Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Naringin and levocetirizine hydrochloride pharmaceutical composition and preparation thereof

A technology of levocetirizine hydrochloride and its composition, which is applied in the field of naringin pharmaceutical composition and its preparation, can solve problems such as adverse reactions and death, and achieve good effects of relieving cough, reducing phlegm and calming asthma

Active Publication Date: 2014-12-24
SUN YAT SEN UNIV
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dextromethorphan is safe and effective in suppressing cold symptoms when used correctly in small doses, but overuse can cause death and other serious adverse effects such as brain damage, seizures, loss of consciousness and irregular heartbeats, the U.S. Food and Drug Administration said.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Naringin and levocetirizine hydrochloride pharmaceutical composition and preparation thereof
  • Naringin and levocetirizine hydrochloride pharmaceutical composition and preparation thereof
  • Naringin and levocetirizine hydrochloride pharmaceutical composition and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Inhibition of cough in guinea pigs induced by citric acid

[0017] 1. Materials

[0018] 1.1 Experimental animals Qualified Hartley guinea pigs, weighing 250-300g, male and female, were provided by the Guangdong Medical Experimental Animal Center.

[0019] 1.2 Drugs and reagents Huifei Ning; naringin is prepared according to the daily dosage of 120 mg; levocetirizine hydrochloride is prepared according to the daily dosage of 6 mg; the composition (1) group is prepared according to the daily dosage of 27.5 mg of naringin and levocetirizine hydrochloride Tirizine 1.25mg preparation; composition (2) group is prepared according to people's daily dosage of naringin 27.5mg, levocetirizine hydrochloride 12.5mg; composition (3) group is according to people's daily dosage of naringin 275mg, Cetirizine 1.25mg preparation; Composition (4) group is prepared according to human daily dosage of naringin 275mg, levocetirizine hydrochloride 12.5mg; Composition (5) group is prepared acc...

Embodiment 2

[0032] Effects on the Excretion Experiment of Phenol Red in Mice

[0033] 1. Materials

[0034] 1.1 Experimental animals Kunming mice, half male and half male, weighing 30-40 g, were provided by the Guangdong Medical Experimental Animal Center.

[0035] 1.2 Drugs and reagents: Ambroxol; naringin is prepared according to the daily dosage of 120 mg; levocetirizine hydrochloride is prepared according to the daily dosage of 6 mg; the composition (1) group is prepared according to the daily dosage of 27.5 mg of naringin and levocetirizine hydrochloride. Tirizine 1.25mg preparation; composition (2) group is prepared according to people's daily dosage of naringin 27.5mg, levocetirizine hydrochloride 12.5mg; composition (3) group is according to people's daily dosage of naringin 275mg, Cetirizine 1.25mg preparation; Composition (4) group is prepared according to human daily dosage of naringin 275mg, levocetirizine hydrochloride 12.5mg; Composition (5) group is prepared according to h...

Embodiment 3

[0048] Effect on ovalbumin-induced allergic cough (cough variant asthma)

[0049] 1. Materials

[0050] 1.1 Experimental animals: Hartley guinea pig, male, weighing 250-300 g, SPF grade, provided by Guangdong Medical Experimental Animal Center.

[0051] 1.2 Drugs and reagents Cyclophosphamide; Ovalbumin; Capsaicin; Methacholine; Aoting cough syrup (compound codeine phosphate solution); The daily dose of human is 6 mg; the composition (1) group is prepared according to the daily dose of naringin 27.5 mg and levocetirizine hydrochloride 1.25 mg; the composition (2) group is prepared according to the daily dose of naringin 27.5 mg and levocetirizine hydrochloride Cetirizine 12.5mg preparation; Composition (3) group is prepared according to the daily dosage of naringin 275mg, levocetirizine hydrochloride 1.25mg; Composition (4) group is prepared according to the daily dosage of naringin 275mg, 12.5 mg of cetirizine was prepared; the composition (5) group was prepared according t...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
weightaaaaaaaaaa
weightaaaaaaaaaa
Login to View More

Abstract

The invention relates to naringin composition and a preparation thereof. The pharmaceutical composition is characterized by comprising naringin and levocetirizine hydrochloride, wherein preferably, the naringin is in a range of 27.5-275 mg, and the levocetirizine hydrochloride is in a range of 1.25-12.5 mg; the preferable mass ratio of the naringin to the levocetirizine hydrochloride is 20:1. Tests prove that the pharmaceutical composition has good curative effects on coughs and excessive phlegm caused by various reasons and the cough variant asthma, and the efficacy of the composition is obviously superior to the efficacy of the independently-used naringin or the independently-used levocetirizine hydrochloride.

Description

technical field [0001] The invention relates to a naringin medicinal composition and preparation thereof for relieving cough, reducing phlegm and relieving asthma. Background technique [0002] Cough and expectoration are two common symptoms of respiratory system diseases, which are closely related pathologically. Generally, cough with more phlegm, and more phlegm often causes cough. Cough variant asthma refers to a special type of asthma with chronic cough as the main or only clinical manifestation. [0003] At present, the most widely used antitussive drugs in pharmaceutical drugs include codeine phosphate and dextromethorphan hydrobromide. [0004] Codeine phosphate is a central nervous system chemical widely used to relieve coughs or colds. However, in recent years, due to its serious adverse reactions, its management level has been repeatedly raised by the State Food and Drug Administration. Common adverse reactions are: psychopathy or fantasy; weak, slow or irregular...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P11/14A61P11/10A61P11/06
CPCA61K31/495A61K31/7048A61P11/06A61P11/10A61P11/14A61K2300/00A61K9/2009A61K9/2018A61K9/485A61K9/4866
Inventor 苏薇薇廖彦焦豪妍王永刚彭维李沛波
Owner SUN YAT SEN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com