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Preparation method of carbon quantum dots with high fluorescence property

A carbon quantum dot and fluorescence technology, which is applied in the fields of nanomaterials and medical engineering, can solve the problems of restricting the large-scale production and practical application of fluorescent carbon quantum dots, complicated subsequent processing methods, uneconomical and environmental protection, etc., and achieves low steric hindrance, High fluorescence performance, simple equipment effect

Inactive Publication Date: 2013-10-09
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, these methods often require large-scale equipment, relatively expensive raw materials and complicated subsequent processing methods, etc. These methods are not only uneconomical and environmentally friendly, but also limit the large-scale production and production of fluorescent carbon quantum dots due to their high cost. practical application

Method used

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  • Preparation method of carbon quantum dots with high fluorescence property
  • Preparation method of carbon quantum dots with high fluorescence property
  • Preparation method of carbon quantum dots with high fluorescence property

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Example 1: Put 0.1g of glycine and 0.9g of glucose powder into a 100mL beaker, then pour 20ml of deionized water into the beaker, and stir magnetically at room temperature (15-25°C) until the glycine and glucose powder are fully dissolved , to obtain a uniform and transparent solution; the above solution was added to a 50ml polytetrafluoroethylene liner, put into a stainless steel reaction kettle, and heated in an electric oven at a constant temperature of 180°C for 3h to obtain a light yellow solution containing carbon quantum dots. After the solution is naturally cooled, filter with a medium-speed filter paper to remove insoluble black precipitates, centrifuge at 15,000g to remove large particles, collect the supernatant and inject it into a dialysis bag with a molecular cutoff of 1,000Da for dialysis, the dialysis time is 72h, and change it every 12h water. The dialyzed product was rotovaped to obtain a concentrated solution. The concentrated solution is freeze-drie...

Embodiment 2

[0030] Example 2: Put 0.2g of glycine and 0.8g of glucose powder into a 100mL beaker, then pour 20ml of deionized water into the beaker, and stir magnetically at room temperature (15-25°C) until the glycine and glucose powder are fully dissolved , to obtain a uniform and transparent solution; the above solution was added to a 50ml polytetrafluoroethylene liner, put into a stainless steel reaction kettle, and heated in an electric oven at a constant temperature of 180°C for 3h to obtain a light yellow solution containing carbon quantum dots. After the solution is naturally cooled, filter with a medium-speed filter paper to remove insoluble black precipitates, centrifuge at 15,000g to remove large particles, collect the supernatant and inject it into a dialysis bag with a molecular cutoff of 1,000Da for dialysis, the dialysis time is 72h, and change it every 12h water. The dialyzed product was rotovaped to obtain a concentrated solution. The concentrated solution is freeze-drie...

Embodiment 3

[0031] Example 3: Put 0.5g of glycine and 0.5g of glucose powder into a 100mL beaker, then pour 20ml of deionized water into the beaker, and stir magnetically at room temperature (15-25°C) until the glycine and glucose powder are fully dissolved , to obtain a uniform and transparent solution; the above solution was added to a 50ml polytetrafluoroethylene liner, put into a stainless steel reaction kettle, and heated in an electric oven at a constant temperature of 180°C for 3h to obtain a light yellow solution containing carbon quantum dots. After the solution is naturally cooled, filter with a medium-speed filter paper to remove insoluble black precipitates, centrifuge at 15,000g to remove large particles, collect the supernatant and inject it into a dialysis bag with a molecular cutoff of 1,000Da for dialysis, the dialysis time is 72h, and change it every 12h water. The dialyzed product was rotovaped to obtain a concentrated solution. The concentrated solution is freeze-drie...

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Abstract

The invention discloses a preparation method of carbon quantum dots with a high fluorescence property by using glycine and glucose as precursors. The method comprises using the glycine as a surface passivating agent, the glucose as a carbon source material and a hydro-thermal reaction vessel as a reaction platform, carrying out a high-temperature and high-pressure hydrothermal reaction, and removing residues and water through dialysis and freeze drying to obtain carbon quantum dot powder. The preparation method of the carbon quantum dots has characteristics of simple operation, low cost and easy mass production. The prepared carbon quantum dots have excellent properties of high fluorescence property, photobleaching resistance, adjustable light emission and good biocompatibility, can be successfully applied in live cell fluorescence imaging and flow cytometry analysis, and is broad in application prospect in biomedical fields.

Description

technical field [0001] The invention relates to a carbon quantum dot with high fluorescent performance prepared by a one-step method and its application in biomedical imaging, and belongs to the field of nanometer materials and medical engineering. Background technique [0002] Due to their excellent physical and chemical properties, fluorescent nanomaterials are widely used in chemical catalysis, environmental monitoring, optoelectronic devices, and biosensors. Among them, quantum dots (quantum dots), as a new type of nanomaterial superior to traditional fluorescent dyes, has attracted the attention of biomedical researchers. Early quantum dots prepared from heavy metals have been used as fluorescent probes in living cell labeling and in vivo cell tracking, and achieved good results. However, the application of such heavy metal quantum dots in the biomedical field is greatly limited due to their own cytotoxicity and environmental hazards. Recently, a major breakthrough ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B31/02B82Y30/00C01B32/15
Inventor 杜凤移张苗苗邵启祥夏圣许化溪许文荣钱晖刘霞
Owner JIANGSU UNIV
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