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Carbon nanotube surface molecularly imprinted polymer as well as preparation method and application thereof

A technology of surface molecular imprinting and carbon nanotubes, which is applied in the direction of material electrochemical variables, can solve problems such as unfavorable enterprise and social development, a large amount of pollutants, and environmental hazards, so as to improve conductivity and current response speed, take a long time, highly sensitive effect

Active Publication Date: 2014-08-06
JIAXING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Similar to the problems existing in the prior art for surface graft modification of multi-walled carbon nanotubes, the disadvantage of this preparation method is that step (1) directly grafts alkenyl groups on the surface of multi-walled carbon nanotubes, requiring Large amounts of organic solvents such as concentrated HNO are used 3 , concentrated H 2 SO 4 , SOCl 2 , DMF, pyridine, etc., not only the operation process is dangerous, but also produces a large amount of pollutants, which seriously endangers the environment and is not conducive to the development of enterprises and society

Method used

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  • Carbon nanotube surface molecularly imprinted polymer as well as preparation method and application thereof
  • Carbon nanotube surface molecularly imprinted polymer as well as preparation method and application thereof
  • Carbon nanotube surface molecularly imprinted polymer as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Example 1 Preparation of Molecularly Imprinted Polymer on Carbon Nanotube Surface

[0086] 1. Preparation of molecularly imprinted polymers on the surface of carbon nanotubes

[0087] The preparation process of molecularly imprinted polymers on the surface of carbon nanotubes is as follows: figure 1 As shown, it specifically includes the following steps:

[0088] (1) Purification of carboxylated multi-walled carbon nanotubes

[0089] In order to remove a small amount of amorphous carbon and metal impurities in carboxylated multi-walled carbon nanotubes (CNTs), the CNTs-COOH is purified. The purification method is:

[0090] In a 100 mL round bottom flask, 40.0 mL H 2 O, 9.28mL HNO 3 Mix well, then add 2.0g CNTs-COOH, and reflux at 85°C for 48h. After filtering, the CNTs-COOH was washed with deionized water to neutrality, and dried in vacuum at 60°C for 12 hours, and set aside.

[0091] (2) Synthesis of silica-coated multi-walled carbon nanotubes

[0092] Weigh 250...

Embodiment 2

[0112] The preparation of embodiment 2 electrochemical sensor

[0113] 1. Preparation of electrochemical sensors

[0114] (1) The naked glassy carbon electrode (GCE, diameter 3mm) is sequentially coated with 0.3μm, 0.05μm Al 2 o 3 Powder suspension polishing treatment, and then with absolute ethanol, ddH 2 O ultrasonic (53KHz) cleaning, each 10min, finally place room temperature to dry, stand-by;

[0115] (2) Take 20.0mg γ-MAPS / CNTsSiO 2 -MIPs were added to 1mL of 0.5% chitosan solution, 53KHz ultrasonic 60min, so that the two were evenly mixed to obtain a mixed solution; then take 5.0 μL of the mixed solution and apply it on the surface of the bare glassy carbon electrode treated in step (1), Dry at room temperature for 6 hours to obtain the imprinted electrode (γ-MAPS / CNTsSiO 2 -MIPs / GCE);

[0116](3) Use the imprinted electrode of step (2) as the working electrode, the saturated calomel electrode as the reference electrode, the platinum electrode as the counter electr...

Embodiment 3

[0147] Embodiment 3 The detection of the actual sample by the electrochemical sensor

[0148] In order to investigate the detection feasibility of the electrochemical sensor of the present invention, the actual sample rutin tablets were tested.

[0149]First, use a mortar to grind the commercially available rutin tablets, and then use ethanol to ultrasonically dissolve it completely to obtain a rutin tablet solution; take an appropriate amount of the upper layer of the rutin tablet solution with PBS buffer solution (pH4.5) Dilute to 5 mL. Then, the imprinted electrode was immersed in the above diluent, stirred and adsorbed for 7 minutes, and DPV detection was performed. Each sample was tested 5 times in parallel, and the average value was taken. The detection results are shown in Table 2.

[0150] Table 2

[0151]

[0152] It can be seen from Table 2 that the detection value of the imprinted electrode is basically consistent with the marked value, the recovery rate is 99....

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Abstract

The invention discloses a carbon nanotube surface molecularly imprinted polymer as well as a preparation method and application thereof. The preparation method comprises the following steps: taking carboxylated multi-walled carbon nanotubes, synthesizing silicon dioxide-coated multi-walled carbon nanotubes by a sol-gel method; modifying the silicon dioxide-coated multi-walled carbon nanotubes by using a silane coupling agent to obtain alkenylated multi-walled carbon nanotubes; mixing the alkenylated multi-walled carbon nanotubes, Rutin and acrylamide under the protection of inert gas, and performing radical polymerization under the existence of an initiator and a cross-linking agent to prepare the carbon nanotube surface molecularly imprinted polymer. An electrochemical sensor manufactured from the carbon nanotube surface molecularly imprinted polymer has the characteristics of good conductivity, high selectivity, fast response, high sensitivity and the like to the Rutin and can quickly and effectively detect Rutin content of a sample.

Description

technical field [0001] The invention belongs to the technical field of molecularly imprinted polymers, in particular to a molecularly imprinted polymer on the surface of carbon nanotubes and its preparation method and application. Background technique [0002] Rutin, also known as vitamin P, as a drug, rutin can reduce capillary permeability and fragility, maintain and restore the normal elasticity of capillaries, it is also commonly used in hypertensive cerebral hemorrhage, retinal hemorrhage, acute hemorrhagic nephritis and recurrent Adjuvant treatment of epistaxis, etc. It is necessary to establish a fast, accurate, sensitive and convenient new method for rutin drug detection for quality control and clinical analysis. [0003] At present, the main methods for detecting rutin include high performance liquid chromatography, capillary electrophoresis, fluorescence spectroscopy and electrochemical sensor method. However, methods such as high performance liquid chromatograph...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F292/00C08F220/56C08F220/06C08F226/06C08J9/26G01N27/30
Inventor 李蕾曾延波汤传贵李倩张剑曹红刘海清尹争志
Owner JIAXING UNIV
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