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High-sensitivity non-enzymatic glucose electrochemical sensor and production method thereof

An electrochemical and glucose technology, applied in the direction of electrochemical variables of materials, can solve the problems of high detection limit and low sensitivity of electrochemical sensors, and achieve the effects of simple process, simple operation and high sensitivity

Active Publication Date: 2013-12-04
铜陵汇泽科技信息咨询有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is: in the prior art, the electrochemical sensor also has the problems of low sensitivity and too high detection limit

Method used

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  • High-sensitivity non-enzymatic glucose electrochemical sensor and production method thereof
  • High-sensitivity non-enzymatic glucose electrochemical sensor and production method thereof
  • High-sensitivity non-enzymatic glucose electrochemical sensor and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation of NiONPs-CNFs

[0029] A. Weigh 0.01g of solid carbon nanofibers (30-100nm in diameter and 2-10μm in length) and add to the solution containing 0.127g NiCl 2 ·6H 2 O solution, ultrasonically stirred until uniform;

[0030] B. While stirring, use 5% (solute mass fraction) ammonia water to adjust the pH of the above solution to 11, and then stir for 3 hours;

[0031] C. Filtrate, wash, dry, and incubate at 300° C. for 2 hours to obtain NiONPs-CNFs.

[0032] figure 1 It is the XRD pattern of NiONPs and NiONPs-CNFs prepared in this example. It can be seen from the figure that a strong diffraction peak appears at 25°, which is the (002) plane of CNFs with hexagonal crystal structure. According to the standard spectrum of NiONPs and the literature "Synthesis of CuONiO core-shell nanoparticles by homogeneous precipitation method", it shows that NiONPs-CNFs composites were successfully synthesized.

Embodiment 2

[0034] Preparation of High Sensitivity Glucose Sensor

[0035] A glassy carbon electrode with a diameter of 3 mm was used as the base electrode, and Al at 0.3 μm and 0.5 μm 2 o 3 After the polishing powder is polished to a mirror surface, it is ultrasonically washed with 1:1 nitric acid, ethanol and deionized water for 3 minutes.

[0036] The NiONPs-CNFs prepared in Example 1 were dispersed in DMF solvent with a concentration of 4 mg mL -1 , sonicate for 30 minutes, take 2 μL with a micro-sampler, drop-coat it on the surface of the above-mentioned glassy carbon electrode that has been treated, dry it at room temperature, put the electrode into 0.2M NaOH solution, and use cyclic voltammetry At a scan rate of 100 mV / s, it was activated for 15 cycles, thereby preparing the glucose electrochemical sensor.

Embodiment 3

[0038] Detection experiment

[0039] The detection experiment was carried out on a CHI411A electrochemical workstation and a three-electrode system. The reference electrode was a saturated calomel electrode, the counter electrode was a platinum wire electrode, and the working electrode was the electrochemical sensor prepared in Example 2 of the present invention. The solution is the bottom liquid, and at 0.45V, the time-current curves obtained by adding different concentrations of glucose are as follows: figure 2 as shown,

[0040] The linear range of this glucose electrochemical sensor can be derived (as image 3 shown) is 0.5μM~6.5mM, the sensitivity is as high as 2891.7μA mM -1 cm -2 , the linear correlation is very good, R=0.997, and the detection limit is as low as 0.2μM.

[0041] So far, the technology similar to the present invention, such as: A highly sensitive nonenzymatic glucose sensor based on NiO-modified multi-walled carbon nanotubes, the linear range is 2μM...

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Abstract

The invention relates to a method of detecting glucose by a nickel oxide nanoparticles and carbon nanofibers composite (NiONPs-CNFs) modified electrode, namely modification of supported nickel oxide nanoparticle carbon nanofiber layer on the surface of a conventional electrode. The method includes: subjecting carbon nanofibers of supported nickel oxide nanoparticles to even ultrasonic dispersion in solvent, dispensing the dispersion liquid to the surface of the conventional clean electrode, airing at the room temperature, performing cyclic voltammetry activation in NaOH solution to obtain the high-sensitivity non-enzymatic glucose electrochemical sensor. The production method of nano composites is simple, fast and low in cost; the produced electrochemical sensor is high in sensitivity, fine in stability, wide in linear range, and fine in repeatability. The sensor is expectedly widely applied to the fields of diagnosis of diabetes mellitus, clinical medicine, food technologies and detection and the like.

Description

technical field [0001] The invention belongs to the field of electrochemical sensors, in particular to a highly sensitive enzyme-free glucose electrochemical sensor and a preparation method thereof. Background technique [0002] With the rapid development of society and the improvement of people's living standards, the prevalence of diabetes has also increased. In November 2012, the Diabetes Society of the Chinese Medical Association (CDS) and the International Diabetes Federation (IDF) jointly released the results of a study on the socioeconomic impact of diabetes in China. times. Real-time and reliable detection of blood glucose concentration is an effective method for diagnosing and controlling diabetes. [0003] At present, the methods for detecting glucose at home and abroad mainly include high performance liquid chromatography and spectrophotometry. Although these methods have high accuracy, the instruments used are expensive, the operation is complicated, and profes...

Claims

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Application Information

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IPC IPC(8): G01N27/30
Inventor 张静朱小莉陈智栋马剑磊
Owner 铜陵汇泽科技信息咨询有限公司
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