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Method for suppressing decrease in viscosity of aqueous liquid

A technology for reducing viscosity and liquid preparation, which is applied in non-central analgesics, anti-inflammatory agents, pharmaceutical formulations, etc., can solve the problem of not being able to fully and fully cope with the problem of inhibiting the decrease of viscosity over time, not mentioning the viscosity of the composition, etc. The effect of reducing and maintaining viscosity over time

Active Publication Date: 2016-08-24
SENJU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the composition of hyaluronic acid-containing aqueous solutions is subject to various restrictions depending on the application and application method, and therefore, the need to suppress the decrease in viscosity over time cannot be fully met by relying on these conventionally known methods.
[0004] On the other hand, it is known that the pain and itchiness that occurs in affected parts such as the eyes and nasal cavity due to the use of liquid external preparations containing pranoprofen can be relieved by mixing chondroitin sulfate sodium or hyaluronic acid into such liquid external preparations. sugars can be alleviated (Patent Document 4), and for various drugs such as pranoprofen, in order to prevent foreign matter from being precipitated during long-term storage of the aqueous liquid composition containing it, a transparent Sodium hyaluronate (Patent Document 5), but these technologies do not mention the viscosity of the composition

Method used

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Embodiment

[0054] Hereinafter, although an Example is given and this invention is demonstrated more concretely, this invention is not limited to these Examples.

[0055] In addition, in each of the following examples, pranoprofen (Pharmacopoeia) manufactured by API Co., Ltd. (Eipi Iko-Pole-Sion Co., Ltd.) was used, and edetate disodium hydrate was used in Kanto Edetate sodium hydrate (pharmacopoeia) manufactured by Chemical Co., Ltd. (Kanto Chemical Co., Ltd.).

[0056] According to each formulation shown in Tables 1 to 7, an aqueous solution containing sodium hyaluronate (weight average molecular weight: 1,040,000, Seikagaku Kogyo Co., Ltd.) was prepared. The pH of each aqueous solution was adjusted to 7.5. 15 mL of each aqueous solution was poured into 15 mL-capacity containers made of polyethylene terephthalate (PET, specification RT543), sealed, and stored at 60° C. for 4 weeks. Before and after storage, according to the Japanese Pharmacopoeia (fifteenth revised edition) general te...

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Abstract

Disclosed is a novel means for suppressing decrease over time in the viscosity of an aqueous liquid agent which contains hyaluronic acid or a pharmaceutically acceptable salt thereof. The means includes a method for suppressing decrease in the viscosity of an aqueous liquid agent which contains hyaluronic acid or a pharmaceutically acceptable salt thereof, and this method is characterized by blending pranoprofen or a pharmaceutically acceptable salt thereof into the aqueous liquid agent.

Description

technical field [0001] The viscosity of polymeric polysaccharides generally decreases in aqueous solutions, and the present invention relates to the suppression of such a decrease in viscosity, and particularly relates to the suppression of the decrease in viscosity of an aqueous solution containing hyaluronic acid or a pharmaceutically acceptable salt thereof. Background technique [0002] Hyaluronic acid is a linear polymer polysaccharide composed of a large number of alternating combinations of D-N-acetylglucosamine molecules and D-glucuronic acid molecules. Aqueous solutions of hyaluronic acid or its salts are highly viscous and have moisturizing properties, etc., and thus are widely used as aqueous solutions for various purposes. However, it is well known that when an aqueous solution containing hyaluronic acid or its salt is adjusted to a pH near neutral with a buffer, the viscosity decreases during long-term storage due to decomposition of hyaluronic acid, etc., and t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/436A61K9/08A61K47/18A61K47/36A61P27/02A61P29/00
CPCA61K31/436A61K31/728A61K47/22A61P27/02A61P29/00
Inventor 根本夫规子
Owner SENJU PHARMA CO LTD
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