Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of tulathromycin oleaginous injection

A technology of telamycin and injection, which is applied in the field of telamycin oily injection, can solve the problems of slow onset of action and unfavorable treatment of animals with acute severe infection, and achieves the advantages of weakening pain response, convenient administration, and simple preparation process Effect

Active Publication Date: 2014-11-05
荷本(北京)大药厂有限公司
View PDF10 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, oily injections containing hydrophobic drugs generally have a slow onset of action, which is not conducive to the treatment of animals with acute severe infections

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of tulathromycin oleaginous injection
  • Preparation method of tulathromycin oleaginous injection
  • Preparation method of tulathromycin oleaginous injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1, prepare different concentration telamycin injections with ethyl oleate

[0034] Preparation composition: see the table below.

[0035] Numbering

[0036] Preparation method: mix formalin glycerol, benzyl benzoate, Tween-80, benzyl alcohol and 30ml ethyl oleate, add Tyramycin, stir to dissolve it, then add HCO micropowder, soybean lecithin, anti Oxygen agent (BHT0.02g, BHA0.01g, PG0.005g) and the remaining amount of ethyl oleate are homogenized with a high-speed disperser (shear type) to obtain this preparation.

Embodiment 2

[0037] Embodiment 2, prepare different concentration telamycin injections with IPM

[0038] Preparation composition: see the table below.

[0039] Numbering

[0040] Preparation method: mix formalin glycerol, benzyl benzoate, Tween-80, benzyl alcohol and 30ml IPM, add Tyramycin, stir to dissolve it, then add HCO micropowder, soybean lecithin, antioxidant ( BHT0.02g, BHA0.01g, PG0.005g) and the remaining amount of IPM are homogenized with a high-speed disperser (shear type) to obtain this preparation.

Embodiment 3

[0041] Embodiment 3, the preparation of telamycin, trimethoprim lactate compound preparation

[0042] Preparation composition: see the table below.

[0043] Numbering

[0044] Preparation method: mix glycerol formaldehyde, benzyl benzoate, Tween-80, benzyl alcohol and 30ml IPM, add Tyramycin, stir to dissolve it, then add trimethoprim lactate, HCO powder, soybean egg Phospholipids, antioxidants (BHT0.02g, BHA0.01g, PG0.005g) and the remaining amount of IPM are ground with a colloid mill and a sand mill until the solid particles are less than 5 μm to obtain the preparation.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a preparation method of a tulathromycin oleaginous injection. A cosolvent is glycerolformal / benzyl benzoate / oleaginous medium, the oleaginous medium includes ethyl oleate and isopropyl myristate, and the preparation also contains hydrogenated castor oil and soybean lecithin. The cosolvent can be utilized to prepare a compound preparation of tulathromycin and trimethoprim. The preparation has good stability, good physiological tolerance, and high load capacity, and is a sustained / rapid release oleaginous injection for animals.

Description

technical field [0001] The invention belongs to the technology for preparing veterinary drug preparations, and relates to combining telamycin with an appropriate amount of cosolvent and dissolving them in an oily medium to prepare telamycin oily injections. Background technique [0002] Tulathromycin (Tulathromycin) is a semi-synthetic antibiotic specially used for animals. It has broad antibacterial spectrum, high activity, less clinical dosage, low toxicity, low residue, no teratogenicity, and the entire treatment process can be completed with one administration, etc. Many advantages. Therefore, since Tyramycin was launched on the market, it has attracted widespread attention from all over the world. The commercially available telamycin product is an injection, which is a water-miscible solution type injection. Most of the technologies disclosed in the patents use organic solvent / water co-solvent and acidic conditions to prepare telamycin injection (CN1429232A, CN1014224...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/10A61K31/7052A61K47/44A61K47/34A61K47/22A61K47/14A61P31/04A61K47/26
Inventor 王玉万潘贞德戴晓曦任雅楠沈力
Owner 荷本(北京)大药厂有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com