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Sodium cromoglycate, naphazoline hydrochloride and chlorpheniramine maleate nasal spray

A technology of nasal spray and cromolyn, applied in the field of medicine, can solve the problems of capillary atrophy and insignificant treatment effect, and achieve the effects of promoting absorption, ensuring pH value and overcoming side effects

Active Publication Date: 2014-04-30
SHANDONG TIANSHUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the limitations of the excipients used in nasal drops, its therapeutic effect is not obvious, and it also causes serious side effects such as capillary atrophy inside the nasal cavity

Method used

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  • Sodium cromoglycate, naphazoline hydrochloride and chlorpheniramine maleate nasal spray
  • Sodium cromoglycate, naphazoline hydrochloride and chlorpheniramine maleate nasal spray

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 Naphthalene Naphthalene Nasal Spray

[0027] sodium cromolyn 50g Naphazoline Hydrochloride 0.5g Chlorpheniramine Maleate 5g Polyethylene glycol (PEG) lauryl hydroxystearate 50g Mannitol 20g purified water Add to 10000ml

[0028] Preparation process: Take the prescribed amount of sodium cromoglycate, naphazoline hydrochloride, chlorpheniramine maleate, polyethylene glycol (PEG) lauryl hydroxystearate, and mannitol in an appropriate amount of containers, add purified water , stir at room temperature, after the above materials are dissolved, add purified water to the full amount, filter through a 0.22 μm microporous membrane to obtain a chromagannaphthylamine solution, the pH value is 6.4, and pack under the condition of avoiding bacteria In qualified spray bottles, inspected and packaged.

[0029]

Embodiment 2

[0030] Embodiment 2 Naphthalene Naphthalene Nasal Spray

[0031] sodium cromolyn 150.0g Naphazoline Hydrochloride 5g Chlorpheniramine Maleate 30g Polyethylene glycol (PEG) lauryl hydroxystearate 100g Mannitol 30g purified water Add to 10000ml

[0032] Preparation process: Take the prescribed amount of sodium cromoglycate, naphazoline hydrochloride, chlorpheniramine maleate, polyethylene glycol (PEG) lauryl hydroxystearate in an appropriate amount of container, add purified water, and place at room temperature Stir at a lower temperature, after the above materials are dissolved, add mannitol and stir again, finally add purified water to the full amount, filter with a 0.22 μm microporous membrane to obtain a sarcoglycan naphthalene methylamine solution, with a pH value of 5.7, which can be used to prevent bacteria Packed in qualified spray bottles under certain conditions, inspected and packaged.

Embodiment 3

[0033] Example 3 Naphthalene Naphthalene Nasal Spray

[0034] sodium cromolyn 100.0g Naphazoline Hydrochloride 2.5g Chlorpheniramine Maleate 25.0g Polyethylene glycol (PEG) lauryl hydroxystearate 55g Mannitol 25g purified water Add to 10000ml

[0035] Preparation process: Take the prescribed amount of sodium cromoglycate, naphazoline hydrochloride, chlorpheniramine maleate, polyethylene glycol (PEG) lauryl hydroxystearate, and mannitol in an appropriate amount of containers, add purified water , stir at room temperature, after the above materials are dissolved, add purified water to the full amount, filter through a 0.22 μm microporous membrane to obtain a chromagannaphthylamine solution, the pH value is 5.6, and pack under the condition of avoiding bacteria In qualified spray bottles, inspected and packaged.

[0036]

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PUM

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Abstract

The invention provides a sodium cromoglycate, naphazoline hydrochloride and chlorpheniramine maleate nasal spray for treating allergic rhinitis. The sodium cromoglycate, naphazoline hydrochloride and chlorpheniramine maleate nasal spray comprises sodium cromoglycate, naphazoline hydrochloride, chlorpheniramine maleate, and pharmaceutically acceptable excipients, wherein the pharmaceutically acceptable excipients are selected from a buffering agent, an osmotic pressure regulator, a preservative, an absorption enhancer, a pH (Power of Hydrogen) regulator and the like. According to the sodium cromoglycate, naphazoline hydrochloride and chlorpheniramine maleate nasal spray, the active ingredients can be quickly absorbed through mucosa of nasal cavity and then acts quickly; the sodium cromoglycate, naphazoline hydrochloride and chlorpheniramine maleate nasal spray has the advantages of high bioavailability, outstanding compliance, and convenience in carrying and use, etc.

Description

technical field [0001] The invention relates to a spray, in particular to a nasal spray for treating allergic rhinitis, and belongs to the field of medicine. Background technique [0002] Rhinitis is a common and frequently-occurring disease in the current market, among which allergic rhinitis is more common. Allergic rhinitis, also known as allergic rhinitis, is a local symptom of systemic allergic reaction occurring in the nasal mucosa. factors. Because the time of exposure to allergens and the patient's body reaction are different, it is clinically divided into perennial allergic rhinitis and seasonal allergic rhinitis. The former can occur at any time; the latter occurs in allergen seasons, such as spring and autumn when there is pollen. When the disease breaks out, symptoms such as nasal congestion, runny nose, hyposmia, and slurred speech often occur. These symptoms often affect normal rest and sleep, and hinder people's health and normal work. When infants and youn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4402A61K9/12A61K47/34A61K47/10A61P11/02A61P29/00A61P37/08A61K31/352A61K31/4174
Inventor 李本超徐宜铁梁霞秦庆福董平原魏俊花马志国
Owner SHANDONG TIANSHUN PHARMA
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