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A kind of medicine and application thereof for prevention and treatment of obesity and related diseases

A technology for obesity and drugs, applied in the field of cell biology, can solve the problems that the pharmacological mechanism is rarely reported, and the level of cytomolecular science is yet to be explored, so as to achieve the effect of strengthening and enhancing synergy

Active Publication Date: 2018-08-31
南京优而生物科技发展有限公司
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0006] Although the green tea polyphenols (GTP) extracted from green tea have been widely known for anti-oxidation, anti-aging, and prevention and treatment of metabolic syndrome and other diseases, the profound pharmacological mechanism has yet to be explored, especially at the molecular level
The unique Australian wild kangaroo products are also widely used as nutritional health products, but the pharmacological mechanism is rarely reported

Method used

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  • A kind of medicine and application thereof for prevention and treatment of obesity and related diseases
  • A kind of medicine and application thereof for prevention and treatment of obesity and related diseases
  • A kind of medicine and application thereof for prevention and treatment of obesity and related diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 Real-time quantitative RT-PCR was used to analyze the effects of KBF and GTP on the induction of bone marrow mesenchymal stem cells into fat and osteoblasts.

[0035] like figure 1 As shown, real-time quantitative RT-PCR was used to analyze the effect of mysysclein KBF and green tea polyphenol GTP on the induction of bone marrow mesenchymal stem cells into adipose and osteoblasts. Among them, (A): the expression of KBF and GTP on the adipocyte-specific biomarker Pparg gene of bone marrow mesenchymal stem cells. The bone marrow mesenchymal stem cells were cultured on the first day and the 14th day in the basic culture medium (DS-) and the special culture medium (DS+) for stimulating and inducing adipocytes, and 5 μg / ml green tea polyphenol GTP could also be added to the special culture medium, Or 1-10 μg / ml KBF, or both. a Pa Pc Pa Pc Pd P<0.001, compared with the corresponding treatment group added with 1-10 μg / ml KBF.

[0036] Real-time quantitative RT-PCR...

Embodiment 2

[0059] Example 2 Zucker rats can be induced to become obese by a high-fat diet, and this animal model is used as a standard experimental model for studying obesity.

[0060] Table 1: Experimental scheme of the Zucker obese rat model;

[0061]

[0062] After Zucker rats were treated with normal diet, high-fat diet and high-fat diet plus GTP or / and KBF for 4 months, observe whether GTP or / and KBF can prevent induction of obesity and osteoporosis, and observe whether they can also be used for treatment the disease.

[0063] The experimental design is detailed in Table 1 and explained as follows:

[0064] As a negative control group, a normal diet, 11 kcal / g, containing 14% fat;

[0065] ·As a positive control group, a high-fat diet, 20 kcal / g, containing 43.5% fat, induces obesity;

[0066] High-fat diet plus 200 mg GTP / kg body weight in the treatment group;

[0067] The treatment group received a high-fat diet plus 200 mg KBF / kg of body weight;

[0068] · In the treatmen...

Embodiment 3 5

[0082] Example 3 The clinical application of GTP and KBF-GTP to the treatment records of obesity in the past five years.

[0083] Diagnosis of obesity based on BMI;

[0084] The therapeutic dose is 1 gram of KBF and 0.5 gram of GTP per day;

[0085] The blood test report data before treatment and 6 months after treatment were used as analysis;

[0086] Observation indicators include BMI, blood pressure, total cholesterol, triglyceride, lipoprotein, alanine aminotransferase, aspartate aminotransferase;

[0087] · Observation indicators for some patients also include fasting blood glucose, erythrocyte sedimentation rate, renal function indicator creatinine, serum vitamin D, etc.

[0088] Table 2: Clinical treatment records of GTP and GTP-KBF over the past five years

[0089]

[0090] Note: Each data represents mean ± SE. * P** P<0.05, there is statistical significance comparing the corresponding value before treatment with GTP alone. The blood test report data at the time ...

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Abstract

A medicine combining kangaroo bone factors and green tea polyphenols and used for treating and preventing obesity and related diseases and applications of the medicine are provided. The medicine comprises the kangaroo bone factors (KBF) and the green tea polyphenols (GTP), wherein the mass ratio of the kangaroo bone factors (KBF) to the green tea polyphenols (GTP) is 1-2:1. According to the ratio of the kangaroo bone factors (KBF) to the green tea polyphenols (GTP), when the medicine is used for research on mesenchymal stem cell directional cell induction, 10-20 micrograms per milliliter of the kangaroo bone factors (KBF) and 1-10 micrograms per milliliter of the green tea polyphenols (GTP) are used together; when the medicine is used for an Zucker rat model with the obesity, 200-600 milligrams per day per kilogram of body weight of the kangaroo bone factors (KBF) are mixed with food and drunk, and 0.1-5 g of the green tea polyphenols (GTP) are added into 100 mL of water and drunk; and when the medicine is used for treating patients with the obesity and the related diseases, 1-5 g of the kangaroo bone factors (KBF) are taken orally at twice per day, and 0.5-2 g of the green tea polyphenols (GTP) are added into 100 mL of warm water and taken orally at twice per day. The medicine is used for preventing and treating the obesity and complications of the obesity, such as hyperlipidaemia, osteoporosis, fatty liver and diabetes.

Description

technical field [0001] The invention relates to a medicament for preventing and treating obesity and related diseases, such as metabolic syndrome, hyperlipidemia, osteoporosis, fatty liver, diabetes and the like, by combined application of saccharin and green tea polyphenols. Involved in the field of cell biology technology. Background technique [0002] With the aging of the global population and changes in human lifestyles, obesity has become one of the most important health problems for humans. The rapidly increasing incidence of associated diseases such as metabolic syndrome, hypertension, diabetes, certain cancers and osteoporosis has become a major global health burden. Over 40% of older adults in Australia are obese. At least 600,000 people in Australia have osteoporosis, mostly middle-aged and elderly, and the cost of treating osteoporosis is US$1 billion per year. This medical cost will inevitably continue to grow as the obesity and aging population increases. I...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/82A61P3/04A61P3/00A61P3/06A61P19/10A61P1/16A61P3/10A61K35/36
CPCA61K9/0095A61K35/28A61K36/82A61K2300/00
Inventor 金星亮杨五宁
Owner 南京优而生物科技发展有限公司
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