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Novel marine organism washing-free disinfection solution and its application

A technology of marine organisms and disinfectant, which is applied in the directions of drug combinations, plant raw materials, medical preparations containing active ingredients, etc., and can solve the problems of difficulty in adapting to long-term surgery, poor long-term killing effect, and weak activity of filamentous fungi. , to achieve the effect of reducing the probability of clinical infection, broad-spectrum and efficient pathogenic flora, and excellent bactericidal effect

Active Publication Date: 2014-12-17
RIZHAO ZHONGSHENG MARINE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Triclosan has a certain antibacterial spectrum, but it is biased towards antibacterial
Triclosan has some activity against mycobacteria and candida, but less activity against filamentous fungi
It can be used to clean and disinfect the skin of hands, but the disinfection gel has poor long-term killing effect during use
[0011] Chinese patent application CN1498538A discloses a marine biological disinfectant with chitin, alginic acid, agarose gelatin, Yujie pure DP300, and cedarwood alcohol as active ingredients. The defect of poor long-term antivirus effect makes it difficult to adapt to the needs of long-term surgery

Method used

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  • Novel marine organism washing-free disinfection solution and its application
  • Novel marine organism washing-free disinfection solution and its application
  • Novel marine organism washing-free disinfection solution and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1: novel marine life disposable disinfectant of the present invention

[0039] A new type of disposable disinfectant for marine organisms, the active ingredients include chitosan, chitosan oligosaccharide, prebiotics, baicalin, polyhexamethylene guanidine, lysozyme, and Polygonum cuspidatum extract. Among them, the concentration of chitosan is 1%, the concentration of chitooligosaccharide is 3%, the concentration of prebiotics is 1.2%, the concentration of baicalin is 3.7%, the concentration of polyhexamethyleneguanidine is 1%, the concentration of lysozyme is 2.5%, Knotweed Extract 3%.

[0040] Taking the preparation of one kilogram of gel as an example, each kilogram of gel contains 10g chitosan, 30g chitosan oligosaccharide, 12g prebiotics, 37g baicalin, 10g polyhexamethyleneguanidine, 25g lysozyme, and 30g Polygonum cuspidatum extract . The specific preparation method is to add 10g of chitosan, 25g of lysozyme and 30g of chitosan oligosaccharide in...

Embodiment 2- Embodiment 6

[0041] Embodiment 2-Example 6 The present invention's novel marine organisms disposable disinfectant

[0042] The skin disinfectant prescription is shown in Table 1, and the preparation method is the same as the preparation method of the marine organism disposable disinfectant in Example 1.

[0043] The percentage composition of table 1 embodiment 2-embodiment 6 skin antiseptic solution

[0044]

Embodiment 7

[0045] Embodiment 7 In vitro bacteriostasis experiment of the disinfection composition of the present invention

[0046] The strains and media used in this experiment were A-hemolytic Streptococcus (32209), B-hemolytic Streptococcus (32210), Escherichia coli (44102), Proteus vulgaris (49101), Pseudomonas aeruginosa Pseudomonas aeruginosa , Candida albicans , Salmonella paratyphi A (50001), Shigella dysenteriae (51252), Staphylococcus aureus [26111(5)], Influenza bacillus (58529-4 ), nutrient agar medium (China Institute for the Control of Drugs and Biological Products); turbidimetric tube (China Bacterial Turbidity Standard, China Institute for the Control of Pharmaceutical Biological Products).

[0047]Antibacterial test in vitro: ① Preparation of drug-containing agar plates. Dilute the test substance in proportion to prepare medium with different drug concentrations, heat to adjust the required pH value, sterilize at 121°C for 30 min, and cool to 45°C. Pour into a steril...

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Abstract

Belonging to the technical field of disinfection, the invention discloses a novel marine organism washing-free disinfection solution. In view of the disadvantages of existing disinfection technologies, especially preoperative disinfection technologies, the invention provides the novel marine organism washing-free disinfection solution, which comprises the following active ingredients by mass: 0.5%-2% of chitosan, 1-4% of chitosan oligosaccharide, 2%-8% of baicalin, 0.5%-2% of prebiotics, 0.5%-1.5% of polyhexamethylene guanidine, 2%-5% of lysozyme and 1.5%-5% of a Polygonum cuspidatum extract. The disinfection effect is good. The disinfection solution disclosed by the invention can be used for sanitation disinfection or the hand disinfection or skin disinfection in preoperative disinfection. With excellent sterilization effect and lasting effect, the novel marine organism washing-free disinfection solution has very good application prospects and economic benefits.

Description

technical field [0001] The invention belongs to the technical field of disinfectants, and in particular relates to a novel disposable disinfectant for marine organisms. Background technique [0002] In clinical medical care work, medical staff must strictly abide by aseptic operation when performing various operations. Especially in surgery, patients are frequently contacted, and the chance of infection is relatively high. Therefore, skin disinfection is required in various clinical treatments and diagnostic processes; disinfection is an important part of infection control, and the success of disinfection directly affects the quality of treatment. Although some disinfectants among various skin disinfectants can meet the requirements in antivirus effect, they have short action time, narrow bactericidal spectrum, and strong skin irritation, so they are not suitable for widespread use in clinical surgery. The selection of high-efficiency and low-toxic skin disinfectants becom...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/704A61K38/47A61K31/785A61P31/04A61P17/00
Inventor 张坤焦念强刘中伟杜广青
Owner RIZHAO ZHONGSHENG MARINE BIOTECH
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