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Granular molding preparation method for Chinese medicinal herbs

A Chinese medicinal material, granulation technology, applied in the directions of plant raw materials, plant/algae/fungus/moss ingredients, pharmaceutical formulations, etc., can solve the problems of insufficient improvement of extraction efficiency, inability to achieve homogenization, and low bioavailability, etc. Achieve the effect of avoiding the waste of medicinal materials, improving the utilization rate of medicinal materials, and avoiding the effect of moisture failure.

Active Publication Date: 2014-08-20
江苏华冠生物技术股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is difficult to prepare finer medicinal powder with conventional equipment for crushing Chinese herbal medicines in my country
The common pulverization technology usually has the following disadvantages: 1. The bioavailability is not high, and most of them use cells as the basic structural unit
Second, it is crushed and cannot be homogenized
Third, it is not possible to fully improve the extraction efficiency
Fourth, the utilization rate of medicinal materials is low, and a lot of medicinal materials are wasted when used
In the general granulation process, the active ingredients of many medicinal materials are not well released and completely preserved, resulting in waste

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of cassia seed granule comprises the following steps:

[0026] 1. Select clean medicinal materials and carry out the process of cleaning the outer packaging.

[0027] 2. Depending on the medicinal material of cassia zijing, control the temperature of the crushing room at 20-23°C and the relative humidity below 45%, and use a pre-installed 100-mesh sieve universal grinder for preliminary crushing. The obtained coarse powder is immediately packed into a plastic bag, tied tightly, and placed in a damp place. , that is, coarse powder.

[0028] 3. Add the medicinal materials obtained above into an ultrafine wall-breaking pulverizer for pulverization, and then pulverize them to a size above 325 mesh to obtain cassia seed superfine powder. Control the temperature of the crushing room at 20-23°C and the relative humidity below 45%.

[0029] 4. Take the superfine powder of cassia seeds obtained above, put it directly into the dry granulator, add auxiliary mater...

Embodiment 2

[0042] The preparation of cassia seed granule comprises the following steps:

[0043] 1. Select clean medicinal materials and carry out the process of cleaning the outer packaging.

[0044] 2. Depending on the medicinal material of cassia, the temperature of the crushing room should be controlled at 20-23°C, and the relative humidity should be below 45%. Preliminarily pulverize with a pre-installed 100-mesh sieve universal grinder, and immediately pack the obtained coarse powder into a plastic bag, tie the bag tightly, and place it to be damp to obtain coarse powder.

[0045] 3. Pretreatment: spread the coarse powder on the tray and freeze in the freezer; thaw the frozen coarse powder and put it into a centrifuge for processing. The thickness of the coarse powder on the tray is 1-5mm; The environment in the freezer is controlled at minus 18°C ​​- minus 22°C, the air velocity is 1m / s, the freezing time is 22-34min; the thawing time is 20-27min, the temperature in the thawing r...

Embodiment 3

[0061] Prepare yam granules, comprising the following steps:

[0062] 1. Select clean medicinal materials and carry out the process of cleaning the outer packaging.

[0063] 2. Take the pure medicinal material of yam, control the temperature of the crushing room at 20-23°C, and the relative humidity below 45%, and use a pre-installed 100-mesh sieve universal grinder for preliminary crushing. The coarse powder obtained is immediately packed into a plastic bag, tied tightly, and placed to be damp. , that is, coarse powder.

[0064] 3. Pretreatment: spread the coarse powder on the tray for freezing in the freezer; thaw the frozen coarse powder and put it in a centrifuge for processing. The thickness of the coarse powder on the tray is 1-5mm. The environment in the freezer is controlled at minus 18°C ​​- minus 22°C, the air flow rate is 1m / s, the freezing time is 22-25min; the thawing time is 20-25min, the temperature in the thawing room is 20-30°C, and the relative humidity is 5...

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Abstract

The invention discloses a granular molding preparation method for Chinese medicinal herbs. The method comprises the following steps: A, adoption of a herbal material: a step of selecting and slicing the herbal material and drying the herbal material so as to obtain a clean herbal material; B, crushing: a step of selecting the clean herbal material and preliminarily crushing the clean herbal material by using a universal pulverizer with a crushing degree range of 10 to 120 meshes so as to obtain coarse powder with a size of 80 to 95 meshes; C, ultramicro wall-breaking crushing; D, dry granulation: a step of placing obtained Chinese herbal powder into a dry granulator, adding adjuvant, preparing a blank tablet with a diameter of 20 to 25 mm in virtue of binding force among particles under the action of compression force and crushing the tablet into particles with a size of 50 to 100 meshes; E, sterilization; and F, split charging and packaging. With the method, active substances in the herbal material can be fully released and retained, the wall breaking rate of the herbal material is high, and waste is avoided.

Description

technical field [0001] The invention relates to a preparation method, in particular to a preparation method for granulation and molding of Chinese herbal medicinal materials. Background technique [0002] According to Chinese Pharmacopoeia, the finest classification of traditional Chinese medicine powder is "very fine powder", which means that it can pass through No. Value 75±4.1μm) not less than 95% powder. It is difficult to prepare finer medicinal powder with the conventional equipment for pulverizing Chinese herbal medicines in my country. The common crushing technology usually has the following disadvantages: First, the bioavailability is not high, and most of them use cells as the basic structural unit. Second, it is pulverized and cannot be homogenized. Three, can not fully improve extraction efficiency. Fourth, the utilization rate of medicinal materials is low, and a lot of waste is caused when medicinal materials are used. In the general granulation process, t...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K36/482A61K36/8945A61K36/488
Inventor 王邦洲刘勇方红英
Owner 江苏华冠生物技术股份有限公司
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