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Preparation with contrast-enhanced ultrasound and photothermal therapy properties, preparation method and application thereof

A technology of photothermal therapy and contrast-enhanced ultrasound, which is applied to echo/ultrasound imaging agents, medical preparations containing active ingredients, and pharmaceutical formulations, etc., which can solve the problems of wide particle size distribution of microcapsules, cumbersome preparation process, and ineffective matching. , to achieve the effect of improved light-to-heat conversion efficiency, simple preparation process, and excellent mechanical properties

Active Publication Date: 2017-07-07
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This invention has the following disadvantages: (1) The organic solvent will remain when the polymer microcapsules are prepared by the double-emulsion solvent evaporation method, which will affect its further application; The probe frequency cannot be effectively matched

Method used

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  • Preparation with contrast-enhanced ultrasound and photothermal therapy properties, preparation method and application thereof
  • Preparation with contrast-enhanced ultrasound and photothermal therapy properties, preparation method and application thereof
  • Preparation with contrast-enhanced ultrasound and photothermal therapy properties, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: A preparation method of a preparation with ultrasound contrast and photothermal therapy properties, comprising the following steps:

[0034] (1) Pipette 0.25 mL of polystyrene microsphere water suspension (590 nm, 5wt%) and disperse it into a mixed solvent composed of 7 mL of deionized water and 30 mL of isopropanol, sonicate in a water bath for 5 min, and then add ammonia water to adjust the pH value to 10.8, add 0.2 mL ethyl orthosilicate, stir and hydrolyze for 30 min, then add 0.02 mL of 3-aminopropyltriethoxysilane to continue the reaction for 3 h, deionized water and ethanol are alternately centrifuged and washed three times to obtain surface amino groups Crystallized core-shell microspheres;

[0035](2) Transfer the core-shell microspheres prepared in step (1) to a THF hot solvent at 80 °C, stir for 8 h, and centrifuge and wash three times with deionized water to obtain hollow SiO with surface amination. 2 ball;

[0036] (3) Add citrate-modified g...

Embodiment 2

[0041] Embodiment 2: A preparation method of a preparation with ultrasound contrast and photothermal therapy properties, comprising the following steps:

[0042] (1) Pipette 0.5 mL of polystyrene microsphere suspension (1200 nm, 2.5 wt%) and disperse it into a mixed solvent consisting of 7 mL of deionized water and 30 mL of isopropanol, ultrasonicate in a water bath for 5 min, and then add ammonia water to adjust the pH value to 11.0, add 0.4 mL ethyl orthosilicate, stir and hydrolyze for 30 min, then add 0.1 mL of 3-aminopropyltriethoxysilane to continue the reaction for 3 h, deionized water and ethanol are alternately centrifuged and washed three times to obtain the surface amino group Crystallized core-shell microspheres;

[0043] (2) Transfer the core-shell microspheres prepared in step (1) to a THF hot solvent at 80 °C, stir for 8 h, and centrifuge and wash three times with deionized water to obtain hollow SiO with surface amination. 2 ball;

[0044] (3) Add citrate-mod...

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Abstract

The invention relates to the field of biomedical materials, in particular to a preparation with ultrasound contrast and photothermal therapy properties, a preparation method and application thereof. Firstly, hollow SiO2 spheres are prepared by the template method, and then surface seeding and chemical reduction methods are used to coat gold nanoshells on the surface, and finally, moisture is removed by vacuum freeze-drying, and gas is filled to obtain an integrated photothermal diagnosis and treatment guided by ultrasound images. chemicals. The hollow SiO2 sphere containing gas has a good response to ultrasound for clinical diagnosis, and the gold nanoshell coated with the outer layer can convert the light energy of the absorbed near-infrared laser into heat energy, which is used to kill malignant tumor cells. The invention combines ultrasonic diagnosis and photothermal therapy preparations into one, locks the lesion through ultrasound contrast-enhanced examination, and then applies laser irradiation to carry out photothermal therapy under the guidance of ultrasonic images, which reduces the pain of patients and improves the treatment efficiency. efficiency.

Description

technical field [0001] The invention belongs to the field of medical preparations, and in particular relates to a preparation with performances of ultrasound contrast and photothermal therapy, its preparation method and application. Background technique [0002] Tumor diagnosis is the premise of tumor treatment. It is of great significance to select the appropriate diagnostic agent, visualize the tumor, and accurately locate the tumor and its spread. Among the medical imaging diagnostic methods commonly used in clinical practice, ultrasound diagnosis plays an important role in the diagnosis of tumors due to its many outstanding advantages, such as intuitive, no radiation, low price, real-time imaging and suitable for bedside. [0003] Ultrasound contrast agents are a class of diagnostic reagents that can significantly enhance ultrasonic scattering signals. They are usually coated microbubbles with a diameter of several hundred nanometers to tens of micrometers. In most cases...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/22A61K41/00A61P35/00
Inventor 邢占文陈瑶刘卫卫
Owner SUZHOU UNIV
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