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Extraction process of ursolic acid in dogwood kernels

A technology of cornus kernel and extraction process, which is applied in the field of extraction technology of ursolic acid in cornus kernel, can solve the problems of neglecting the development value of cornus kernel, consumption of solvent and time, solvent residue, etc., and achieves increased cell fragility and long processing time. , the effect of low production cost

Active Publication Date: 2014-10-01
江学忠
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The article "Extraction and Content Determination of Ursolic Acid in Cornus officinalis" published by Zhao Yucong showed that the ultrasonic extraction method is simple, time-consuming, without heating, and the extraction is the most complete, but the process still has the following defects: Cornus officinalis and cornus pits were discarded, ignoring the development value of Cornus officinalis pits, resulting in a waste of resources; ②Soaking in 40ml of absolute ethanol for 12h before ultrasonic extraction, and then using ultrasonic vibration for 30min, still consumes solvent and time, easy cause solvent residue

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] ① Raw material pretreatment: select 10kg of high-quality dogwood kernels without mold (the content of ursolic acid is about 15g) as raw materials, rinse with clean water to remove the soil and sand outside the dogwood kernels, and put the rinsed dogwood kernels into hanging In the bucket, control the moisture;

[0042] ②Roasting: put the dogwood cores that have been dehydrated from the outside into a controllable drying oven at 50°C, and dry them for 1.0 hours. During the drying process, keep turning the dogwood cores to make them evenly heated and prevent them from being burnt;

[0043] ③Primary crushing: crush the baked dogwood core for the first time, and crush it into particles with a diameter of 80 mesh;

[0044] ④ Freezing: Grind the dogwood core powder into particles with a diameter of 80 meshes, put it into a freezer at a temperature of 0°C, and freeze for 1 hour;

[0045] ⑤Secondary crushing: crush the frozen dogwood core powder into 180 meshes;

[0046]⑥ Soa...

Embodiment 2

[0053] The extraction process of ursolic acid in the Cornus officinalis core of the present invention, the steps are as follows:

[0054] ① Raw material pretreatment: select 10kg of high-quality dogwood kernels without mold (the content of ursolic acid is about 15g) as raw materials, rinse with clean water to remove the soil and sand outside the dogwood kernels, and put the rinsed dogwood kernels into hanging In the bucket, control the moisture;

[0055] ②Roasting: put the dogwood cores that have been dehydrated from the outside into a controllable drying oven at 53°C, and dry them for 1.0 hours. During the drying process, keep turning the dogwood cores so that the cornel cores are evenly heated to prevent burning;

[0056] ③Primary crushing: crush the baked dogwood core for the first time, and crush it into particles with a diameter of 85 mesh;

[0057] ④ Freezing: Grind the dogwood core powder into particles with a diameter of 85 mesh, put it into a freezer at -2°C, and fre...

Embodiment 3

[0066] The extraction process of ursolic acid in the Cornus officinalis core of the present invention, the steps are as follows:

[0067] ① Raw material pretreatment: select 10kg of high-quality dogwood kernels without mold (the content of ursolic acid is about 15g) as raw materials, rinse with clean water to remove the soil and sand outside the dogwood kernels, and put the rinsed dogwood kernels into hanging In the bucket, control the moisture;

[0068] ②Roasting: put the dogwood cores that have been dehydrated from the outside into a controllable drying oven at 56°C, and dry them for 1.0 hours. During the drying process, keep turning the dogwood cores so that the cornel cores are evenly heated to prevent burning;

[0069] ③Primary crushing: crush the baked dogwood core for the first time, and crush it into particles with a diameter of 90 mesh;

[0070] ④ Freezing: Crush cornel kernel powder into particles with a diameter of 90 meshes, put them into a freezer at -4°C, and fr...

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Abstract

The invention discloses an extraction process of ursolic acid in dogwood kernels. In the extraction process, the dogwood kernels are adopted as raw materials, and a qualified product of ursolic acid is obtained by the steps of raw material pretreatment, baking, primary grinding, freezing, secondary grinding, soaking, ultrasonic treatment, distillation, low-temperature evaporation and third grinding. The production period of the process is short, the yield of ursolic acid is high, the product purity is high, the purity of the obtained ursolic acid product can reach 91.37-93.03%, and the recovery rate of ursolic acid reaches 90.73-91.87%, so that a new means is provided for preparing ursolic acid and developing dogwood kernel resources.

Description

technical field [0001] The invention belongs to the technical field of preparing ursolic acid from cornus officinalis, and in particular relates to a process for extracting ursolic acid from cornus officinalis. Background technique [0002] Modern scientific research has found that ursolic acid contained in plants is a triterpenoid compound, which is widely used in medicine. Can be used as: liver protection, anti-hepatitis, anti-oxidation, anti-bacterial, anti-inflammatory and anti-viral effects, blood fat-lowering, anti-atherosclerosis, blood sugar-lowering and anti-ulcer effects, HIV-inhibiting, calming And stable effect, has the effect of enhancing immune function. Because ursolic acid is an active ingredient in plants, it is widely used in medicine and medical science. It is proved that ursolic acid is a broad-spectrum antibiotic, so it was included in the 2002 "863" plan by the state. [0003] When making the traditional Chinese medicine Cornus officinalis, the "co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00
Inventor 江学忠郭武华
Owner 江学忠
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