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Technology for improving drug effects of Mythic Fungus and Chinese angelica through utilizing Mythic Fungus-Chinese angelica bidirectional fermentation

A two-way fermentation, angelica technology, applied in the field of bioengineering, can solve the problems of artificial cultivation of Ganoderma lucidum, long growth cycle, scarcity of wild Ganoderma lucidum, etc., to achieve the effect of enhancing immunity, good application prospects, and delaying aging.

Inactive Publication Date: 2013-09-25
GANSU AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, the demand for Ganoderma lucidum has been increasing, and wild Ganoderma lucidum is very rare, which is far from meeting people's needs. Artificially cultivated Ganoderma lucidum has a long growth cycle.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Liquid two-way fermentation—weigh some dried Angelica sinensis, cut into 0.5cm*2cm square strips with a slicer, then add 9 times the mass of aqueous solution, stir and soak for 3 hours; then centrifuge at 2000r / min for 15min , take the supernatant; use Ganodorma lucidum as the fermented medicinal fungus seeds, produce two ganoderma strains by sterile inoculation, inoculate in the middle of the slant medium (PDA medium), and place at 28°C for constant temperature cultivation 7 days in the box. Use corn flour liquid medium to expand culture; by adding 30% concentration of angelica water extract to the set basal medium, make a complete medium (corncob: wheat bran = 1: 3, MgSO 4 (0.05%), (NH 4 ) 2 SO 4 (0.2%), KH 2 PO 4 (0.1%) are mass concentrations). Insert Ganoderma lucidum seed liquid, place at 28°C, shaker speed 150r, and natural Ph conditions, and cultivate for 7 days; when Ganoderma lucidum grows over the entire fermentation tank, and the mycelium balls are sph...

Embodiment 2

[0020] Liquid two-way fermentation—weigh some dry Angelica sinensis, grind it into a 40-mesh powder through a pulverizer, and then add an aqueous solution at a ratio of 1:9 (that is, add 10g of astragalus powder to 90mL of pure water), and stir And soak for 1 hour; then centrifuge at 1000r-3000r / min for 15min, take the supernatant; use Ganodorma lucidum as the fermented medicinal fungus seed, use sterile inoculation to produce two ganoderma strains, and inoculate them on the slant medium (PDA medium) in the middle, placed in a constant temperature incubator at 28°C for 7 days. Adopt corn flour liquid medium to expand cultivation; by adding 30% (accounting for the whole weight of medium) concentration of Astragalus water extract in the set basal medium, make whole culture medium (corn cob: wheat bran=1 : 3, MgSO 4 (0.05%), (NH 4 ) 2 SO 4 (0.2%), KH 2 PO 4 (0.1%) are mass concentrations). Insert Ganoderma lucidum seed liquid, place at 28°C, shaker speed 150r, and natural ...

Embodiment 3

[0022] Solid-state two-way fermentation—weigh some dried Angelica sinensis, grind them into 40-mesh powder through a pulverizer; use Ganodorma lucidum as the fermented medicinal fungus seeds, activate PDA slant medium, and use corn flour for liquid culture basal expansion culture; by adding 3% (accounting for the whole weight of the medium) concentration of Astragalus powder in the set basal medium to make a complete medium (corncob: wheat bran = 1: 3, MgSO 4 (0.05%), (NH 4 ) 2 SO 4 (0.2%), KH 2 PO 4 (0.1%) are mass concentrations). Insert Ganoderma lucidum seed solution, place it at 28°C, control oxygen flow through mechanical ventilation, and cultivate for 7 days under natural Ph conditions; when Ganoderma lucidum grows all over the fermenter, and the mycelium ball is spherical, the appearance is dense and white , the fermentation is over.

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PUM

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Abstract

The invention discloses a technology for improving the drug effects of Mythic Fungus and Chinese angelica through utilizing Mythic Fungus-Chinese angelica bidirectional fermentation. The technology comprises the steps of Chinese angelica pretreatment, Mythic Fungus strain activation, culturing medium preparation, bidirectional fermentation, and fermentation extraction and use. The purpose of the invention is enhancing the biological activities and drug effects of Mythic Fungus and Chinese angelica, and the oxidation resistance activity of Chinese angelica is improved 60-100 times after fermentation. Mythic Fungus and Chinese angelica can be used as functional foods and medicines for strengthening the body resistance and prolonging the life, and have good application prospects.

Description

technical field [0001] The invention belongs to the technical field of bioengineering and relates to a microbial bidirectional fermentation technology using traditional Chinese medicine as a raw material. Background technique [0002] Gansu has abundant medicinal resources, but at present, the supply market is generally dominated by raw medicinal materials and primary processed products. The content of active ingredients is low, and the value-added benefits are few, and the market's demand for high-end and diversity cannot be guaranteed. The top priority is to carry out scientific and technological research on authentic medicinal materials and improve the utilization value of traditional Chinese medicinal materials. The output of Angelica, Codonopsis, Astragalus, Rhubarb and Licorice accounted for 95%, 60%, 50%, 60% and 25% of the national total respectively, and the export volume of the above five medicinal materials accounted for more than 80% of the national total. Angel...

Claims

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Application Information

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IPC IPC(8): A61K36/232A61K36/481A23L1/29A61P39/06A61P37/04A23L33/00
Inventor 艾对元魏龙贠建民张卫兵张紊玮
Owner GANSU AGRI UNIV
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