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Pharmaceutical composition containing pioglitazone and glimepiride

A technology of pioglitazone glimepiride and pioglitazone hydrochloride, applied in the field of medicine

Inactive Publication Date: 2015-01-21
SICHUAN HAISCO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Not for use in type 1 diabetes, diabetic ketosis, and prediabetic coma or coma treatment

Method used

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  • Pharmaceutical composition containing pioglitazone and glimepiride
  • Pharmaceutical composition containing pioglitazone and glimepiride
  • Pharmaceutical composition containing pioglitazone and glimepiride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Put 30g of pioglitazone, 240mL of acetone-acetonitrile mixed solvent (volume ratio 3:1), 20mL of concentrated hydrochloric acid (37%) into a 500mL reaction flask, stir and heat up to reflux for 70 minutes, add 2g of activated carbon, reflux for 10 minutes, and filter while hot. The filtrate was cooled and crystallized, filtered with suction, and the filter cake was dried at 55°C to obtain 21.6 g of pioglitazone hydrochloride.

[0022] Powder X-ray diffraction: gained pioglitazone hydrochloride uses Cu-K radiation, and the X-ray powder diffraction (XRPD) collection of patterns of this compound is shown in the attached figure 1 .

[0023] Differential scanning calorimetry analysis: the differential scanning calorimetry analysis spectrum of pioglitazone hydrochloride is shown in the attached figure 2 .

Embodiment 2

[0025]

Embodiment 3

[0027]

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PUM

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Abstract

The invention provides a pharmaceutical composition containing pioglitazone and glimepiride. Glimepiride which is one of components of the pharmaceutical composition disclosed by the invention can be used for lowering the blood sugar of a patient with II diabetes by stimulating insulin to release from a functional pancreatic beta cell. By virtue of a non-insulin mechanism, the glimepiride further can be used for increasing the sensitivity of a peripheral tissue to insulin. Another component pioglitazone hydrochloride is a peroxysome proliferator-activated receptor-gamma agonist with strong effect and high selectivity, and capable of lowering the insulin resistance of livers and the peripheral tissue, so that the insulin-dependent glucose utilization is increased, and the output of hepatic glucose is lowered.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a pharmaceutical composition containing pioglitazone glimepiride. Background technique [0002] With the improvement of diagnosis and treatment of diabetes prevention and treatment, the life expectancy of diabetic patients increases and the course of disease prolongs. The emergence of diabetic complications such as heart, brain, kidney, vascular disease and neuropathy has become a problem that cannot be ignored. These complications have accounted for 70% of the causes of diabetes deaths. %, therefore, the clinical and experimental research on chronic complications of diabetes is gradually becoming a necessity. [0003] People with type 2 diabetes can effectively control blood sugar when they first use sulfonylurea drugs, and then the curative effect gradually decreases or even fails, which is called secondary failure of sulfonylurea drugs. The main reasons are as follows: First, the prol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/64A61P3/10A61K31/4439
CPCA61K31/64A61K31/4439A61K2300/00
Inventor 任东冯卫陈九龙
Owner SICHUAN HAISCO PHARMA CO LTD
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