A nasal spray for treating allergic rhinitis

A technology of allergic rhinitis and nasal spray, which is applied in the field of medicine, can solve the problems of capillary atrophy and ineffective treatment, and achieve the effects of promoting absorption, ensuring pH value, and overcoming side effects

Active Publication Date: 2015-09-02
SHANDONG TIANSHUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the limitations of the excipients used in nasal drops, its therapeutic effect is not obvious, and it also causes serious side effects such as capillary atrophy inside the nasal cavity

Method used

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  • A nasal spray for treating allergic rhinitis
  • A nasal spray for treating allergic rhinitis
  • A nasal spray for treating allergic rhinitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Naphthalene Naphthalene Nasal Spray

[0026] Prescription: 1000 sticks

[0027]

[0028] Preparation process: Take the prescribed amount of sodium cromoglycate, naphazoline hydrochloride, chlorpheniramine maleate, polyethylene glycol (PEG) lauryl hydroxystearate, and sorbitol in an appropriate amount of containers, add purified water , stir at room temperature, after the above materials are dissolved, add purified water to the full amount, filter through a 0.22 μm microporous membrane to obtain a chromagannaphthylamine solution, the pH value is 6.4, and pack under the condition of avoiding bacteria In qualified spray bottles, inspected and packaged.

Embodiment 2

[0029] Example 2 Naphthalene Naphthalene Nasal Spray

[0030] Prescription: 1000 sticks

[0031]

[0032] Preparation process: Take the prescribed amount of sodium cromoglycate, naphazoline hydrochloride, chlorpheniramine maleate, polyethylene glycol (PEG) lauryl hydroxystearate in an appropriate amount of container, add purified water, and place at room temperature Stir at a lower temperature, after the above materials are dissolved, add sorbitol and stir, finally add purified water to the full amount, filter with a 0.22 μm microporous membrane, and obtain a sarcogannaphthylamine solution with a pH value of 5.7, which is suitable for preventing bacteria Packed in qualified spray bottles under certain conditions, inspected and packaged.

Embodiment 3

[0033] Embodiment 3 Naphthalene Naphthalene Nasal Spray

[0034] Prescription: 1000 sticks

[0035]

[0036] Preparation process: Take the prescribed amount of sodium cromoglycate, naphazoline hydrochloride, chlorpheniramine maleate, polyethylene glycol (PEG) lauryl hydroxystearate, and sorbitol in an appropriate amount of containers, add purified water , stir at room temperature, after the above materials are dissolved, add purified water to the full amount, filter through a 0.22 μm microporous membrane to obtain a chromagannaphthylamine solution, the pH value is 5.6, and pack under the condition of avoiding bacteria In qualified spray bottles, inspected and packaged.

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PUM

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Abstract

The invention provides nasal spray for treating allergic rhinitis. The nasal spray comprises cromolyn sodium, naphazoline hydrochloride, chlorpheniramine maleate and a pharmaceutically acceptable excipient selected from a buffering agent, an osmotic pressure regulator, an absorption enhancer, a pH regulator and the like. Active ingredients in the preparation can take effect rapidly by being rapidly adsorbed through mucosa of nasal cavity. The nasal spray has the advantages of high bioavailability, high compliance, convenience in carrying and use, and the like.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating allergic rhinitis, in particular to a nasal spray for treating allergic rhinitis, which belongs to the field of medicine. Background technique [0002] Rhinitis is a common and frequently-occurring disease in the current market, among which allergic rhinitis is more common. Allergic rhinitis, also known as allergic rhinitis, is a local symptom of systemic allergic reaction occurring in the nasal mucosa. factors. Because the time of exposure to allergens and the patient's body reaction are different, it is clinically divided into perennial allergic rhinitis and seasonal allergic rhinitis. The former can occur at any time; the latter occurs in allergen seasons, such as spring and autumn when there is pollen. When the disease breaks out, symptoms such as nasal congestion, runny nose, hyposmia, and slurred speech often occur. These symptoms often affect normal rest and sleep, and hinder ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4402A61K9/12A61P37/08A61P11/02A61K31/4174A61K31/352
Inventor 徐宜铁林航尹睿梁霞李本超杨金岭
Owner SHANDONG TIANSHUN PHARMA
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