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Method for reinforcing akermanite bone scaffold in selective laser sintering by utilization of nano titanium oxide

A technology of selective laser sintering and nano-titanium dioxide, which is applied in the field of three-dimensional porous magnesia feldspar ceramic bone scaffolds and nano-titanium oxide-reinforced and toughened scaffolds to achieve good biocompatibility, promote proliferation and differentiation, and improve sintering performance.

Inactive Publication Date: 2014-11-19
CENT SOUTH UNIV
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Problems solved by technology

Although the mechanical properties of AK are higher than other bioceramics, its fracture toughness is only 1.83MPam 1 / 2 , much lower than the 2-12MPam of human compact bone 1 / 2

Method used

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  • Method for reinforcing akermanite bone scaffold in selective laser sintering by utilization of nano titanium oxide
  • Method for reinforcing akermanite bone scaffold in selective laser sintering by utilization of nano titanium oxide
  • Method for reinforcing akermanite bone scaffold in selective laser sintering by utilization of nano titanium oxide

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Embodiment Construction

[0021] The specific embodiment of the present invention will be further described below in conjunction with an embodiment, but the content of the present invention is not limited thereto:

[0022] (1) Use an electronic balance to accurately weigh nano-TiO with a mass of 0.25g 2 powder and 4.75g of micron AK powder, the two powders are mixed evenly by mechanical mixing, and finally TiO 2 AK / TiO with a mass fraction of 5% 2 Composite powder.

[0023] (2) First, use the SolidWorks 3D design software to design the structure of the porous scaffold. The designed 3D porous scaffold is shown in the attached figure 1 As shown in Fig. 1, the designed 3D data model is imported into the computer for layered slice processing to obtain the cross-sectional profile information of each layer. Then, put the prepared substrate on the working platform, evenly spread a thin layer of mixed powder on the substrate, the thickness of the powder coating is 0.1-0.2μm, and the laser starts to move alo...

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Abstract

The invention relates to method for reinforcing and toughening an akermanite bone scaffold by utilization of nano titanium oxide power and for preparing a three-dimensional porous ceramic bone scaffold with a controllable micro-pore structure by utilization of the selective laser sintering technology. The problems of low toughness and poor intensity of biological ceramics and uncontrollable micro-pore structure of a prepared scaffold in a traditional porous scaffold preparation method are solved. The method is as follows: nano titanium oxide power is added into micron akermanite power, the composite power is mixed uniformly in a mechanical mixing method, and then the mixed power is placed in a selective laser sintering system and a porous akermanite bone scaffold is prepared by utilization of a rapid forming technology. The prepared porous scaffold has tough mechanical properties and an controllable micro-pore structure, and can meet the requirements of tissue-engineered bone research and application.

Description

technical field [0001] The invention belongs to the field of bone tissue engineering, in particular to a three-dimensional porous feldspar (Ca 2 MgSi 2 o 7 , Akermanite, AK) ceramic bone scaffolds, and using nano-titanium oxide (TiO 2 ) to enhance the performance of the toughened scaffold. technical background [0002] Bone scaffold is one of the three elements of bone tissue engineering and plays an important role in the process of bone repair. Bone scaffolds must have good biocompatibility, adequate mechanical properties, and a controllable degradation rate. Due to its good biocompatibility, bioactive ceramics are not only safe and non-toxic when implanted in the body, but also have certain advantages such as osteoconductivity, so they are an ideal hard tissue repair material. [0003] Because bioactive ceramic AK contains elements such as Si and Mg, it can release a certain concentration of Si ions and Mg ions after being implanted into the human body, which can effe...

Claims

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Application Information

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IPC IPC(8): C04B35/78C04B38/00C04B35/64A61L27/10A61L27/02A61L27/56
Inventor 帅词俊彭淑平冯佩
Owner CENT SOUTH UNIV
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