Quality control method of traditional Chinese medicine tablet for treating nasosinusitis

Abstract

The invention relates to a quality control method of a traditional Chinese medicine tablet for treating nasosinusitis. According to the method, a thin-layer chromatography is utilized to perform quality standard identification on platycarya strobilacea infructescence, prunella vulgaris, wild chrysanthemum flower, astragalus membranaceus, violet magnolia, Chinese parsnip root and liquorice; and a high efficiency liquid chromatography is utilized to measure the content of astragaloside serving as an index ingredient of the astragalus membranaceus. By the method, the quality of the traditional Chinese medicine tablet for treating the nasosinusitis is controlled well, so that the safety of medicine administration is ensured.

Description

technical field [0001] The invention relates to a method for detecting the main effective components of traditional Chinese medicine tablets for treating sinusitis. Background technique [0002] Sinusitis (biyuan) is a common disease with a high incidence, which brings many unbearable pains to patients and seriously affects their daily work and life. [0003] The effective components of the traditional Chinese medicine tablet for treating sinusitis involved in the present invention include Fructus fragrans, Prunella vulgaris, wild chrysanthemum, Astragalus, Xinyi, Fangfeng, Angelica Radix, Licorice, and Chuanxiong. The functions of clearing away heat and detoxification, promoting blood circulation and removing blood stasis, are the monarch medicine in the prescription; Prunella vulgaris clears heat and detoxifies, dispels phlegm and disperses knots, wild chrysanthemum clears heat and detoxifies, purifies fire and reduces swelling, and astragalus strengthens the body and remo...

AI Technical Summary

Problems solved by technology

The sugar-coated tablet has been clinically used for more than 20 years since it was approved by the national health administrative department in 1988, and the national drug standard WS is now implemented. 3 -15(X-06)-98(Z), in the published standards, only the physical and chemical identification of active ingredients of alkaloids and flavonoids, TLC identification of licorice, and TLC scanning content determination of astragaloside IV are specified method, there is no thin-layer chromatographic identification of active ingredients such as the main ingredients of the prescription, Prunella vulgaris, and wild chrysanthemum

[0004] On February 4, 2004, the Chinese Patent Gazette disclosed a patent application titled "a Chinese patent medicine for treating sinusitis" with a publication number of 1471929. Its formula is the same as that of the Chinese medicine tablet formula for treating sinusitis involved in the present invention; On February 7, 2009, the Chinese Patent Gazette published a patent application titled "a pharmaceutical composition for treating rhinorrhea and its preparation method" and the publication number is 1907335. The composition described in this invention is obtained by removing the seeds. 630 parts of Huaxiangshu infructome, 630 parts of Prunella vulgaris, 251 parts of wild chrysanthemum, 420 parts of astragalus, 251 parts of Xinyue, 251 parts of Fangfeng, 251 parts of Angelica dahurica, 251 parts of licorice, and 251 parts of Chuanxiong are prepared from raw materials, including Dosage forms such as pills, granules, tablets, capsules, dripping pills, and oral liquid preparations; although this patent has been improved on the basis of the original formula, in the preparation method, the parameters in the preparation method of the tablet are too few and unclear , the quality of the finished product cannot be guaranteed. At the same time, since the preparation is added with talcum powder and coated with sugar, it is not suitable for diabetics to take

[0006] "Astragalus" is one of the main ingredients, its active ingredient is astragaloside IV, the national standard WS 3 -15(X-06)-98(Z) specifies that the detection method of astragaloside IV is thin-layer scanning method, but in production practice, this method is complicated to operate and has poor reproducibility, so refer to "Chinese Pharmacopoeia" In the 2005 edition of the content determination method under the item "Astragalus", the original detection method was modified to high performance liquid chromatography to determine the content of astragaloside IV in this preparation, and the detection method was improved to enhance the controllability of the quality of the preparation

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