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Pharmaceutical composition of cefotiam hydrochloride for injection and compound amino acid injection

A technology of cefotiam hydrochloride and compound amino acid, applied in the pharmaceutical composition field of cefotiam hydrochloride for injection and compound amino acid injection

Inactive Publication Date: 2014-09-10
HAINAN LINGKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In order to overcome a series of problems existing in the prior art, the inventor creatively finds the combination of adopting compound amino acid solution, cefotiam hydrochloride and anhydrous sodium carbonate, is about to be independently packaged by cefotiam hydrochloride and anhydrous sodium carbonate cefotiam hydrochloride powder for injection and 18 kinds of crystalline amino acids and xylitol sterilized injection solution are dissolved and mixed into the body, which not only improves the anti-inflammatory effect, but also reduces the cephalosporin hydrochloride Deficiency of adverse reactions of tiam, with unexpected technical effects

Method used

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  • Pharmaceutical composition of cefotiam hydrochloride for injection and compound amino acid injection
  • Pharmaceutical composition of cefotiam hydrochloride for injection and compound amino acid injection
  • Pharmaceutical composition of cefotiam hydrochloride for injection and compound amino acid injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Preparation of Cefotiam Hydrochloride Powder Injection for Injection

[0033] prescription:

[0034]

[0035] making process:

[0036] (1) 250g of cefotiam hydrochloride sterile powder (in C 18 h 23 N 9 o 4 S 3 (meter) and 60g of anhydrous sodium carbonate sterile powder are mixed evenly and sent to the subpackaging room (the ambient temperature of the subpackaging post is 18℃~26℃, and the relative humidity is below 65%). Debug the subpackaging machine and adjust the number of steps to adjust the loading volume , so that the filling volume reaches the specified range, and then it is divided into low-borosilicate glass control injection bottles, and the stopper is fully pressed and capped.

[0037] (2) cefotiam hydrochloride sterile powder 500g (in C 18 h 23 N 9 o 4 S 3 (meter) and 120g of anhydrous sodium carbonate sterile powder are mixed evenly and sent to the subpackaging room (the ambient temperature of the subpackaging post is 18℃~26℃, and t...

Embodiment 2

[0040] Example 2 Preparation of Compound Amino Acid Injection

[0041] prescription:

[0042]

[0043] making process:

[0044] (1) Take 60L of water for injection and boil it, add 5000g of xylitol to dissolve it, then add 150g of activated carbon and boil for 20 minutes, filter back to decolorize for 20 minutes, then filter into dilute irrigation.

[0045] (2) After filtering the xylitol liquid into the dilution tank, nitrogen gas is introduced immediately, and at the same time, another 40 L of water for injection that has been pretreated with 150 g of activated carbon for 20 minutes of boiling and adsorption is combined with the xylitol liquid, and the cooling water is used When the combined solution was cooled to 60°C, feeding began.

[0046] (3) Divide 50g of the antioxidant sodium bisulfite into two equal parts, put 25g of one part of the antioxidant into the combined liquid, then add 289g of arginine hydrochloride and 246g of histidine hydrochloride according to t...

Embodiment 3

[0049] Example 3 Preparation of Combination Packaged Drugs

[0050] Combination 1: Cefotiam Hydrochloride Powder Injection for Injection 0.25g and Compound Amino Acid Injection 100ml.

[0051] Combination 2: Cefotiam hydrochloride powder for injection 0.25g and compound amino acid injection 250ml.

[0052] Combination 3: Cefotiam Hydrochloride Powder Injection for Injection 0.25g and Compound Amino Acid Injection 500ml.

[0053] Combination 4: Cefotiam Hydrochloride Powder for Injection 0.5g and Compound Amino Acid Injection 100ml.

[0054] Combination 5: Cefotiam Hydrochloride Powder for Injection 0.5g and Compound Amino Acid Injection 250ml.

[0055] Combination 6: Cefotiam Hydrochloride Powder for Injection 0.5g and Compound Amino Acid Injection 500ml.

[0056] Combination 7: Cefotiam Hydrochloride Powder for Injection 1.0g and Compound Amino Acid Injection 100ml.

[0057] Combination 8: Cefotiam Hydrochloride Powder for Injection 1.0g and Compound Amino Acid Injectio...

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Abstract

The invention relates to a pharmaceutical composition of cefotiam hydrochloride for injection and compound amino acid injection, and especially relates to an application product of the pharmaceutical composition, wherein the application product comprises cefotiam hydrochloride for injection and compound amino acid injection. Administration method comprises following steps, 0.25 to 2g of cefotiam hydrochloride for injection is dissolved in appropriate amount of compound amino acid injection, and the mixture is applied to 30min to 2h of intravenous drop infusion, wherein 0.25 to 2g of cefotiam hydrochloride is the dosage of one time. Compared with a method of compatible mixing application of cefotiam hydrochloride for injection and compound amino acid injection, the pharmaceutical composition is capable of simplifying steps, improving safety, and increasing clinical application quality and bioavailability of medicines, and possesses significant benefits on the stability of cefotiam hydrochloride.

Description

technical field [0001] The invention relates to a pharmaceutical composition of cefotiam hydrochloride for injection and compound amino acid injection, in particular to a combination of cefotiam hydrochloride for injection and a sterilized injection prepared from 18 kinds of crystalline amino acids and xylitol The application packaging belongs to the technical field of medicine. Background technique [0002] Cefotiam hydrochloride is a second-generation cephalosporin antibiotic, and its effect on Gram-positive bacteria is similar to that of Cefazolin, while it is effective against Gram-negative bacteria, such as Haemophilus, Escherichia coli, Klebsiella, and Streptococcus mirabilis. Proteus, etc. have better effects, and also have antibacterial effects on Enterobacter, Citrobacter, and indole-positive Proteus. Its mechanism of action is to bind to the penicillin-binding protein on the bacterial cell membrane, acylate the transpeptidase, inhibit the synthesis of the bacteria...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/546A61K47/10A61P31/04A61P29/00A61K31/195A61K31/198A61K31/401A61K31/405A61K31/4172
Inventor 陶灵刚
Owner HAINAN LINGKANG PHARMA CO LTD
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