Shu'an sanitary expandable vaginal suppository, and preparation method and detection method thereof

The technology of a vaginal expansion suppository and a detection method is applied in the field of Shu'an Hygiene vaginal expansion suppository and its preparation, and can solve the problems of undisclosed dosage of pharmaceutical ingredients, disordered expansion, unreliable quality control method, etc. Outflow prevention effect

Active Publication Date: 2014-12-10
哈尔滨田美药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But this patent does not disclose the report that can solve the above-mentioned side effect problem, although it has the effect of treating vaginitis and spermicide at the same time, the effect is still unsatisfactory
In addition, "Chinese Journal of Family Planning" published an article titled "Experimental Research on the In Vitro and External Spermicidal and Anti-fertility Effects of Bosidei Hygienic Suppository" in the 5th issue of 1997, the total number 31, which disclosed a Bosidi sanitary suppository, which is refined from Chinese herbal medicines such as licorice, grass, pinellia, and cnidium, has the effect of treating vaginitis and killing sperm. Although the effect is good, the dosage of each drug ingredient is not disclosed
In addition, the Shuan Sanitary Suppository also has the following technical problems: 1. The traditional Shuan Sanitary Suppository has no expansion effect, or the expansion is disordered, which greatly reduces the clinical application; , the content, stability, and melting time between batches vary greatly

Method used

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  • Shu'an sanitary expandable vaginal suppository, and preparation method and detection method thereof
  • Shu'an sanitary expandable vaginal suppository, and preparation method and detection method thereof
  • Shu'an sanitary expandable vaginal suppository, and preparation method and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] Prescription quantity: 1000 pieces of matrix and the weight of the traditional Chinese medicine composition do not match the claims

[0107] Composition Dosage:

[0108] Liao Diaozhu 300g LMZ 100g Cnidium 100g

[0109] Rhubarb 200g Wild Chrysanthemum 200g Licorice 150g

[0110] Honeysuckle 100g Bitter dish 100g

[0111] Substrate dosage:

[0112] Lecithin 10g, coconut oil 150g, palm kernel oil 150g;

[0113] Massa Estarinum A300g

[0114] Cotton sliver consumption: 1000 pieces, each 2g

[0115] Chinese medicine composition preparation method:

[0116] a) Take 50% of Liao Diao bamboo, LMZ and Fructus Cnidii, add 6 times the amount of 50% ethanol, extract for 2 hours, a total of 1 time, combine the extracts, recover ethanol, and obtain the first ethanol extract;

[0117] b) Take the other 50% of Liao Diao bamboo, rhubarb, licorice, and Kudiezi, add 6 times the amount of water, extract for 4 hours, extract twice, combine the extracts to obtain the water extract, and...

Embodiment 2

[0123] Prescription quantity: 100 pieces

[0124] Composition Dosage:

[0125] Liao Diaozhu 35g Double-faced Acupuncture 15g Cnidium 30g

[0126] Rhubarb 30g Wild Chrysanthemum 30g Licorice 20g

[0127] Honeysuckle 30g Bitter dish 30g.

[0128] Substrate dosage:

[0129] Lecithin 5g, coconut oil 70g, palm kernel oil 70g;

[0130] Massa Estarinum AS12g;

[0131] 100 slivers, 1g each

[0132] Chinese medicine composition preparation method:

[0133] a) Take 50% of Liao Diaozhu, LMianzhen and Cnidium Fructus, add 8 times the amount of 75% ethanol, extract for 4 hours, a total of 3 times, combine the extracts of each time, recover ethanol, and obtain the first ethanol extract;

[0134] b) Take the other 50% of Liao Diao bamboo, rhubarb, licorice, and Kudiezi, add 7 times the amount of water, extract for 5 hours, extract 3 times, combine the extracts to obtain the water extract, and keep the medicinal residue;

[0135] c) Take wild chrysanthemum, honeysuckle and medicinal r...

Embodiment 3

[0140] Prescription quantity: 100 pieces

[0141] Composition Dosage:

[0142] Liao Diaozhu 25g Double-faced Acupuncture 20g Cnidium 15g

[0143] Rhubarb 15g Wild Chrysanthemum 15g Licorice 10g

[0144] Substrate dosage:

[0145] Lecithin 3g, coconut oil 40g, palm kernel oil 40g;

[0146] Massa Estarinum T11g;

[0147] 100 slivers, 3g each

[0148] Chinese medicine composition preparation method:

[0149] a) Take 50% of Liao Diaozhu, Liangmianzhen and Cnidium, add 7 times the amount of 65% ethanol, extract for 3 hours, a total of 2 times, combine the extracts, recover ethanol, and obtain the first ethanol extract;

[0150] b) Take the other 50% of Liao Diao bamboo, rhubarb, licorice, and Kudiezi, add 8 times the amount of water, extract for 6 hours, extract 3 times, combine the extracts to obtain the water extract, and keep the medicinal residue;

[0151] Combine the extracts to obtain the water extract, and keep the medicinal residues;

[0152]c) Take wild chrysanthem...

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Abstract

The invention relates to a Shu'an sanitary expandable vaginal suppository. The expandable suppository comprises 30-500 weight parts of a traditional Chinese medicine composition, 800-2000 weight parts of a matrix and 500-4000 weight parts of an expansion carrier. The suppository is fully expanded, and the drug-containing layer and the inner wall of the vagina can fully contact to prevent outflow liquid. The expandable vaginal suppository has beneficial effects of high efficacy and low incidence on pruritus vulvae, pain and frequent micturition; and the Shu'an sanitary expandable vaginal suppository employs six originally created leading technologies. Surprisingly, the suppository provided by the invention can the treat various vaginitis and at the same time has strong spermicidal effect.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, in particular to a Shu'an hygienic vaginal expansion suppository and a preparation method and detection method thereof. Background technique [0002] Volume 61 of the "New Drug Standards" discloses a Shu'an sanitary suppository with a grain weight of 1.5g. It is a yellow-brown conical suppository mainly made of Liao Diaozhu, Liangmianzhen, Cnidium, rhubarb, wild chrysanthemum, and licorice. The sanitary tampon is used for fungal vaginitis, bacterial vaginosis and damp-heat syndrome. The prominent problem of this drug is that it has poor curative effect on symptoms such as genital itching, pain, and frequent urination of users. More importantly, it will induce the above symptoms in patients without such symptoms before, and the incidence rate is relatively high. Although those skilled in the field of general pharmacy would think that the drug formulation will contain irritating ingredients, t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/758A61K9/02A61K47/44A61P15/02A61P15/00A61P15/18A61P31/10A61P31/04G01G17/00G01N33/15
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司
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