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Medicament for preventing and treating disuse osteoporosis and preparation method thereof

A technology of medicine and raw material medicine, applied in the field of medicine and its preparation for the prevention and treatment of disuse osteoporosis, which can solve the problems of hidden, unsatisfactory and insufficient understanding of the onset of disuse osteoporosis, etc. Achieve the effect of promoting the optimization of biomechanical indicators, improving bone formation, and improving structure and function

Inactive Publication Date: 2014-07-16
TAISHAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the existing traditional Chinese medicine has a certain curative effect in the treatment of osteoporosis, but it is not ideal.
Due to the insidious onset of disuse osteoporosis, insufficient understanding has been obtained, so there are few prescriptions for the treatment of disuse osteoporosis

Method used

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  • Medicament for preventing and treating disuse osteoporosis and preparation method thereof
  • Medicament for preventing and treating disuse osteoporosis and preparation method thereof
  • Medicament for preventing and treating disuse osteoporosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0019] Embodiment: Yiqi Bushen Huoxue prescription and Bushen Huoxue recipe and preparation method thereof

[0020] Weigh 60g astragalus, 15g heterophylla, 24g rehmannia, 15g Dipsacus, 15g mulberry, 12g angelica, 9g peach kernel, 12g safflower, 30g achyranthes bidentata, 12g drynaria, 6g licorice; add 5 times the volume of medicinal materials in water, soak 2h, decoct for 45 minutes for the first time, pour out the decoction, add appropriate amount of water, decoct for 40 minutes again, combine the two decoctions, concentrate to a certain concentration (the dose is 480mg of crude drug / ml), that is, it is called Yiqi Kidney-tonifying and blood-activating formula.

[0021] According to the above method, weigh 24g of Rehmannia glutinosa, 15g of Dipsacus, 15g of Sangji, 12g of Angelica, 9g of peach kernel, 12g of safflower, 30g of Achyranthes bidentata, 12g of Drynaria fortunei, and 6g of licorice. Add water 5 times the volume of the medicinal materials, soak for 2 hours, decoct ...

experiment example 1

[0030] Experimental Example 1: Effects of Yiqi Bushen Huoxue Decoction and Bushen Huoxue Decoction on Bone Density of Disuse Osteoporosis Rats

[0031]1 Determination of bone mineral density (BMD) and bone mineral content (BMC)

[0032] The rats in each experimental group were anesthetized by intraperitoneal injection with 1% sodium pentobarbital at a concentration of 40 mg / kg, and then killed by puncture and bloodletting at the carotid artery of each rat with a syringe. The rats were placed on the examination bed of the bone densitometer, under the probe of the bone densitometer, and the animal whole body bone densitometry software was selected to scan the whole body of the rats under test.

[0033] Select slow scan mode, 76Kv voltage, 150μA. In the measurement mode option of the dual-energy X-ray bone density analyzer, select the system default standard measurement to analyze the bone density of the whole body, femur and spine of the rats in each experimental group, and acc...

experiment example 2

[0067] Experimental Example 2: Effects of Yiqi Bushen Huoxue Decoction and Bushen Huoxue Decoction on Biochemical Indexes of Bone Transformation in Disuse Osteoporosis Rats

[0068] 1 Experimental materials: In addition: serum alkaline phosphatase detection kit, Shanghai Fosun Changzheng Medical Technology Co., Ltd.; urine DPD detection kit, American QUIDEL company; bone-derived alkaline phosphatase BAP kit, Beijing Jinyu High Technology Technology Co., Ltd.; Rat BGP Radioimmunoassay Kit, Great Wall Biological Co., Ltd.; Rat Bone Morphogenetic Protein-2 (BMP-2); ELISA Quantitative Detection Kit, Wuhan Boster Bioengineering Co., Ltd.

[0069] 2 Experimental methods

[0070] 2.1 Establishment of rat disuse osteoporosis model: Grouping of experimental rats: 50 SD rats were randomly divided into 5 groups by block random method: Yiqi Bushen Huoxue Prescription Group, Bushen Huoxue Prescription Group, Model Group , blank control group, and Caltrate group, used to determine the bone...

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Abstract

The invention discloses a medicament for preventing and treating disuse osteoporosis and a preparation method thereof. The medicament is prepared from the following raw medicaments: prepared rhizome of rehmannia, teasel root, mistletoe, angelica, peach seeds, safflower, achyranthes root, drynaria rhizome and licorice, which form a kidney tonifying and blood activating formula. The medicament can further comprise astragalus root and pseudostellaria heterophylla, so as to obtain a qi tonifying, kidney tonifying and blood activating formula. The medicament can improve the bone metabolism of disuse osteoporosis rats, reduce the content of ALP (alkaline phosphatase) or BAP (bone alkaline phosphatase), obviously improve the content of Ca, BGP (bone calcium protein), BMP-2 (bone morphogenetic protein 2), HOP (urinary hydroxyproline), HOP / Cr and TRAP (tartrate-resistant acid phosphatase), reduce the content of TNF-alpha (tumor necrosis factor-alpha), IL-4 (interleukin-4) and IL-6 (interleukin-6), promote the proliferation of mesenchymal stem cells, effectively improve the activity of BALP (bone alkaline phosphatase), increase bone formation, benefit to treating the disuse osteoporosis, obviously promote the proliferation of osteoclasts, improve bone formation, reduce bone absorption and promote the increase of bone mass, and has a certain prevention effect on the disuse osteoporosis.

Description

technical field [0001] The invention relates to a medicine for preventing and treating disuse osteoporosis and a preparation method thereof. Background technique [0002] Disuse osteoporosis (Disuse Osteoporosis DOP) is a local or systemic osteoporosis phenomenon that occurs due to the reduction of mechanical stress on bones, resulting in local or systemic bone loss and bone quality reduction. In clinical practice, DOP may occur in patients who must stay in bed for a long time due to various diseases, patients with limited exercise capacity and surgical immobilization, as well as astronauts. When the normal load of the bone weakens or disappears due to immobilization, bone remodeling corresponding to the external load occurs, resulting in a decrease in mechanical strength and bone atrophy. Studies have shown that when the patient is in bed for 4 weeks, the bone mass of the cancellous bone of the iliac crest begins to decline, and the bone mass declines by about 33% when the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61P19/10
Inventor 于学美崔西泉孙建翠王荣梅吴雅迪董军
Owner TAISHAN MEDICAL UNIV
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