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Traditional Chinese medicine extract for treating osteoarthritis and preparation method thereof

A technology of osteoarthritis and extracts, applied in the field of traditional Chinese medicine extracts and preparations for the treatment of osteoarthritis, can solve problems such as unsatisfactory treatment effects, achieve significant social and economic benefits, broad application prospects, and significant curative effects Effect

Active Publication Date: 2014-09-03
GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Chinese medicine scholars have conducted a series of experimental studies on the treatment of OA with traditional Chinese medicine by using the results of modern clinical pathology and biochemical pharmacology research, and initially revealed the mechanism of the efficacy of traditional Chinese medicine in treating this disease, the therapeutic effect is still unsatisfactory.

Method used

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  • Traditional Chinese medicine extract for treating osteoarthritis and preparation method thereof
  • Traditional Chinese medicine extract for treating osteoarthritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Preparation of Chinese medicinal extracts for the treatment of osteoarthritis

[0025] (1) Law One

[0026] Take by weighing 25Kg of Sangjisi, 25Kg of Chuanduan, 15Kg of Qiannianjian, 15Kg of Pinus tabulaeformis, 15Kg of Drynaria fortunei, 10Kg of ground beetle, 15Kg of Achyranthes bidentata, and 25Kg of Spatholobus Spatholobus.

[0027] Mix the two medicines of Chinese pine knot and Qiannianjian, add water in an amount 8 times the total mass of the two medicines, add them into a multifunctional extraction tank, and extract for 5 hours to obtain the water extract 1 and the oil-water mixture. The oil-water mixture is separated by ultrafiltration using an organic membrane. The membrane material is a modified polysulfone membrane with a molecular weight cut-off of 120,000 Daltons, an operating pressure of 0.10 MPa, and a system temperature of 60°C. Take the ultrafiltration retentate (340mL) as the volatile oil, and the ultrafiltration permeate as the water extra...

Embodiment 2

[0036] Embodiment two clinical research

[0037] Select 40 patients with knee osteoarthritis, including 20 cases in the treatment group and 20 cases in the control group. Clinically observed the changes of laboratory indicators such as WOMAC index of main symptoms and signs, TCM symptoms and erythrocyte sedimentation rate in the two groups before and after treatment.

[0038] 1. Treatment method

[0039] (1) Treatment group: Gubi granule (prepared in Example 1 (1)), twice a day, 2 packs each time. If the joint pain is obvious, short-term application (3-5 days) of meloxicam tablets 7.5 mg can be taken as appropriate, 1 tablet each time, orally once a day.

[0040] (2) Control group: mainly used non-steroidal anti-inflammatory drugs, meloxicam tablets 7.5 mg, 1 tablet each time, orally once a day. If economic conditions permit, drugs to improve cartilage metabolism (glucosamine sulfate 0.25g-0.5g, orally 3 times a day) will be administered at the same time.

[0041] (3) Cour...

Embodiment 3

[0069] Example 3 Comparison of anti-inflammatory pharmacological experiments between the extract of the present invention and the extract obtained by other processes

[0070] 1 Materials and Instruments

[0071] 1.1 Experimental animals

[0072] 220 adult SPF-grade ICR mice, half male and half female, weighing (25±2) g (Nanjing Qinglongshan Animal Breeding Farm, license number: SCXK (Shanghai) 2013-0012) half were used for the mouse ear swelling experiment, half Used in mouse toe swelling experiment. The mice were adaptively fed for 1 week, and the picric acid markers were divided into 11 groups: normal saline group, aspirin group, high-dose decoction group (A1), medium-dose decoction group (A2), and low-dose decoction group (A3), high-dose group of ethanol precipitation method (B1), medium-dose group of ethanol precipitation method (B2), low-dose group of ethanol precipitation method (B3), high-dose group of Gubi solution (C1), middle-dose group of Gubi solution Dose group...

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Abstract

The invention provides a traditional Chinese medicine extract for treating osteoarthritis and a preparation method thereof, relating to the technical field of traditional Chinese medicines. The extract comprises volatile oil and a water extracting solution, wherein the volatile oil is extracted from obscured homalomenarhizome and pinus tabulaeformis carr; the water extracting solution is extracted from Chinese taxillus twig, dipsacus root, fortune's drynaria rhizome, ground beetle, radix achyranthis bidentatae and suberect spatholobus stem. The invention also provides a preparation method of the extract. The method comprises the steps of extracting the volatile oil from obscured homalomenarhizome and pinus tabulaeformis carr; extracting Chinese taxillus twig, dipsacus root, fortune's drynaria rhizome, ground beetle, radix achyranthis bidentatae and suberect spatholobus stem by water to obtain the water extracting solution. The extract provided by the invention is significant in curative effect, and has the clinical cure rate of 15%, the total significant efficiency of 60%, and the total effective rate of 100%. The preparation method provided by the invention is used for fully extracting the volatile oil from obscured homalomenarhizome and pinus tabulaeformis carr, and can be used for effectively removing impurities in medicinal materials which have inhibition effects on therapeutic effects, significantly improving anti-inflammatory effects in animal experiments, and significantly improving the cure rate and significant efficiency in clinical trials.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine pharmacy, in particular to a traditional Chinese medicine extract for treating osteoarthritis and a preparation method thereof. Background technique [0002] Osteoarthritis (OA) is a clinically common degenerative joint disease and the most common type of bone and joint disease. A refractory disease of unknown etiology {Altman RD. The classification of osteoarthritis, Rheumatic Supply, 1995, 43: 42-3}. OA belongs to the category of "gubi" in traditional Chinese medicine. It is currently believed that its main pathogenesis lies in kidney deficiency and blood stasis. Its fundamental factor comes from the kidney deficiency caused by inner aging, deficiency of kidney qi, deficiency of essence and blood, unable to moisten and nourish muscles and bones, resulting in "bone impediment". Surgical treatment is relatively painful, and the existing western medicine mainly aims at improv...

Claims

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Application Information

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IPC IPC(8): A61K36/888A61K47/48A61P19/02A61P29/00A61K35/64A61K47/69
Inventor 朱华旭周学平郭立玮周仲瑛周玲玲宗杰
Owner GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY
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