Preparation method and application of traditional Chinese medicine compound transdermal preparation capable of inhibiting inflammation and suppressing pains

A technology of traditional Chinese medicine and compound prescription, applied in the field of medicine, can solve the problems of use limitation, high toxicity and side effects, and achieve the effects of improving bioavailability, good curative effect, and promoting the release through the adhesive layer

Inactive Publication Date: 2014-05-14
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, high total aconitum alkaloids have high toxic and side effects, and their clinical use is limited

Method used

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  • Preparation method and application of traditional Chinese medicine compound transdermal preparation capable of inhibiting inflammation and suppressing pains

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1, Raw material preparation:

[0024] (1) Paeoniae Alba Extract

[0025] Take 10kg of Radix Paeoniae Alba, extract three times with 10 times the amount of water, 2 hours each time, filter, combine the three water extracts, recover the solvent, concentrate to about 10L, add ethanol until the alcohol content reaches about 70%, and let it stand for 12 hours , centrifuged; the supernatant recovered ethanol until it had no alcohol smell, absorbed it with 15L wet HPD-300 macroporous resin, washed it with 90L water first, then desorbed it with 75L of 30% ethanol, collected the 30% ethanol eluate, and recovered ethanol , dried under reduced pressure to obtain total glucosides of paeony. Among them, the content of paeoniflorin is 83.02%.

[0026] (2) High Aconitum Extract

[0027] Grind 10kg of Aconitum medicinal material into coarse powder, soak it in 12 times of hydrochloric acid water with pH 2.0, overnight, infiltrate on the second day, collect 15 times of per...

Embodiment 2

[0030] A traditional Chinese medicine compound transdermal gel preparation containing total glucosides of paeony and total alkaloids, the preparation method of which is as follows:

[0031] (1) Take 1 part of carbomer and add 30 parts of water to fully swell, let it stand for 12 hours, heat it in a water bath to dissolve and mix well, and obtain a transparent viscous liquid, which will be used as phase A and set aside;

[0032] (2) Take 5 parts of sodium polyacrylate (NP-700), 10 parts of micro-powdered silica gel, 0.2 parts of aluminum glycinate, 1.5 parts of total glycosides of paeony-total alkaloids of paeony, dissolve them in 30 parts of glycerin, and add the penetration enhancer azone 1 part is stirred together to dissolve and mix well, as phase B, set aside;

[0033] (3) Add a small amount of phase A to phase B several times, stir and mix well, ultrasonically degas, apply it on the medical non-woven fabric while it is hot, let it dry naturally, until the surface solidifi...

Embodiment 3

[0035] A traditional Chinese medicine compound transdermal gel preparation of total glucosides of paeony and total alkaloids, the preparation method of which is as follows:

[0036](1) Take 1 part of carbomer and add 50 parts of water to fully swell, let it stand for 12 hours, heat it in a water bath to dissolve and mix well, and obtain a transparent viscous liquid, which will be used as phase A and set aside;

[0037] (2) Take 10 parts of sodium polyacrylate (NP-700), 5 parts of micro-powdered silica gel, 0.5 parts of aluminum glycinate, 1 part of total glycosides of paeony-total alkaloids of paeony and dissolve it in 40 parts of glycerin, and add the penetration enhancer azone Stir the 2 parts together to dissolve and mix well, as phase B, set aside;

[0038] (3) Add a small amount of phase A to phase B several times, stir and mix well, ultrasonically degas, apply it on the medical non-woven fabric while it is hot, let it dry naturally, until the surface solidifies, and cut ...

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Abstract

The invention discloses a traditional Chinese medicine compound transdermal gel preparation having the effects of inhibiting inflammation and suppressing pains, and a preparation method thereof. The gel preparation is composed of a traditional Chinese medicine compound composition having the effects of inhibiting inflammation and suppressing pains, a gel matrix and a transdermal absorption penetration enhancer. The medicine composition takes aconite extract and white peony root extract as active ingredients, and has a significant synergic effect in aspects of inhibiting inflammation and suppressing pains. A curative effect is obviously superior to that of aconite total alkaloids or white peony root total glucosides being used individually. The medicine can reach lesions directly by delivering the preparation transdermally. At the same time, security can be further increased. Animal pharmacodynamic tests of the gel preparation show that pharmacological actions for inhibiting inflammation and suppressing pains of the preparation are obvious and definite, thereby providing a pain-relieving compound transdermal preparation which has better clinical curative effect and is more convenient for use.

Description

technical field [0001] The invention belongs to the technical field of medicine, relates to the field of pharmaceutical preparations and a preparation method, in particular to an anti-inflammatory and analgesic traditional Chinese medicine compound transdermal gel and a preparation method thereof. Background technique [0002] Rheumatoid arthritis, cancer pain, chronic pain and other painful diseases are diseases that seriously threaten human health. According to the statistics of the World Health Organization, there are about 400 million rheumatism patients in the world. In China, there are more than 80 million patients with rheumatoid arthritis and rheumatoid arthritis. The prevalence rate of rheumatoid arthritis in my country is 0.34%~ 0.36%, based on this calculation, there are about 4 to 5 million patients with rheumatoid arthritis. Thereby, treatment pain condition is more and more valued and paid close attention to by people. Although there are many types of pain med...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/714A61K9/06A61K47/32A61K47/22A61K47/12A61K47/10A61P29/00
Inventor 张铁军朱雪瑜田成旺王丽莉龚苏晓廖茂梁许浚孙卫
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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