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Alpha-type zinc- phthalocyanine nanowires having enhanced water solubility and water dispersibility, composite of an alpha-type zinc- phthalocyanine nanowire/phenothiazine, and method for preparing same

一种酞菁纳米线、水溶解度的技术，应用在纳米结构制造、用于传感的纳米技术、含有效成分的医用配制品等方向，能够解决不具有荧光、很难引用成像系统等问题，达到简化引用、优秀光治疗效果的效果

Active Publication Date: 2014-05-28
POSTECH ACAD IND FOUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among various photosensitizers, zinc-phthalocyanine nanowires can absorb long-wavelength light and generate more reactive oxygen species through the presence of zinc atoms.

Method used

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  • Alpha-type zinc- phthalocyanine nanowires having enhanced water solubility and water dispersibility, composite of an alpha-type zinc- phthalocyanine nanowire/phenothiazine, and method for preparing same
  • Alpha-type zinc- phthalocyanine nanowires having enhanced water solubility and water dispersibility, composite of an alpha-type zinc- phthalocyanine nanowire/phenothiazine, and method for preparing same
  • Alpha-type zinc- phthalocyanine nanowires having enhanced water solubility and water dispersibility, composite of an alpha-type zinc- phthalocyanine nanowire/phenothiazine, and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Example 1: Preparation of alpha (α)-form zinc-phthalocyanine nanowires

[0090] ZnPc powder was used as a precursor and the alpha (α)-form of ZnPc was prepared by a solid-vapor transport reaction known as vapor-condensation-recrystallization (VCR) Nanowires.

[0091] Specifically, ZnPc powder (0.05 g, Sigma-Aldrich Company) was put into a ceramic boat located at the center of a quartz tube (quartz tube) in an electric heating furnace system. Prior to the reaction, the quartz tube was purged with Ar gas at a flow rate of 800 sccm for 5 minutes to remove clogged surrounding air. Continue to discharge Ar gas and heat to 550°C for distillation. A Si(100) substrate (wafer) (WRS material) was placed at the end (downstream) of the above-mentioned electric heating furnace.

[0092] During the reaction, under the temperature condition of 550°C, the ZnPc powder located in the central tube of the heating furnace was subjected to distillation treatment, and Ar gas was used to push...

experiment example 1

[0093] Experimental example 1: Characteristic analysis of alpha (α)-form zinc-phthalocyanine nanowires

[0094] In order to confirm the form, chemical structural elements, and diffraction patterns of the alpha (α)-form ZnPc nanowires prepared in Example 1 above, the following experiments were performed.

[0095] 1. SEM measurement

[0096] For scanning electron microscopy (SEM, JSM-7410F, JEOL) measurements, Au was sputtered on the alpha (α)-form ZnPc nanowires prepared in Example 1 above. The SEM images obtained by this method are shown in Fig. lb.

[0097] As shown in Figure 1b, the alpha (α)-form ZnPc nanowires have a diameter of about 50–100 nm and a length of about 1–10 μm.

[0098] 2. XRD measurement

[0099] For the crystalline structure of the Alpha (α)-form ZnPc nanowires prepared in Example 1 above, X-ray powder diffraction (X-ray powder diffraction, XRD, D / MAX- 2500 / PC, RIGAKU), and were measured using high-resolution transmission electron microscopy (HR-TEM, JE...

experiment example 2

[0122] Experimental Example 2: Water Solubility Test of Alpha (α)-Form ZnPc Nanowires

[0123] 1. Formal TEM and stability observation of alpha (α)-form ZnPc nanowire solution

[0124]1 mg of the alpha (α)-form ZnPc nanowires collected from the Si substrate was added to 5 mL of water, and then performed at various times (5 minutes, 40 minutes) using a bathsonicator (bathsonicator; UC-10, JEIOTECH). Ultrasonic treatment finally prepares the alpha (α)-form ZnPc nanowire solution. The final obtained solution was transferred to a UV-vis spectrophotometer (Agilent 8453 spectrophotometer) for optical absorbance measurement. The concentration of the alpha (α)-form ZnPc nanowire solution was determined by measuring the absorbance at 219nm, and the absorbance of the serially diluted treatment solution was measured at 219nm to formulate a measurement curve.

[0125] Form observation results and TEM images of alpha (α)-form ZnPc nanowire solutions such as Figure 8 , and its stability...

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Abstract

The present invention relates to alpha-type zinc- phthalocyanine nanowires (ZnPc NWs) having enhanced water solubility and water dispersibility, to a composite of an alpha-type zinc-phthalocyanine nanowire / phenothiazine, to a method for preparing same, and to a photosensitizer including same or a pharmaceutical composition including same for preventing or treating cancers. Since the alpha-type zinc-phthalocyanine nanowires or the composite of alpha-type zinc-phthalocyanine nanowire / phenothiazine according to the present invention exhibit dual traits, i.e., photothermal and photodynamic traits in single molecules, they are very useful for the development of a multifunctional molecular system and can also be usefully applied to light therapy of cancers due to their good light therapeutic effects. Also, the composite of alpha-type zinc-phthalocyanine nanowire / phenothiazine itself can exhibit fluorescence to facilitate the introduction of an imaging system, so that diagnosis and treatment can be simultaneously performed using a single substance.

Description

technical field [0001] The present invention relates to alpha (α)-form zinc-phthalocyanine nanowires (ZnPcNWs) with improved water solubility and water dispersibility, α-form zinc-phthalocyanine nanowires / phenothiazine complexes and preparation methods thereof, and A photosensitizer of the complex or a pharmaceutical composition for preventing or treating cancer. Background technique [0002] Photodynamic therapy (PDT) is widely used as a clinical cancer therapy and is an advanced method for treating malignant tumors. This photodynamic therapy specifically destroys neoplastic lesions through the generation of cytotoxic reactive oxygen species (ROS) due to the optical activity of photosensitizers. The photochemical and photophysical properties of photosensitizers are one of the decisive factors to determine the effect of photodynamic therapy. [0003] Recently, photosensitizers are classified into four main types as follows: namely, porphyrin derivatives, chlorins, porphyce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B82B1/00C07F3/06A61K49/10A61P35/00B82Y5/00
CPCA61K31/5415A61K31/555A61K41/0071A61K49/0036A61K49/0093A61K47/6929A61P35/00B82Y5/00B82Y15/00C07D487/22Y10T428/298A61K31/40B82B1/00B82B3/00A61K49/10C07F3/06A61K9/0092
Inventor 崔喜哲文惠庆李相虎
Owner POSTECH ACAD IND FOUND
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