Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Method for extraction and preparation of jatrorrhizine and application of jatrorrhizine in preparation of medicine for prevention and treatment of colon cancer

A jatrorrhizine and alkaline technology, which is applied in drug combination, antineoplastic drugs, organic chemistry, etc., can solve the problems of cumbersome separation of silica gel column bands, unsuitability for industrial production, and high cost, and achieve short cycle time and low cost. Low, easy-to-operate effect

Inactive Publication Date: 2015-02-04
CHINA PHARM UNIV
View PDF6 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method uses macroporous resin for elution, and the strip separation process of silica gel column is cumbersome, and the cycle is long and the cost is high, so it is not suitable for industrial production

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for extraction and preparation of jatrorrhizine and application of jatrorrhizine in preparation of medicine for prevention and treatment of colon cancer
  • Method for extraction and preparation of jatrorrhizine and application of jatrorrhizine in preparation of medicine for prevention and treatment of colon cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Get 1kg of Gonggong wood medicine powder and add in the extraction container, add 12L of 0.2% acid alcohol (50%) solution, reflux, merge the filtrate, reclaim the solvent, concentrate the medicinal solution, adjust the pH to 10 with alkali, leave standstill, and filter. After the filtrate was concentrated, the pH was adjusted to 2, 15% sodium chloride was added, allowed to stand, and filtered. After drying the precipitate, redissolve with 30 times the volume of alkaline aqueous solution, reflux, adjust the pH of the filtrate to 10, adjust the pH to 2 after the filtrate is concentrated, add 15% sodium chloride, stand still, and filter. Dry the precipitate. The precipitate was redissolved with 20 times the volume of alkaline aqueous solution, refluxed, and filtered. The precipitate was redissolved with an aqueous solution of 9, filtered, and the filtrate was concentrated, allowed to stand, and filtered to obtain a dry precipitate whose content was 89.1% as detected by HP...

Embodiment 2

[0024] Take 1 kg of coptis powder and add it to the extraction container, add 12L of 0.2% acetic acid alcohol (50%) solution, reflux, combine the extracts, recover the solvent, concentrate the liquid, then adjust the pH to 9 with alkali, let it stand, and filter. After the filtrate was concentrated, the pH was adjusted to 1, 15% sodium chloride was added, allowed to stand, and filtered. After drying the precipitate, redissolve with 30 times the volume of alkaline aqueous solution, reflux, filter, adjust the pH of the filtrate to 9, stand still, filter, adjust the pH to 1 after the filtrate is concentrated, add 15% sodium chloride, stand still, and filter. Dry the precipitate. The precipitate was redissolved with 10 times the volume of alkaline aqueous solution, refluxed once, and filtered. The precipitate was redissolved with an aqueous solution of pH 9, filtered, the filtrate was concentrated, allowed to stand, and filtered to obtain a dry precipitate whose content was 91.3%...

Embodiment 3

[0026] Get Phellodendron Phellodendron medicinal powder 1kg and add in the extraction container, add 12L of 0.2% acid alcohol (50%) solution, reflux, combine extract, recover solvent, concentrate medicinal liquid, then adjust pH to 9 with alkali, stand still, filter. After the filtrate was concentrated, the pH was adjusted to 1, 15% sodium chloride was added, allowed to stand, and filtered. After drying the precipitate, redissolve with 30 times the volume of alkaline aqueous solution, reflux, filter, adjust the pH of the filtrate to 9, stand still, filter, adjust the pH to 1 after the filtrate is concentrated, add 15% sodium chloride, stand still, and filter. Dry the precipitate. The precipitate was redissolved with 10 times the volume of alkaline aqueous solution, refluxed once, and filtered. The precipitate was redissolved with an aqueous solution of pH 9, filtered, the filtrate was concentrated, allowed to stand, and filtered to obtain a dry precipitate whose content was 8...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a method for extraction and preparation of jatrorrhizine from a traditional Chinese medicinal material and application of jatrorrhizine in preparation of medicine for prevention and treatment of colon cancer. The preparation method adopts an acid-base system solvent method and comprises the following steps: grinding the traditional Chinese medicinal material, adding an acidic (0.1%-2%) aqueous solvent for reflux extraction, recycling the solvent and carrying out an acid-base solvent method to obtain jatrorrhizine of which the purity is greater than 80%. Jatrorrhizine prepared by the method has the advantages of high purity, short period and low cost and the preparation method is friendly to the environment and suitable for industrial production.

Description

technical field [0001] The invention relates to a method for extracting and preparing jatrorrhizine from traditional Chinese medicine by using an acid-base solvent method and its application in medicines for preventing and treating colon cancer. Background technique [0002] Jatrorrhizine is a former berberine-type isoquinoline alkaloid with a molecular formula of C20H20N04, a molecular weight of 338.39, a reddish-yellow needle crystal, and a melting point of 208-210°C. It has a wide range of physiological activities, including antibacterial, analgesic, antihypertensive, immune regulation and other functions, and has a wide range of applications in the field of medicine. [0003] Gongluomu, Coptis chinensis, Cortex Phellodendron, Huangteng, and Three Needles are the medicinal materials recorded in the Chinese Pharmacopoeia 2010 Edition. , boils, carbuncles, dysentery and jaundice hepatitis. Modern pharmacological studies have shown that they all have antibacterial, antiulc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D455/03A61K31/4375A61P35/00
CPCC07D455/03
Inventor 张春凤张素丽
Owner CHINA PHARM UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com