Pefloxacin mesylate composition freeze-dried powder for injection
A technology of pefloxacin mesylate and freeze-dried powder injection, which is applied in the field of freeze-dried powder injection of pefloxacin mesylate composition for injection, and can solve the problem of increasing drug targeting, reducing toxicity, and increasing drug solubility and other problems to achieve the effect of avoiding rapid removal, eliminating active effects, and overcoming biological barriers
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Embodiment 1
[0030] Embodiment 1, preparation of pefloxacin mesylate composition freeze-dried powder for injection, in 1000 pieces.
[0031] prescription:
[0032] Pefloxacin Mesylate 200g
[0033] Chitosan Nanoparticles 140g
[0034] Water for injection 2000ml
[0035] 2. Preparation process:
[0036] The chitosan nanoparticle that takes by weighing 140g is slowly added in the water for injection of 2000ml, stirs while adding to dissolve.
[0037] Add 200 g of pefloxacin mesylate and stir to dissolve until clear.
[0038] Adjust the pH to 5.1 with the buffer salt of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and filter the liquid through 0.45 μm and 0.22 μm microporous membranes to detect the content of intermediates , according to pefloxacin mesylate 0.2g per bottle to calculate the loading.
[0039] Fill according to the test requirements, put it into a freeze dryer after half-tam...
Embodiment 2
[0040] Embodiment 2, preparation of pefloxacin mesylate composition freeze-dried powder for injection, in 1000 pieces.
[0041] 1. Prescription:
[0042] Pefloxacin Mesylate 200g
[0043] Chitosan Nanoparticles 128g
[0044] Water for injection 2000ml
[0045] 2. Preparation process:
[0046] The chitosan nanoparticle that takes by weighing 128g is slowly added in the water for injection of 2000ml, stirs while adding to dissolve.
[0047] Add 200 g of pefloxacin mesylate and stir to dissolve until clear.
[0048] Adjust the pH to 5.1 with the buffer salt of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and filter the liquid through 0.45 μm and 0.22 μm microporous membranes to detect the content of intermediates , according to pefloxacin mesylate 0.2g per bottle to calculate the loading.
[0049] Fill according to the test requirements, put it into a freeze dryer after half-...
Embodiment 3
[0050] Example 3. Preparation of lyophilized powder injection of pefloxacin mesylate composition for injection, in 1000 vials.
[0051] prescription:
[0052] Pefloxacin Mesylate 200g
[0053] Chitosan Nanoparticles 152g
[0054] Water for injection 2000ml
[0055] 2. Preparation process:
[0056] The chitosan nanoparticle that takes by weighing 152g is slowly added in the water for injection of 2000ml, stirs while adding to dissolve.
[0057] Add 200 g of pefloxacin mesylate and stir to dissolve until clear.
[0058] Adjust the pH to 5.1 with the buffer salt of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and filter the liquid through 0.45 μm and 0.22 μm microporous membranes to detect the content of intermediates , according to pefloxacin mesylate 0.2g per bottle to calculate the loading.
[0059] Fill according to the test requirements, put it into a freeze dryer after ...
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