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Oxiracetam composition with dehydrating and urination promoting effects and application thereof

A technology of composition and action, applied in the direction of drug combination, active ingredients of hydroxyl compounds, medical preparations containing active ingredients, etc., can solve the problems of mannitol clinical application restrictions, adverse effects on systemic functions, and increased intracranial pressure, and achieve Accelerate the recovery of cognition and limb function, convenient application, and lasting effect of lowering intracranial pressure

Inactive Publication Date: 2014-05-14
ZHUHAI HEFAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The clinical application of mannitol is greatly restricted, therefore, there is an urgent need for a dehydrating diuretic drug that can replace mannitol and avoid its side effects
[0004] In addition, in cardiovascular surgery and brain surgery, nitroglycerin and sodium nitroprusside are often used in order to reduce the tension of blood vessel walls and reduce the bleeding of cut tissues. This has become a common surgical method, which will lower the blood pressure of patients. , known as "controlled hypotension", but at the same time, it will produce side effects of increased intracranial pressure, which will adversely affect the recovery of patients after anesthesia and the recovery of systemic functions after major surgery

Method used

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  • Oxiracetam composition with dehydrating and urination promoting effects and application thereof
  • Oxiracetam composition with dehydrating and urination promoting effects and application thereof

Examples

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Effect test

Embodiment 1

[0032] An oxiracetam composition with dehydration and diuretic effect, which is prepared from raw materials with the following weights:

[0033] Oxiracetam: 200g,

[0034] Sodium chloride: 9g,

[0035] Add water for injection to 1000 mL.

[0036] The preparation method is: dissolve oxiracetam and sodium chloride with 2 / 3 water for injection, stir well, add water for injection to the full amount, add activated carbon to decolorize for 30 minutes, filter and remove carbon, measure the content of semi-finished products, and adjust the pH to 5.5 Between -6.7, finely filter to obtain a clarified liquid, potting, and steam sterilization at 100°C for 30 minutes.

Embodiment 2

[0038] An oxiracetam composition with dehydration and diuretic effect, which is prepared from raw materials with the following weights:

[0039] Oxiracetam: 160g,

[0040] Sodium chloride: 9g,

[0041] Mannitol 40g,

[0042] Add water for injection to 1000 mL.

[0043] Preparation method: Dissolve oxiracetam, sodium chloride and mannitol with 2 / 3 water for injection, stir well, add water for injection to the full amount, add activated carbon to decolorize for 30 minutes, filter and remove carbon, measure the content of semi-finished products, and adjust the pH value Between 5.5-6.7, finely filter to obtain a clarified liquid, potting, and steam sterilization at 100°C for 30 minutes.

Embodiment 3

[0045] An oxiracetam composition with dehydration and diuretic effect, which is prepared from raw materials with the following weights:

[0046] Oxiracetam: 200g,

[0047] Sodium chloride: 9g,

[0048] Furosemide 200mg,

[0049] Add water for injection to 1000 mL.

[0050] The preparation method is: dissolve oxiracetam, sodium chloride and furosemide with 2 / 3 water for injection, stir evenly, add water for injection to the full amount, add activated carbon to decolorize for 30 minutes, filter and remove carbon, measure the content of semi-finished products, adjust The pH value is between 5.5-6.7, and the clarified liquid is obtained by fine filtration, potting, and steam sterilization at 100°C for 30 minutes.

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Abstract

The invention discloses an oxiracetam composition with dehydrating and urination promoting effects and application thereof. The composition is mainly prepared from the following 1,000mL of raw materials in total: 160-200g of oxiracetam, 8.5-9.5g of sodium chloride, and the balance of water for injection. The composition can take effects of dehydrating and promoting urination quickly, has a long-lasting action of reducing intracranial pressure, is convenient to use, can pass through blood-brain barrier, but not enter brain cells, thereby avoiding increase of intracranial pressure. The composition is convenient in administration, does not crystallize at room temperature, and is suitable for sudden-onset disasters at ordinary times and cold regions, low temperature, wild field and other harsh environments in wartime. The composition can be rapidly discharged via kidneys to generate good urination promoting effect, has no renal function damage and other side effects, and has good water solubility, high solubility, no toxicity, high safety and no tolerance or accumulated side effects after repeated administration. The composition can be used for emergency and severe disease rescue, improving brain metabolism, promoting consciousness, and accelerating recovery of cognition and limb function after injuries, and has multiple-effect characteristic.

Description

Technical field [0001] The invention relates to the field of pharmaceutical compositions, in particular to an oxiracetam composition with dehydration and diuretic effects and applications thereof. Background technique [0002] Oxiracetam, chemical name: 4-hydroxy-2-oxo-1-pyrrolidine acetamide, can increase the vitality of senescent cells, significantly improve brain memory, and is effective for senile memory and mental decline. Clinically, it is suitable for brain dysfunction, memory impairment, and the progress of Alzheimer's disease. In recent years, domestic and foreign researchers have also discovered that Oxiracetam and its similar drugs have the characteristics of anti-platelet aggregation and altering the ability of red blood cells to deform. [0003] After brain trauma, cerebral hemorrhage, cerebral infarction, meningitis, brain tumor and other injuries, and after brain surgery, the patient has different degrees of increase in intracranial pressure due to brain parenchymal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/4015A61K31/635A61K31/573A61K31/515A61K31/704A61K33/26A61P7/10A61K31/21A61K31/047A61K31/355
Inventor 和光学樊伟许绍衡
Owner ZHUHAI HEFAN MEDICINE
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