxymethyl chitosan as raw materials; the carboxymethyl chitosan is subjected to pretreatment, emulsification, cross-linking and dehydration drying to prepare microspheres with three-dimensional network structures. After the microspheres absorb water, the microspheres are smooth in surface and are rich in elasticity, have good biocompatibility and biodegradablity and is suitable for non-permanent vascular embolization.

Description

technical field [0001] The invention belongs to the field of medicine and chemical industry, and relates to the application technology of polymer materials, in particular to a carboxymethyl chitosan microsphere embolic agent and a preparation method thereof. Background technique [0002] With the rapid development of modern medicine, in addition to conventional drug therapy and surgical treatment, a new treatment method, that is, interventional therapy is becoming more and more mature. The key to interventional therapy is to use microspheres of appropriate particle size to embolize blood vessels in the lesion, cut off the blood supply to the diseased tissue, and achieve the purpose of inhibiting the development of the disease. effect. [0003] Chitosan is a natural polysaccharide, and its derivatives such as carboxymethyl chitosan also show excellent effects such as low toxicity, high degradability, and high biocompatibility. Recently, chitosan and its derivatives have been...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/14A61L31/16
Inventor 李素哲贾晓伟李鹏达程志甄苏刘媞高亚琪
Owner SHIJIAZHUANG YISHENGTANG MEDICAL SUPPLIES
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