Compound sulfamonomethoxine sodium injection as well as preparation method thereof
A technology of sodium methotrexate and compound sulfonamide, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of increased number of sick and disabled pigs, difficult to control, stagnation, etc. problems, to achieve the effect of expanding the antibacterial spectrum, less frequency of medication, and longer duration of action
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Embodiment 1
[0037] Prescription: sulfamethoxine sodium 1.5kg, potassium clavulanate 0.03kg, propylene glycol 3L, ethanol 1.5L, sodium thiosulfate 0.1kg, EDTA 0.001kg, water for injection to 10L.
[0038] Preparation:
[0039] 1) Mix and dissolve the prescribed amount of sulfamethoxine sodium and propylene glycol to obtain a propylene glycol solution of sulfamethoxine sodium;
[0040] 2) Mix and dissolve the prescribed amount of sodium thiosulfate and appropriate amount of water for injection to obtain sodium thiosulfate solution;
[0041] 3) Mix and dissolve the prescribed amount of potassium clavulanate with an appropriate amount of water for injection to obtain potassium clavulanate solution;
[0042] 4) Mix and dissolve the prescribed amount of EDTA and ethanol to obtain EDTA ethanol solution;
[0043] 5) Add the solutions prepared in step 2), step 3) and step 4) into the solution prepared in step 1) respectively under stirring, mix and stir well;
[0044] 6) Add 0.0...
Embodiment 2
[0048] Prescription: sulfamethoxine sodium 4kg, potassium clavulanate 0.3kg, propylene glycol 4L, ethanol 1L, sodium thiosulfate 0.1kg, EDTA 0.005kg, water for injection to 10L.
[0049] Preparation:
[0050] 1) Mix and dissolve the prescribed amount of sulfamethoxine sodium and propylene glycol to obtain a propylene glycol solution of sulfamethoxine sodium;
[0051] 2) Mix and dissolve the prescribed amount of sodium thiosulfate and appropriate amount of water for injection to obtain sodium thiosulfate solution;
[0052] 3) Mix and dissolve the prescribed amount of potassium clavulanate with an appropriate amount of water for injection to obtain potassium clavulanate solution;
[0053] 4) Mix and dissolve the prescribed amount of EDTA and ethanol to obtain EDTA ethanol solution;
[0054] 5) Add the solutions prepared in step 2), step 3) and step 4) into the solution prepared in step 1) respectively under stirring, mix and stir well;
[0055] 6) Add 0.5% (w / v) act...
Embodiment 3
[0059] Prescription: sulfamethoxine sodium 3kg, potassium clavulanate 0.1kg, propylene glycol 5L, ethanol 1.5L, sodium thiosulfate 0.2kg, EDTA 0.01kg, water for injection to 10L.
[0060] Preparation:
[0061] 1) Mix and dissolve the prescribed amount of sulfamethoxine sodium and propylene glycol to obtain a propylene glycol solution of sulfamethoxine sodium;
[0062] 2) Mix and dissolve the prescribed amount of sodium thiosulfate and appropriate amount of water for injection to obtain sodium thiosulfate solution;
[0063] 3) Mix and dissolve the prescribed amount of potassium clavulanate with an appropriate amount of water for injection to obtain potassium clavulanate solution;
[0064] 4) Mix and dissolve the prescribed amount of EDTA and ethanol to obtain EDTA ethanol solution;
[0065] 5) Add the solutions prepared in step 2), step 3) and step 4) into the solution prepared in step 1) respectively under stirring, mix and stir well;
[0066] 6) Add 0.1% (w / v) ...
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